Job ID: 221435
Job date: 2018-01-08
End Date:
Company : The Jackson Laboratory Country : Role : Research Scientist
Job date: 2018-01-08
End Date:
Company : The Jackson Laboratory Country : Role : Research Scientist
Job Description:
The Ke Lab invites one Associate Research Scientist to join at The Jackson Laboratory in Bar Harbor, Maine. The Ke Lab focuses on RNA, a central node of genetic information flow from DNA to protein (https://www.jax.org/research-and-faculty/faculty/shengdong-ke ). Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanism of RNA, the Ke lab utilizes multidisciplinary approaches, including cutting-edge computational biology, biochemistry, innovative bio-technologies, genetics and molecular biology. We are especially interested in m6A RNA biology: 1) the fundamental mechanism of m6A RNA biology, and 2) the biological effects of m6A regulation in nerve system, using mouse and human iPS models. (References: 1] Ke, S. et al. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover, Genes & Development 2017, 31: 990-1006; 2] Ke, S. et al. A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation, Genes & Development 2015, 29:2037-53.) Qualified candidates would be self-motivated and career oriented individuals, have a genuine interest in addressing complex biological questions and a PhD or MD with background in one or multiple areas, including computational biology, biochemistry, molecular biology, biotechnology, neurosciences, immunology, stem cell, or cancer biology. Skills of quantitative programming or biochemistry are particularly preferred but not required. Key Responsibilities:
Additional Info:
A cover letter outlining general interests, and career goals should be submitted with CV/Resume as one document to consider application complete. About us: The Jackson Laboratory, (JAX, www.jax.org) is a nonprofit biomedical research institute with over 1,800 employees whose mission is to discover precise genomic solutions for human disease and empower the global biomedical community in the shared quest to improve human health. JAX’s research facility in Bar Harbor, Maine is a National Cancer Institute-designated Cancer Center and a world-renowned expert in mammalian genetics. JAX also has facilities in Sacramento, California, and The Jackson Laboratory for Genomic Medicine in Farmington, Connecticut. JAX employees work in a collaborative, value-driven and team-based environment where the focus is on advancing science and improving patients’ lives. Researchers apply genetics to increase the understanding of human disease and advance treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. The Jackson Laboratory's 43-acre scenic campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums and galleries. Our Values: INTEGRITY - Courage and commitment to do what is right PEOPLE - Inspiring our people to enhance the health of all ONE TEAM - Unified by our promise to transform medicine and science EXCELLENCE - Achieving world-class results INNOVATION - Leading with discovery and creative solutions STEWARDSHIP - Caring for and enhancing the resources entrusted to us What do we have to offer? JAX offers a dynamic and supportive work environment, competitive salaries and a comprehensive benefits package including a medical plan, outstanding retirement plan, generous paid time off and tuition reimbursement. JAX offers an MBA program, a fitness center with an award winning wellness program, and a fully operational primary care facility available to employees and their families. Most importantly, every position contributes to JAX’s mission of discovering precise genomic solutions for human disease and empowering the global biomedical community in our shared quest to improve human health. The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws. Learn more about at opportunities at JAX at http://www.jax.org/careers Job Location Bar Harbor, Maine, United States Position Type Full-Time/Regular [Click Here to Access the Original Job Post]
The Ke Lab invites one Associate Research Scientist to join at The Jackson Laboratory in Bar Harbor, Maine. The Ke Lab focuses on RNA, a central node of genetic information flow from DNA to protein (https://www.jax.org/research-and-faculty/faculty/shengdong-ke ). Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanism of RNA, the Ke lab utilizes multidisciplinary approaches, including cutting-edge computational biology, biochemistry, innovative bio-technologies, genetics and molecular biology. We are especially interested in m6A RNA biology: 1) the fundamental mechanism of m6A RNA biology, and 2) the biological effects of m6A regulation in nerve system, using mouse and human iPS models. (References: 1] Ke, S. et al. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover, Genes & Development 2017, 31: 990-1006; 2] Ke, S. et al. A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation, Genes & Development 2015, 29:2037-53.) Qualified candidates would be self-motivated and career oriented individuals, have a genuine interest in addressing complex biological questions and a PhD or MD with background in one or multiple areas, including computational biology, biochemistry, molecular biology, biotechnology, neurosciences, immunology, stem cell, or cancer biology. Skills of quantitative programming or biochemistry are particularly preferred but not required. Key Responsibilities:
- Development, optimization and validation of experimental design.
- Synthesis of data into succinct, reproducible and understandable reports/presentations for distribution.
- Work with scientific and support staff to assist in grant preparation, with particular reference to experimental design, samples sizes, and statistical/analytical methodology.
- Working with other researchers to use and develop end product.
- Applying for grants to continue/expand research.
- PhD in genetics, biochemistry, molecular biology, cell biology, computational biology or other relevant field
- Three (3) years of postdoctoral training or equivalent research experience, and demonstrated meritorious scientific performance.
- Strong publication record (two or more peer-reviewed publications).
- Ability to integrate and apply feedback in a professional manner, prioritize and drive to results with a high emphasis on quality, and work as part of a team.
- Laboratory background with appropriate work experience or with proven ability for practical application of theoretical knowledge.
- Proven ability to analyze and synthesize information, and demonstrated resourcefulness in finding appropriate solutions to problems and initiative in presenting alternatives and implementing solutions to ensure effective change and/or eliminate or mitigate potential negative effects.
- Exceptional organizational and project management skills, including the ability to plan, schedule, and successfully carry out multiple projects at the same time to successful conclusion with minimal supervision.
- Quality orientated including delivering accuracy and attention to detail.
Requeriments :
Skills :
Areas :
Additional Info:
A cover letter outlining general interests, and career goals should be submitted with CV/Resume as one document to consider application complete. About us: The Jackson Laboratory, (JAX, www.jax.org) is a nonprofit biomedical research institute with over 1,800 employees whose mission is to discover precise genomic solutions for human disease and empower the global biomedical community in the shared quest to improve human health. JAX’s research facility in Bar Harbor, Maine is a National Cancer Institute-designated Cancer Center and a world-renowned expert in mammalian genetics. JAX also has facilities in Sacramento, California, and The Jackson Laboratory for Genomic Medicine in Farmington, Connecticut. JAX employees work in a collaborative, value-driven and team-based environment where the focus is on advancing science and improving patients’ lives. Researchers apply genetics to increase the understanding of human disease and advance treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. The Jackson Laboratory's 43-acre scenic campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums and galleries. Our Values: INTEGRITY - Courage and commitment to do what is right PEOPLE - Inspiring our people to enhance the health of all ONE TEAM - Unified by our promise to transform medicine and science EXCELLENCE - Achieving world-class results INNOVATION - Leading with discovery and creative solutions STEWARDSHIP - Caring for and enhancing the resources entrusted to us What do we have to offer? JAX offers a dynamic and supportive work environment, competitive salaries and a comprehensive benefits package including a medical plan, outstanding retirement plan, generous paid time off and tuition reimbursement. JAX offers an MBA program, a fitness center with an award winning wellness program, and a fully operational primary care facility available to employees and their families. Most importantly, every position contributes to JAX’s mission of discovering precise genomic solutions for human disease and empowering the global biomedical community in our shared quest to improve human health. The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws. Learn more about at opportunities at JAX at http://www.jax.org/careers Job Location Bar Harbor, Maine, United States Position Type Full-Time/Regular [Click Here to Access the Original Job Post]