Job ID: 2007446
Job date: 2017-11-20
End Date:
Company : Carnegie Mellon University Country : Role : Research Scientist
Job date: 2017-11-20
End Date:
Company : Carnegie Mellon University Country : Role : Research Scientist
Job Description:
The Molecular Biosensor and Imaging Center (MBIC) in MCS is searching for a Research Associate III. The incumbent will work on NIH funded research to develop broadly applicable high-throughput yeast co-display technology to isolate and improve small recombinant immunoproteins (nanobodies) that specifically recognize proteins important in biology and medicine. The project is based on a unique confluence of MBIC’s own fluorogen activating proteins and cognate dyes, yeast molecular biology, CRISPR/Cas9-based recombinant engineering, next generation sequencing, and fluorescence activated cell sorting. This position requires an aptitude for recombinant biology benchwork and bioinformatic analysis. For someone interested in a career related to academic or industrial biotechnology, this is an excellent opportunity to broaden one’s skills and perspective in an interdisciplinary and scientifically stimulating work environment. You will work as a team with a senior yeast molecular biologist, Dr. Chris Szent-Gyorgyi. For description of research, see: http://bruchez-lab.mbic.cmu.edu/research/hts-of-nanobody-affinity-reagents/. Collaborative core responsibilities will include:
Additional Info:
The Mellon College of Science (MCS) is comprised of four core Academic Departments (Biological Sciences, Chemistry, Physics and Mathematical Sciences) and 12 Research Centers and Institutes, and MCS faculty also collaborate in many other programs and research centers at Carnegie Mellon. These organizations support a highly innovative interdisciplinary environment for scientific and technological advancement. MCS faculty members are nationally and internationally recognized for their research in a variety of fields, including dye chemistry, polymer science, neuroscience, cellular trafficking, and yeast biology. Please visit “Why Carnegie Mellon” to learn more about becoming part of an institution inspiring innovations that change the world. http://www.cmu.edu/jobs/why-cmu/index.html. A listing of employee benefits is available at: http://www.cmu.edu/jobs/benefits-at-a-glance/index.html. Carnegie Mellon University considers applicants for employment without regard to, and does not discriminate on the basis of, gender, race, protected veteran status, disability, or any other legally protected status. [Click Here to Access the Original Job Post]
The Molecular Biosensor and Imaging Center (MBIC) in MCS is searching for a Research Associate III. The incumbent will work on NIH funded research to develop broadly applicable high-throughput yeast co-display technology to isolate and improve small recombinant immunoproteins (nanobodies) that specifically recognize proteins important in biology and medicine. The project is based on a unique confluence of MBIC’s own fluorogen activating proteins and cognate dyes, yeast molecular biology, CRISPR/Cas9-based recombinant engineering, next generation sequencing, and fluorescence activated cell sorting. This position requires an aptitude for recombinant biology benchwork and bioinformatic analysis. For someone interested in a career related to academic or industrial biotechnology, this is an excellent opportunity to broaden one’s skills and perspective in an interdisciplinary and scientifically stimulating work environment. You will work as a team with a senior yeast molecular biologist, Dr. Chris Szent-Gyorgyi. For description of research, see: http://bruchez-lab.mbic.cmu.edu/research/hts-of-nanobody-affinity-reagents/. Collaborative core responsibilities will include:
- Implement yeast display library construction and screening.
- Work with chemists to evaluate fluorogenic dye reagents.
- Analyze and evaluate next generation sequencing data and carry out bioinformatics-based analysis of mammalian and bacterial target proteins.
- Document and archive recombinant constructs and strains.
- M.S. or B.S. in Biology, Biochemistry, Molecular Biology, Microbiology, Genetics, Biotechnology, Genomics, or Computational Biology, or equivalent experience.
- Experience with molecular biological methods, including DNA isolation, PCR, plasmid-based cloning, and in vitro mutagenesis.
- Experience with one or more next generation sequencing technologies such as Illumina sequencing library construction, Ig-seq, RNA-seq, ATAC-seq, CAGE-seq, or alternatively, computational expertise in genomic bioinformatics.
- Experience with molecular immunology or yeast genetics is a plus, but is not required.
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Additional Info:
The Mellon College of Science (MCS) is comprised of four core Academic Departments (Biological Sciences, Chemistry, Physics and Mathematical Sciences) and 12 Research Centers and Institutes, and MCS faculty also collaborate in many other programs and research centers at Carnegie Mellon. These organizations support a highly innovative interdisciplinary environment for scientific and technological advancement. MCS faculty members are nationally and internationally recognized for their research in a variety of fields, including dye chemistry, polymer science, neuroscience, cellular trafficking, and yeast biology. Please visit “Why Carnegie Mellon” to learn more about becoming part of an institution inspiring innovations that change the world. http://www.cmu.edu/jobs/why-cmu/index.html. A listing of employee benefits is available at: http://www.cmu.edu/jobs/benefits-at-a-glance/index.html. Carnegie Mellon University considers applicants for employment without regard to, and does not discriminate on the basis of, gender, race, protected veteran status, disability, or any other legally protected status. [Click Here to Access the Original Job Post]