Job ID:
Job date: 2014-10-02
End Date:
Company : Wellcome Trust Sanger Institute Country : Role : Postdoc
Job date: 2014-10-02
End Date:
Company : Wellcome Trust Sanger Institute Country : Role : Postdoc
Job Description:
Postdoctoral Fellow (Rare disease genetic analysis) Deciphering the genetic causes of rare, prenatal anomalies Salary range: £29829 to £37393 per annum plus excellent benefits. This position is fixed-term for 3 years. We are seeking to recruit a creative, highly-motivated and productive Postdoctoral Fellow to work on an exciting new three year project called Prenatal Assessment of Genomes and Exomes (PAGE), which is a collaboration between the Sanger Institute and the UK National Health Service (NHS). The project aim is to understand the genetic causes of severe, unexplained, structural anomalies identified by prenatal ultrasound. We are using the latest DNA sequencing technologies to identify genetic variation that might explain the structural anomalies and so provide useful information for families and increase our knowledge of gene function in health and disease. The PAGE project builds upon the success of the Deciphering Developmental Disorders (DDD) project (www.ddduk.org), which is a similar collaboration between the Sanger Institute and the NHS that is identifying genetic causes in families with severe, undiagnosed, developmental disorders that are apparent in children from birth, or shortly after. This new postdoctoral position will join Matt Hurles's group at the Sanger Institute, which includes experimental human, mouse and zebrafish geneticists as well as bioinformaticians and statistical geneticists. Our current focus is on harnessing new genomic technologies, such as exome and genome sequencing, to identify novel disease-causing variants and model these variants in cellular and animal models. Our rare disease research focuses on developmental disorders, either identified prenatally (by ultrasound), or postnatally (through pediatric cardiology and clinical genetics). The successful applicant will drive the genetic analyses of large-scale sequencing datasets to discover new causes of developmental disorders. Applicants should have a background in Medical Genetics or Statistical Genetics or Computational Genomics, with either a proven track record in large-scale data analyses or who have demonstrated exceptional potential during a recently completed PhD. Strong data analytical skills are essential. Our work is highly collaborative and integrative and the postholder will be required to interact with a multi-disciplinary group of clinicians, laboratory scientists (including mouse and zebrafish geneticists) and computational biologists. There is a strong commitment to personal and professional development with the group, and the successful applicant will be encouraged to develop their own ideas and build-up a strong academic profile. Essential Skills PhD in medical genetics, statistical genetics or a related computation genomics discipline Demonstrably strong data analytical skills Ability to work collaboratively Effective communication skills within the team and with collaborators Efficient time management Experience of preparing manuscripts for publication Knowledge of statistical analysis of large genetic datasets Ideal Skills Experience of analysis of rare genetic diseases Experience with quality control of large genetic datasets Experience of analysing NGS data Extensive experience in computer programming Ability to develop novel statistical analyses Experience of population genetics analyses Experience of genetic association testing Experience of functional modelling of disease genes/variants Other information Now is an extremely exciting time for the study of human genetic variation. The Wellcome Trust Sanger Institute (WTSI) is a world leader in large-scale human genetics, model organism genetics, and computational genomics. We are consolidating and expanding an ambitious programme of research using the latest experimental technologies to characterise genetic variation and unravel the molecular basis of rare diseases and complex traits. This programme combines large-scale experimental data generation, on a variety of platforms, with sophisticated data analyses to identify causal variants underlying rare diseases and complex traits. The Sanger Institute is located near Cambridge, UK on the stunning Wellcome Trust Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), the Centre for Therapeutic Target Validation, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. It is an excellent environment in which to work and collaborate with researchers on campus and around the world and benefit from cross-fertilisation of ideas. To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre. Our Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and 25 days Annual Leave plus Bank Holidays. We also have a gym, two cafes, a nursery, dining facilities, and a free campus Bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus. Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. Informal enquiries can be directed to meh@sanger.ac.uk Please provide a CV and cover letter. Closing date: 28th October 2014
