Job ID: 5279
Job date: 2016-03-15
End Date:
Company : Sheffield Institute for Translational Neuroscience Country : Role : Research Scientist
Job date: 2016-03-15
End Date:
Company : Sheffield Institute for Translational Neuroscience Country : Role : Research Scientist
Job Description:
The Team
The Centre for Genome Translation is part of a rapidly growing base of genome medicine expertise at Sheffield. We deliver, as part of Genome England/Higher Education England/National Health Service, an MSc in Genome Medicine. In addition, Sheffield is part of the GEL/NHS Yorkshire Genome Medicine Centre. We are growing an interdisciplinary team of genome medicine experts to prioritise new target genes and processes that lead to neurodegenerative disorders such as Alzheimer’s, Parkinson’s and Amyotrophic Lateral Sclerosis.
The Project
The Genome Translation Commons is an open access resource developed in collaboration with groups at Harvard Stem Cell Institute, Harvard T.H. Chan School of Public Health and Harvard Medical School. It manages and shares growing resources of biomedical and human sequence and functional genomics data to develop network and computational functional models for drug discovery. With the aim of identification and integration of existing resources to allow for deep exploration of neurodegenerative disease networks, we integrate functional data, exomes and genomes of study participants, and use this framework to identify and prioritize potential therapeutics.
Your Role
Your role will be as a leader within the Neurodegenerative Disease Genome Translation Program. You will direct overall design and implementation of the Genome Translation Commons, and will drive and oversee aspects of scientific implementation of our research programme.
You will provide project management and scientific insight to help develop and co-ordinate the rollout of the Genome Translation Commons - to enable ideas to become operational and to grow the system in close liaison with the drug targeting community. This will involve determining the needs of the community, translating these into implementable tools and systems, and providing the community with the vision and means by which they can access these tools.
You will work closely with the Centre for Genome Translation team, our programmer(s) and curator(s) to manage delivery of this feature set and data content as appropriate for the research questions we wish to address. For this aspect of your role, you will leverage your understanding of human genetics, your experience of analyzing high throughput biomedical data, management of software developers, keen scientific and quantitative skills, and broad social skills.
A primary task will be oversight of a team of programmers and a data curator, to drive establishment of commons services, data acquisition, annotation, analysis and development of workflows and integration pipelines in the context of industrial and academic partners. You will work with data from humans, and model organisms and human transdifferentiated cell lines to action genotype-phenotype predictions.
You will also have opportunity to provide leadership in computational and statistical analysis of NGS sequencing studies, be able to contribute technically and logistically to existing collaborations in international consortia, and be able to provide insight and intellectual leadership for integration of exome, whole genome genetic variation and NGS gene expression data into pathway network analysis. You will use internally developed tools and work closely with the software team to provide feedback on the development of these tools.
You will have the opportunity to support and lead research in a team focused on questions in targeting neurodegenerative disease. With an appreciation of approaches to incorporate ‘omics data into clinical practice, you will support interaction with external research consortia to develop bioinformatics analysis and interpretation of genomic data in collaboration with computational systems biologists, bioinformatics analysts, machine learning specialists, programmers, biomedical researchers and clinicians in academia and industry.
Key to your success will be the ability to design and develop approaches to address areas such as the prediction of patient outcomes, modelling of drug response, interpretation of functional screen data, integrative genomic analysis and implementation of algorithms for interrogating and interpreting complex genomic data.
Teaching - if appointed as lecturer you may be required to teach graduate level courses and contribute to graduate trainee guidance
You have a PhD in relevant scientific domain, commitment to open source development and are effective at working with collaborators located in the UK, Europe and USA. You have vision and know-how in addressing data sharing, and are aware of the social impact of the work that you will be contributing to. A natural leader, you will be able to develop excellent rapport and you must be prepared to provide lucid explanation of the role of genomics in medicine and drug discovery.
