Job Description:
The proposed project will provide for the first time a bioinformatics model of and means of utilizing the genetic and plasma complotype markers that best correlate with baseline and induced complement activation in plasma. We have evolved the concept of the complotype over the last 5 years, publishing several key papers and highly cited reviews to establish the concept in the field (1-4). The complotype describes the set of common polymorphisms in complement proteins and regulators that an individual inherits; we have advanced the hypothesis that the complotype dictates the capacity for complement activation in an individual which in turn influences risk of inflammatory and/or infectious disease. For some individual polymorphisms the disease risk is proven and can be explained by its functional consequences. For others, associations are less obvious and may require co-incident inheritance of other polymorphisms in order to impact function. Complement is, by definition, a complex system and an understanding of how the global complotype impacts activity, activation and regulation in an individual requires a systems approach. Critically, and so far untested, the complotype may also affect an individual's response to anti-complement drugs and impact effective dosing. The proposed research fits the mission of the newly established Systems Immunity URI and will provide excellent training in complement genetics and biochemistry and in analysis of complex systems.
This job comes from a partnership with Science Magazine and
Additional Info:
[Click Here to Access the Original Job Post]
The proposed project will provide for the first time a bioinformatics model of and means of utilizing the genetic and plasma complotype markers that best correlate with baseline and induced complement activation in plasma. We have evolved the concept of the complotype over the last 5 years, publishing several key papers and highly cited reviews to establish the concept in the field (1-4). The complotype describes the set of common polymorphisms in complement proteins and regulators that an individual inherits; we have advanced the hypothesis that the complotype dictates the capacity for complement activation in an individual which in turn influences risk of inflammatory and/or infectious disease. For some individual polymorphisms the disease risk is proven and can be explained by its functional consequences. For others, associations are less obvious and may require co-incident inheritance of other polymorphisms in order to impact function. Complement is, by definition, a complex system and an understanding of how the global complotype impacts activity, activation and regulation in an individual requires a systems approach. Critically, and so far untested, the complotype may also affect an individual's response to anti-complement drugs and impact effective dosing. The proposed research fits the mission of the newly established Systems Immunity URI and will provide excellent training in complement genetics and biochemistry and in analysis of complex systems.
This job comes from a partnership with Science Magazine and
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Additional Info:
[Click Here to Access the Original Job Post]