Job Description:
JOB DESCRIPTION A postdoctoral research position is available immediately in the Molecular Mechanisms Section, Laboratory of Retinal Cell & Molecular Biology, National Eye Institute (NEI), NIH, to study the biochemical mechanisms of retinoid metabolism and isomerization in the retina/retinal pigment epithelium (RPE). The Molecular Mechanisms Section conducts exciting research into retina/RPE retinoid/carotenoid metabolism and derangements thereof that result in blindness, and other specialized aspects of retina/RPE biochemistry (for more information please see http://www.nei.nih.gov/intramural/mol_mech_sec.asp). Our focus is on the vitamin A visual cycle that provides the 11-cis retinal chromophore essential for vision, to provide a better understanding of vitamin A metabolism in vision and in retinal degenerations, and to develop therapies to treat derangements of retinoid metabolism. Current projects include structural and biochemical studies on the enzymatic mechanism of RPE65/retinol isomerase, analysis of RPE65 knockin mouse models to elucidate chromophore requirements for photoreceptor viability, RPE biochemistry, and the biochemistry of bisretinoid accumulation in retinal diseases. We have access to a wide range of NEI core facilities and resources, including mass spectrometry, genetic engineering, biological imaging, visual function, bioinformatics, etc., and to much additional research expertise at the NIH Bethesda campus. Training will be provided as required.
To submit your application, please click on the "APPLY" button. Please send CV and bibliography, a summary of research accomplishments, a statement of research interests and career goals, and the names and addresses of at least three references to: Dr. T. Michael Redmond.
DESIRED SKILLS AND EXPERIENCE
We are seeking well-trained applicants with a Ph.D. or M.D./Ph.D., and a strong background in biochemistry or chemistry, and/or molecular biology, and up to 5 years of postdoctoral experience in cognate areas of research. The successful candidate will be highly motivated to succeed, be able to work both independently and as part of a team, and have excellent verbal/written communications and organizational skills. The successful candidate is expected to take full advantage of an exciting and stimulating scientific environment at NIH.
ABOUT THE EMPLOYER
The Intramural Research Program of the National Eye Institute (NEI) conducts research into blinding eye diseases, visual disorders, and mechanisms of visual function. The NEI is a component of the National Institutes of Health (NIH) located in Bethesda, MD, close to Washington, DC. NIH’s mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, and about 6000 scientists and clinicians work in its different institutes and centers, mostly in Bethesda.
Additional Info:
[Click Here to Access the Original Job Post]
JOB DESCRIPTION A postdoctoral research position is available immediately in the Molecular Mechanisms Section, Laboratory of Retinal Cell & Molecular Biology, National Eye Institute (NEI), NIH, to study the biochemical mechanisms of retinoid metabolism and isomerization in the retina/retinal pigment epithelium (RPE). The Molecular Mechanisms Section conducts exciting research into retina/RPE retinoid/carotenoid metabolism and derangements thereof that result in blindness, and other specialized aspects of retina/RPE biochemistry (for more information please see http://www.nei.nih.gov/intramural/mol_mech_sec.asp). Our focus is on the vitamin A visual cycle that provides the 11-cis retinal chromophore essential for vision, to provide a better understanding of vitamin A metabolism in vision and in retinal degenerations, and to develop therapies to treat derangements of retinoid metabolism. Current projects include structural and biochemical studies on the enzymatic mechanism of RPE65/retinol isomerase, analysis of RPE65 knockin mouse models to elucidate chromophore requirements for photoreceptor viability, RPE biochemistry, and the biochemistry of bisretinoid accumulation in retinal diseases. We have access to a wide range of NEI core facilities and resources, including mass spectrometry, genetic engineering, biological imaging, visual function, bioinformatics, etc., and to much additional research expertise at the NIH Bethesda campus. Training will be provided as required.
To submit your application, please click on the "APPLY" button. Please send CV and bibliography, a summary of research accomplishments, a statement of research interests and career goals, and the names and addresses of at least three references to: Dr. T. Michael Redmond.
DESIRED SKILLS AND EXPERIENCE
We are seeking well-trained applicants with a Ph.D. or M.D./Ph.D., and a strong background in biochemistry or chemistry, and/or molecular biology, and up to 5 years of postdoctoral experience in cognate areas of research. The successful candidate will be highly motivated to succeed, be able to work both independently and as part of a team, and have excellent verbal/written communications and organizational skills. The successful candidate is expected to take full advantage of an exciting and stimulating scientific environment at NIH.
ABOUT THE EMPLOYER
The Intramural Research Program of the National Eye Institute (NEI) conducts research into blinding eye diseases, visual disorders, and mechanisms of visual function. The NEI is a component of the National Institutes of Health (NIH) located in Bethesda, MD, close to Washington, DC. NIH’s mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, and about 6000 scientists and clinicians work in its different institutes and centers, mostly in Bethesda.
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Additional Info:
[Click Here to Access the Original Job Post]