Job ID:
Job date: 2014-12-19
End Date:
Company : Wellcome Trust Sanger Institute Country : Role : Postdoc
Job date: 2014-12-19
End Date:
Company : Wellcome Trust Sanger Institute Country : Role : Postdoc
Job Description:
We are looking for a creative and motivated Postdoctoral Fellow to join our dynamic, multi-disciplinary research team investigating the mechanisms of colonisation resistance to Clostridium difficile infection.
Clostridium difficile is the most common cause antibiotic-associated diarrhea and is serious pathogen in healthcare facilities worldwide. The indigenous intestinal microbiota normally protects against C. difficile disease, but individuals become susceptible after antibiotic therapy damages the resident microbiota. Infection often leads to long-term diarrhoea and relapsing disease that is often refractory to further antibiotic therapy but is effectively resolved with restoration of the microbiota using faecal transplantation. The Host-Microbiota Interactions Laboratory is developing methods to identify and characterise protective bacteria from healthy individuals that can be used to treat C. difficile patients in an emerging area of medicine called bacteriotherapy. The proposed research will utilise cutting edge genomic and proteomic technologies in combination with in vitro and murine models (germ free, humanised microbiota) to study the basic biology of colonisation resistance to C. difficile. This work has the potential to guide the development of novel therapeutic approaches for the treatment of recurrent C. difficile infection and potentially for other intestinal diseases precipitated by antibiotics or caused by pathogens
Essential Skills
• A PhD in microbiology, microbiota, microbial ecology, genomics or mouse models
• Outstanding personal initiative and communication
• Strong publication record in peer-reviewed journals
Ideal Skills
• Genome analysis experience
• Anaerobic microbiology
• Developing Mouse models
• Germ free mice work
• Knowledge of intestinal immune system, particularly in response to infection
Other information
The Genome Campus is a 100-acre estate south of Cambridge in the grounds of Hinxton Hall and is home to the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EBI). The site has become the British hub of biomedical science. The Campus is also home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.
In addition to its peaceful location the campus offers excellent facilities including a start of the art data centre, gym, two cafes, a nursery, dining facilities, a cycle to work scheme, car sharing and free campus buses from various locations around Cambridge.
Learning, development and networking are other important aspects of life on campus. There are a range of scientific seminars with our own and invited speakers, scientific group meetings and skills development workshops.
Our benefits package includes 25 days annual leave (increasing 1 day for every year’s service to a maximum of 30 days), premier private healthcare and a defined benefits pension scheme.
Please include a covering letter and CV with your application.
Closing date for applications: 18th January 2015
Additional Info:
[Click Here to Access the Original Job Post]
We are looking for a creative and motivated Postdoctoral Fellow to join our dynamic, multi-disciplinary research team investigating the mechanisms of colonisation resistance to Clostridium difficile infection.
Clostridium difficile is the most common cause antibiotic-associated diarrhea and is serious pathogen in healthcare facilities worldwide. The indigenous intestinal microbiota normally protects against C. difficile disease, but individuals become susceptible after antibiotic therapy damages the resident microbiota. Infection often leads to long-term diarrhoea and relapsing disease that is often refractory to further antibiotic therapy but is effectively resolved with restoration of the microbiota using faecal transplantation. The Host-Microbiota Interactions Laboratory is developing methods to identify and characterise protective bacteria from healthy individuals that can be used to treat C. difficile patients in an emerging area of medicine called bacteriotherapy. The proposed research will utilise cutting edge genomic and proteomic technologies in combination with in vitro and murine models (germ free, humanised microbiota) to study the basic biology of colonisation resistance to C. difficile. This work has the potential to guide the development of novel therapeutic approaches for the treatment of recurrent C. difficile infection and potentially for other intestinal diseases precipitated by antibiotics or caused by pathogens
Essential Skills
• A PhD in microbiology, microbiota, microbial ecology, genomics or mouse models
• Outstanding personal initiative and communication
• Strong publication record in peer-reviewed journals
Ideal Skills
• Genome analysis experience
• Anaerobic microbiology
• Developing Mouse models
• Germ free mice work
• Knowledge of intestinal immune system, particularly in response to infection
Other information
The Genome Campus is a 100-acre estate south of Cambridge in the grounds of Hinxton Hall and is home to the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EBI). The site has become the British hub of biomedical science. The Campus is also home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.
In addition to its peaceful location the campus offers excellent facilities including a start of the art data centre, gym, two cafes, a nursery, dining facilities, a cycle to work scheme, car sharing and free campus buses from various locations around Cambridge.
Learning, development and networking are other important aspects of life on campus. There are a range of scientific seminars with our own and invited speakers, scientific group meetings and skills development workshops.
Our benefits package includes 25 days annual leave (increasing 1 day for every year’s service to a maximum of 30 days), premier private healthcare and a defined benefits pension scheme.
Please include a covering letter and CV with your application.
Closing date for applications: 18th January 2015
Requeriments :
Skills :
Areas :
Additional Info:
[Click Here to Access the Original Job Post]