Computational Biology Scientist

Job Description:
We are seeking a talented Computational Biologist / Bioinformatics Scientist to tackle challenging bioinformatics and computational biology problems and work collaboratively with research groups to build the tools, algorithms, and pipelines required to support the development of new, transformative CRISPR/Cas9-based gene editing therapies.

Responsibilities:

• Develop and implement computational biology tools and programs to support all gene editing and research activities
• Generate and test hypotheses on genome-scale data using analytical and statistical methods
• Balance integration and extension of existing bioinformatics and next generation sequencing (NGS) tools with the creation of new tools and algorithms as needed for varying project and problem contexts
• Communicate scientifically rigorous findings via oral and written communications, visualizations, and presentations

Minimum Qualifications:

• Degree (Ph.D., or M.S., B.S. with 6+ years of relevant experience) in quantitative or basic science (computational biology, bioinformatics, computer science, chemistry, physics, mathematics, or applied science preferred)
• Experience in developing computational pipelines to analyze DNA and RNA high-throughput sequencing data and usage of common bioinformatics tools (e.g. bwa, BEDtools, GATK, IGV)
• A solid grasp of Python and/or R is essential for success; familiarity with other languages such as Java, C++, Perl, and MATLAB is also helpful
• Ability to work independently and successfully in a matrix environment, prioritize and manage multiple tasks simultaneously, integrate cross-functional issues and balance competing priorities effectively

Preferred Qualifications:

• Advanced degree (Ph.D. or equivalent)
• The ideal candidate will have experience working in close collaboration with cell / molecular biologists and would contribute to the experimental and process by designing and building algorithms to answer therapeutic questions, and ultimately guiding the therapeutic products in the right direction
• Familiarity with molecular research techniques (qPCR, ddPCR, NGS library prep) and gene editing (CRISPR/Cas9)
• Proficiency with statistical methods and/or machine learning
• Ability to understand and make decisions and recommendations about high level strategy as well as about the details of an analysis project or experiment
• A high degree of energy, accuracy and attention to detail, and a passion for creating transformative gene-based medicines to patients with serious diseases
• Proficiency with handling large-scale genomic data in a Linux and/or cloud environment (e.g. AWS)
• Experience working in fast paced team environments (industry and start-up experience is a plus)

Competencies:

• Entrepreneurial Spirit/Flexibility – An adventurous spirit, exhibiting A readiness in undertaking a task or project with considerable initiative and risk. The ability to adapt to working effectively within a variety of situations; adapts enthusiastically to organizational change and to changes in job demands.
• Perseverance – Pursues tasks with energy, drive and initiative, even in the face of adversity.
• Results Oriented – Drives issues to closure and gets the job done.
• Communication and Teamwork – The ability to effectively express ideas in written and oral context. The ability to work co-operatively with others; the genuine desire to be a part of a team and contribute to organizational and team goals.

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Requeriments :

• Technical Bachelor

Skills :

• Bioinformatics
• Computational Biology
• DNA sequencing
• Lunix/Unix
• Machine Learning
• Next Generation Sequencing
• Programing in C++
• Programing in Python
• Programming in Java
• Programming in Matlab
• Programming in PERL
• Programming in R
• RNA-seq
• Statistics

Areas :

• Computational Biology

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Additional Info:
If interested and qualified, please include Requisition # 2017-243 in the subject line when emailing resume to: careers@crisprtx.com .

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