Director of Computational Sciences

Utilize expertise in protein structure/function, computational methodologies and structure-based drug design to advise project teams and the scientific leadership of the company; influence project selection and strategy ultimately resulting in the discovery of small molecule clinical candidates   Roles/Deliverables

• Functions as an influential project team member; guides the direction of compound design strategies in projects
• Serves as an expert in the evaluation of protein constructs, crystal structures and other structural biology data
• Investigates the protein dynamics of systems through the integration of computational and experimental techniques
• Evaluates homology of various proteins; may develop homology or pharmacophore models for use by project teams
• Conducts high-level calculations for project teams
• Contributes to the conception, evaluation and initiation of new projects
• May develop ADMET predictive tools for use by scientists from multiple disciplines
• Maintains a current understanding of computational science literature and methodology, as well as the scientific literature related to specific drug discovery projects
• Demonstrates inter-disciplinary knowledge of drug discovery (e.g., chemistry, enzymology, cellular pharmacology, pharmacokinetics) and is able to use this knowledge to influence project strategy
• Develops and contributes to company’s intellectual property domain by way of patents and/or publications
• Prepares and organizes data for presentations; presents written and oral reports; may communicate research efforts to collaborators and corporate partners or at scientific meetings
• May lead a group or project