Job ID: 1721
Job date: 2017-09-11
End Date:
Company : AnaptysBio Inc Country : Role : Research Scientist
Job date: 2017-09-11
End Date:
Company : AnaptysBio Inc Country : Role : Research Scientist
Job Description:
This position works in a matrix environment with molecular biologists, cell biologists, protein scientists and external collaborators to use pharmacogenomics, gene expression profiling, and next generation sequencing datasets to identifynew drug targets for inflammation and immuno-oncology projects as well as disease-associated biomarkers for existing projects. Performs computational biology and bioinformatics analysis. Essential Functions: • Apply computational analysis and biological interpretation to public genomic, transcriptomic, and proteomic datasets and in-house studies to support target validation and prioritization, clinical development, and data-driven decision making across therapeutic programs • Apply computational tools to identify and study novel therapeutic targets and assist in elucidating the mechanisms of action of ongoing and new projects • Apply comprehensive literature surveys and meta-analysis of published studies on biological targets and pathways to support target identification • Present therapeutic antibody concepts, rationales, target validation plans, target product profiles, and project plans to research leadership teams • Identify biomarkers to support molecular and genetic-based patient selection criteria in the early clinical development phase • Participate in the planning and execution of collaborative projects with CROs and academic research groups • Contribute major sections of internal and external reports and patent applications. • May lead projects, including effectively leading cross-functional teams in the implementation of the company platform technologies, determining project strategy and key experiments, analyzing and interpreting data, and preparing associated documentation.
Additional Info:
[Click Here to Access the Original Job Post]
This position works in a matrix environment with molecular biologists, cell biologists, protein scientists and external collaborators to use pharmacogenomics, gene expression profiling, and next generation sequencing datasets to identifynew drug targets for inflammation and immuno-oncology projects as well as disease-associated biomarkers for existing projects. Performs computational biology and bioinformatics analysis. Essential Functions: • Apply computational analysis and biological interpretation to public genomic, transcriptomic, and proteomic datasets and in-house studies to support target validation and prioritization, clinical development, and data-driven decision making across therapeutic programs • Apply computational tools to identify and study novel therapeutic targets and assist in elucidating the mechanisms of action of ongoing and new projects • Apply comprehensive literature surveys and meta-analysis of published studies on biological targets and pathways to support target identification • Present therapeutic antibody concepts, rationales, target validation plans, target product profiles, and project plans to research leadership teams • Identify biomarkers to support molecular and genetic-based patient selection criteria in the early clinical development phase • Participate in the planning and execution of collaborative projects with CROs and academic research groups • Contribute major sections of internal and external reports and patent applications. • May lead projects, including effectively leading cross-functional teams in the implementation of the company platform technologies, determining project strategy and key experiments, analyzing and interpreting data, and preparing associated documentation.
Requirements
Qualifications
Education & Experience: • Ph.D. in computational biology, biochemistry, molecular biology or related discipline, and 5+ years of post-doctoral or industry experience. • Experience and knowledge in genomic, proteomic, and transcriptomic data analyses, NGS sequence analysis, biostatistics, and bioinformatics. • Strong background in genetic association analysis and gene expression profiling from large multivariate datasets. • Extensive experience in designing new drug concepts and developing project plans for early drug concept validation • Experience with deep sequencing of antibody repertoires a plus Additional Responsibilities: • Writes and reviews manuscripts, grants, and intellectual property documents • Designs antigens, recombined antibodies, secondary reagents and antibody libraries • Performs additional bioinformatics and computational biology to include: o Data mining and statistics of somatic hypermutation data and public antibody repertoire data o Protein modeling, graphics and design • Manages projects with the goal of rapid identification of superior therapeutic candidates, to include: o Coordinates activities for representatives of Molecular Biology, Cellular Biology, and Protein Sciences o Runs project teams meetings o Writes project reports and leads exhaustive program reviews o Performs and communicates background research within the therapeutic/project area: o Intellectual propery, Target Biology, competitive landscape, bioassays and animal models, and design goals o Presents data, conclusions and potential strategies to senior management • Provide performance reviews, feedback and career development for subordinates Personal Competencies: • Ability to communicate clearly, and to report and present experimental results and analysis to colleagues and management. • Effective interpersonal skills, including both written and oral communication skills. • Ability to work effectively in as a team player in a complex, changing environment. • Highly self-motivated and results-oriented, with the capacity to organize assignments, and work within deadlines. • Able to successfully work both independently and as a team member in a dynamic, fast-paced environment, committed to success and getting the job done. • Ability to function in a fast-paced entrepreneurial environment. • Ability to work independently while also willing to follow protocols. • Strong analytical and organizational skills. • Highly attentive to details. Other Information: • Position may require occasional evening and/or weekend commitment • Position may require working with biological and/or chemical hazards • Position might require lifting up to 20 poundsRequeriments :
Skills :
- Bioinformatics
- Biomarker Discovery
- Biostatistics
- Computational Biology
- Data Mining
- Genetics
- genomic
- Modeling
- Next Generation Sequencing
- Statistics
- Transcriptomics
Areas :
Additional Info:
[Click Here to Access the Original Job Post]