You will work closely with the project team to develop and carry out analytical deliverables and strategies. You thrive in an academic/professional atmosphere, where interdisciplinary teams are central to project success.Job Information Position Type: Research Associate Start Date: ASAP Duration: Full Time Status: openContact InformationSheffield Institute for Translational Neuroscience
Neuroscience
Winston Hide
winhide#$at%^sheffield.ac.ukhttps://wordpress.com/page/hidelab.wordpress.com/16How To Apply:email to me directly
Additional Info:
[Click Here to Access the Original Job Post]
ISCB Job Board
Team Leader in Translational BioinformaticsSheffield Institute for Translational NeuroscienceNeuroscienceUnited Kingdom -Yorkshire-Sheffield The Sheffield Institute for Translational Neuroscience is looking for an exceptional candidate to take on a leadership role within its rapidly growing team at the Centre for Genome Translation as a Senior Research Associate.The Team
The Centre for Genome Translation is part of a rapidly growing base of genome medicine expertise at Sheffield. We deliver, as part of Genome England/Higher Education England/National Health Service, an MSc in Genome Medicine. In addition, Sheffield is part of the GEL/NHS Yorkshire Genome Medicine Centre. We are growing an interdisciplinary team of genome medicine experts to prioritise new target genes and processes that lead to neurodegenerative disorders such as Alzheimer’s, Parkinson’s and Amyotrophic Lateral Sclerosis.
The Project
The Genome Translation Commons is an open access resource developed in collaboration with groups at Harvard Stem Cell Institute, Harvard T.H. Chan School of Public Health and Harvard Medical School. It manages and shares growing resources of biomedical and human sequence and functional genomics data to develop network and computational functional models for drug discovery. With the aim of identification and integration of existing resources to allow for deep exploration of neurodegenerative disease networks, we integrate functional data, exomes and genomes of study participants, and use this framework to identify and prioritize potential therapeutics.
Your Role
Your role will be as a leader within the Neurodegenerative Disease Genome Translation Program. You will direct overall design and implementation of the Genome Translation Commons, and will drive and oversee aspects of scientific implementation of our research programme.
You will provide project management and scientific insight to help develop and co-ordinate the rollout of the Genome Translation Commons - to enable ideas to become operational and to grow the system in close liaison with the drug targeting community. This will involve determining the needs of the community, translating these into implementable tools and systems, and providing the community with the vision and means by which they can access these tools.
You will work closely with the Centre for Genome Translation team, our programmer(s) and curator(s) to manage delivery of this feature set and data content as appropriate for the research questions we wish to address. For this aspect of your role, you will leverage your understanding of human genetics, your experience of analyzing high throughput biomedical data, management of software developers, keen scientific and quantitative skills, and broad social skills.
A primary task will be oversight of a team of programmers and a data curator, to drive establishment of commons services, data acquisition, annotation, analysis and development of workflows and integration pipelines in the context of industrial and academic partners. You will work with data from humans, and model organisms and human transdifferentiated cell lines to action genotype-phenotype predictions.
You will also have opportunity to provide leadership in computational and statistical analysis of NGS sequencing studies, be able to contribute technically and logistically to existing collaborations in international consortia, and be able to provide insight and intellectual leadership for integration of exome, whole genome genetic variation and NGS gene expression data into pathway network analysis. You will use internally developed tools and work closely with the software team to provide feedback on the development of these tools.
You will have the opportunity to support and lead research in a team focused on questions in targeting neurodegenerative disease. With an appreciation of approaches to incorporate ‘omics data into clinical practice, you will support interaction with external research consortia to develop bioinformatics analysis and interpretation of genomic data in collaboration with computational systems biologists, bioinformatics analysts, machine learning specialists, programmers, biomedical researchers and clinicians in academia and industry.
Key to your success will be the ability to design and develop approaches to address areas such as the prediction of patient outcomes, modelling of drug response, interpretation of functional screen data, integrative genomic analysis and implementation of algorithms for interrogating and interpreting complex genomic data.
Teaching - if appointed as lecturer you may be required to teach graduate level courses and contribute to graduate trainee guidance
You have a PhD in relevant scientific domain, commitment to open source development and are effective at working with collaborators located in the UK, Europe and USA. You have vision and know-how in addressing data sharing, and are aware of the social impact of the work that you will be contributing to. A natural leader, you will be able to develop excellent rapport and you must be prepared to provide lucid explanation of the role of genomics in medicine and drug discovery.
You will work closely with the project team to develop and carry out analytical deliverables and strategies. You thrive in an academic/professional atmosphere, where interdisciplinary teams are central to project success.Job Information Position Type: Research Associate Start Date: ASAP Duration: Full Time Status: openContact InformationSheffield Institute for Translational Neuroscience
Neuroscience
Winston Hide
winhide#$at%^sheffield.ac.ukhttps://wordpress.com/page/hidelab.wordpress.com/16How To Apply:email to me directly
Requeriments :
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Additional Info:
[Click Here to Access the Original Job Post]