Job Requirements: Doctorate Degree
Bioinformatician / Population Geneticist Job Summary A bioinformatician/ population geneticist is required to undertake genomics research on perennial fruit species and their pathogens and pests. Much of the research undertaken will work towards investigating the molecular mechanisms involved in host resistance to pathogens. The successful applicant will work across multiple BBSRC funded projects to elucidate the genetic basis of disease resistance in the first instance to the oomycete pathogens Phytophthora cactorum and Phytophthora fragariae in the octopoloid strawberry Fragaria x ananassa. An interest in the evolutionary dynamics of host-pathogen interactions would be highly desirable. Key areas of the job Population-level analysis of candidate resistance gene and pathogen effector genes: Familiarity with basic population genetics approaches to detect selection from nucleotide sequences either using between species data (e.g. PAML) and/or within species (e.g. McDonald- Kreitman tests, Tajima’s D, haplotype tests etc) Analysis of RNA-seq transcriptome time-course data in order to identify candidate host and effector genes which are implicated in host-pathogen interactions. Analysis of gene regulatory networks is an important component of this work, linking expression to genes with QTL and analysing subgenome-specific patterns of expression variation Quantitative genetics analysis of disease resistance using mixed modelling approaches- a working knowledge of mixed-model approaches to the analysis of quantitative trait data and genotypic data to identify genetic variants contributing to variation in complex traits Developing national and international collaborations with other organisations involved in genomics and bioinformatics research on horticultural crops Publishing results in high impact refereed journals and giving presentations at national and international conferences Working in accordance with EMR’s Health and Safety Objectives, comply with EMQA (East Malling Quality Assurance) requirements and contribute to EMR’s corporate responsibilities [More]
Competitive: St. Jude Children's Research Hospital: The bioinformatics research scientist will work on integrative analysis of whole-genome, whole exome and transcriptoming sequencing data with epigenetic data including WGBS, ChIP-seq and RNA-seq to understand the role of epigenetic regulation in childhoo Memphis, Tennessee [More]
International Institute of Molecular and Cell Biology: Two PhD student positions in RNA bioinformatics are available in the Bujnicki group in IIMCB, Warsaw, Poland. We are looking for junior scientists with energy and passion, interested in bioinformatics, software development and biological data analysis, Poland [More]
We are seeking energetic and passionate argonauts of all stages (postdocs, graduate students, undergraduates, and research associates) to join our team. We are passionate about understanding the fundamental challenge of cancer evolution. If you are naturally curious about biology, want to invent new technologies, and enjoy working in a creative and dynamic environment, we would love to work with you! [More]
Your role will be to lead the effective running of the Advanced Sequencing STP for the Francis Crick Institute. You will manage a state of the art facility with cutting edge technology and technology development. Reporting to the Director of Crick Science Operations, you will manage a team of up to 10 facility staff. The post holder will work closely with scientific group leaders and the Bioinformatics and Genomics STPs to provide a highly effective sequencing service to over 100 laboratories within the Francis Crick Institute. [More]
At Memorial Sloan Kettering (MSK), we’re not only changing the way we treat cancer, but also the way the world thinks about it. By working together and pushing forward with innovation and discovery, we’re driving excellence and improving outcomes. For the 26th year, MSK has been named a top hospital for cancer by U.S. News & World Report. We’re treating cancer, one patient at a time. Join us and make a difference every day. [More]
We are seeking a Postdoctoral Scientist in Inflammation to join Professor Alison Simmons’ research group. The goal of this project is to characterise pathogenic lesions in Crohn’s disease at a global molecular level to highlight biological pathways that are over or underactive within human intestinal subsets in Crohn’s. The Postdoctoral Fellowship is being funded and performed in close collaboration with Celgene, and will involve short secondments within Celgene labs to for the postholder to develop skills linked to work in industry. In Oxford the Postdoctoral Scientist will work in collaboration with members of the Target Discovery Institute and Wellcome Trust Centre for Human Genetics, Oxford. [More]
We are seeking two Postdoctoral Scientists to join Professor Chris Newbold’s Molecular Parasitology research group to work on the understanding of immunity and pathogenesis in malaria. The role will involve work on the control of expression of these multi-gene families, their function and the immune response to them using extensive sequence data that has been compiled. [More]
A postdoc position funded by an ERC Consolidator grant is available in theVan Attikum laboratory at the Leiden University Medical Center (LUMC; Leiden, the Netherlands). As a postdoc you will study how chromatin remodeling enzymes counteract DNA strand breaks and replication stress in order to prevent genomic instability in human cells. The research will encompass a cross-disciplinary approach that combines novel and cutting-edge genomics with bioinformatics, genetics, biochemistry and high-resolution microscopy. [More]
The Senior Bioinformatics Engineers an exceptional candidate who has both deep bioinformatics experience and extensive software architecture experience. We operate at the crossroads of cancer genomics, software, and data science and are looking for that rare individual who has experience and passion for all three. Our platforms are focused on mining of cancer genomic data sets, understanding resistance to targeted therapy, matching genomic profiles to clinical trials, and identifying exceptional responders to targeted therapy. Technical and scientific challenges for the platform include data mining and visualization of large-scale cancer genomic data sets, extracting information from natural language text and building web-based data analytics platforms. [More]