Additional Info:
Postdoctoral Fellow (Rare disease genetic analysis) Deciphering the genetic causes of rare, prenatal anomalies Salary range: £29829 to £37393 per annum plus excellent benefits. This position is fixed-term for 3 years. We are seeking to recruit a creative, highly-motivated and productive Postdoctoral Fellow to work on an exciting new three year project called Prenatal Assessment of Genomes and Exomes (PAGE), which is a collaboration between the Sanger Institute and the UK National Health Service (NHS). The project aim is to understand the genetic causes of severe, unexplained, structural anomalies identified by prenatal ultrasound. We are using the latest DNA sequencing technologies to identify genetic variation that might explain the structural anomalies and so provide useful information for families and increase our knowledge of gene function in health and disease. The PAGE project builds upon the success of the Deciphering Developmental Disorders (DDD) project (www.ddduk.org), which is a similar collaboration between the Sanger Institute and the NHS that is identifying genetic causes in families with severe, undiagnosed, developmental disorders that are apparent in children from birth, or shortly after. This new postdoctoral position will join Matt Hurles's group at the Sanger Institute, which includes experimental human, mouse and zebrafish geneticists as well as bioinformaticians and statistical geneticists. Our current focus is on harnessing new genomic technologies, such as exome and genome sequencing, to identify novel disease-causing variants and model these variants in cellular and animal models. Our rare disease research focuses on developmental disorders, either identified prenatally (by ultrasound), or postnatally (through pediatric cardiology and clinical genetics). The successful applicant will drive the genetic analyses of large-scale sequencing datasets to discover new causes of developmental disorders. Applicants should have a background in Medical Genetics or Statistical Genetics or Computational Genomics, with either a proven track record in large-scale data analyses or who have demonstrated exceptional potential during a recently completed PhD. Strong data analytical skills are essential. Our work is highly collaborative and integrative and the postholder will be required to interact with a multi-disciplinary group of clinicians, laboratory scientists (including mouse and zebrafish geneticists) and computational biologists. There is a strong commitment to personal and professional development with the group, and the successful applicant will be encouraged to develop their own ideas and build-up a strong academic profile. Essential Skills PhD in medical genetics, statistical genetics or a related computation genomics discipline Demonstrably strong data analytical skills Ability to work collaboratively Effective communication skills within the team and with collaborators Efficient time management Experience of preparing manuscripts for publication Knowledge of statistical analysis of large genetic datasets Ideal Skills Experience of analysis of rare genetic diseases Experience with quality control of large genetic datasets Experience of analysing NGS data Extensive experience in computer programming Ability to develop novel statistical analyses Experience of population genetics analyses Experience of genetic association testing Experience of functional modelling of disease genes/variants Other information Now is an extremely exciting time for the study of human genetic variation. The Wellcome Trust Sanger Institute (WTSI) is a world leader in large-scale human genetics, model organism genetics, and computational genomics. We are consolidating and expanding an ambitious programme of research using the latest experimental technologies to characterise genetic variation and unravel the molecular basis of rare diseases and complex traits. This programme combines large-scale experimental data generation, on a variety of platforms, with sophisticated data analyses to identify causal variants underlying rare diseases and complex traits. The Sanger Institute is located near Cambridge, UK on the stunning Wellcome Trust Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), the Centre for Therapeutic Target Validation, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. It is an excellent environment in which to work and collaborate with researchers on campus and around the world and benefit from cross-fertilisation of ideas. To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre. Our Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and 25 days Annual Leave plus Bank Holidays. We also have a gym, two cafes, a nursery, dining facilities, and a free campus Bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus. Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. Informal enquiries can be directed to meh@sanger.ac.uk Please provide a CV and cover letter. Closing date: 28th October 2014
Requeriments :
Skills :
Areas :
Additional Info: