Job ID: 40-25643
Job date: 2017-04-25
End Date:
Company : University of Pennsylvania Country : Role : Other
Job date: 2017-04-25
End Date:
Company : University of Pennsylvania Country : Role : Other
Job Description:
The Director of Bioinformatics (DB) oversee and handle all aspects of bioinformatics research at the Gene Therapy Program(GTP) at PENN. GTP is a complex R&D organization consisting of research laboratories supported by multiple core functions which provide internal capacity to perform gene transfer studies from basic research through phase 1 proof-of-concept human trials. We currently employ 150FTEs with an annual operating budget $50M. The R&D enterprise has at its core a translational infrastructure that includes: technology discovery, specialized immunology assays operating under Good Laboratory Practices (GLP), a Vector Core and Manufacturing unit that conducts Good Manufacturing Practices (GMP)-based assays and oversees CMOs in vector production, and a large non-clinical program for animal testing under GLP, including nonhuman primate and mouse vivaria; GTP collaborates with the Department of Medicine in the organization and conduct of phase 1 trials. In addition to these translational programs, GTP is involved in an ambitious vector discovery program called AAV 3.0 which is being leveraged against standard gene replacement therapy programs, as well as research in genome editing. These programs involve multiple federal, nonprofit and commercial partners. Virtually all aspects of the R&D efforts involve modern day tools of molecular and cellular biology which require extensive computational analysis of the data. We are in need of extensive support in terms of bioinformatics. The DB will be asked to build a bioinformatics program to support GTP’s R&D efforts as well as being responsible for hands-on analysis work. He/she will have available the necessary equipment to build out the program, however he/she may need to build a larger team as the computational tools become more accessible to the scientists. A successful candidate for the DB role should have hands on experience with Next Generation Sequencing analysis as well as have knowledge of genome editing and virus genomes. Qualifications: -The minimum of a Master’s degree and 5 years to 7 years of experience or equivalent combination of education and experience required. * Extensive knowledge of life science research in both academic and bio-pharmaceutical settings * Proven track record of accomplishment in bioinformatics especially as it relates to evaluation of deep sequencing RNA and DNA data -Ability to work with computer scientists in the development of novel computational tools for life science research -Self starter but also a strong desire to contribute and work collaboratively to achieve goals -Success in roles requiring execution of multiple tasks while responding to multiple priorities -Highly functioning, detail-oriented, and analytical candidate who can think strategically -Excellent oral/written communication skills required
Additional Info:
The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning. Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play. The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more. Affirmative Action Statement : Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class. Special Requirements Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.[Click Here to Access the Original Job Post]
The Director of Bioinformatics (DB) oversee and handle all aspects of bioinformatics research at the Gene Therapy Program(GTP) at PENN. GTP is a complex R&D organization consisting of research laboratories supported by multiple core functions which provide internal capacity to perform gene transfer studies from basic research through phase 1 proof-of-concept human trials. We currently employ 150FTEs with an annual operating budget $50M. The R&D enterprise has at its core a translational infrastructure that includes: technology discovery, specialized immunology assays operating under Good Laboratory Practices (GLP), a Vector Core and Manufacturing unit that conducts Good Manufacturing Practices (GMP)-based assays and oversees CMOs in vector production, and a large non-clinical program for animal testing under GLP, including nonhuman primate and mouse vivaria; GTP collaborates with the Department of Medicine in the organization and conduct of phase 1 trials. In addition to these translational programs, GTP is involved in an ambitious vector discovery program called AAV 3.0 which is being leveraged against standard gene replacement therapy programs, as well as research in genome editing. These programs involve multiple federal, nonprofit and commercial partners. Virtually all aspects of the R&D efforts involve modern day tools of molecular and cellular biology which require extensive computational analysis of the data. We are in need of extensive support in terms of bioinformatics. The DB will be asked to build a bioinformatics program to support GTP’s R&D efforts as well as being responsible for hands-on analysis work. He/she will have available the necessary equipment to build out the program, however he/she may need to build a larger team as the computational tools become more accessible to the scientists. A successful candidate for the DB role should have hands on experience with Next Generation Sequencing analysis as well as have knowledge of genome editing and virus genomes. Qualifications: -The minimum of a Master’s degree and 5 years to 7 years of experience or equivalent combination of education and experience required. * Extensive knowledge of life science research in both academic and bio-pharmaceutical settings * Proven track record of accomplishment in bioinformatics especially as it relates to evaluation of deep sequencing RNA and DNA data -Ability to work with computer scientists in the development of novel computational tools for life science research -Self starter but also a strong desire to contribute and work collaboratively to achieve goals -Success in roles requiring execution of multiple tasks while responding to multiple priorities -Highly functioning, detail-oriented, and analytical candidate who can think strategically -Excellent oral/written communication skills required
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Additional Info:
The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning. Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play. The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more. Affirmative Action Statement : Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class. Special Requirements Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.[Click Here to Access the Original Job Post]