Job date: 2016-05-16
End Date:
Company : CLARITAS GENOMICS, INC Country : Role : Research Scientist
Claritas Genomics is seeking a motivated Bioinformatics Analyst or scientist to help accelerate the integration of next-generation sequencing into clinical diagnostics and precision care. Within the Bioinformatics Group, the candidate will help with processing of clinical production samples, conduct validation studies of new assays, and monitor quality control and performance metrics of production operations. The candidate will be responsible for rigorous data analysis and clear informatics communications. While the primary need is for an entry-level individual, qualified applicants at all levels will be considered. The unique mix of genetic and sequencing technologies available at Claritas will provide opportunities for informatics analysts/scientists seeking the broadest experience available.
Responsibilities: As a member of the Bioinformatics Team, the candidate will:
Manage the sample flow through clinical production bioinformatics pipeline, including sample tracking and communication with clinical interpretation teamWork closely with software, clinical lab and R&D groups to support process automation and data analysisLead data analysis and write-up for validation of new/updated assaysWrite and maintain SOP’s (Standard Operating Procedures) to describe production bioinformatics workflowsWrite custom analysis code and contribute to production pipeline codePerform analyses of software pipelines including assessment of quality control metrics, variant calling, scoring and filtering, and integration of orthogonal confirmation strategiesDesign, plan, and perform specific bioinformatics experiments and projects for technical feasibility assessment, product development, and assay validationDevelop, characterize and optimize bioinformatics tools and methods to support existing and emerging productsEducational Requirements:
Bachelors or Masters in computer science, computational biology, biostatistics, bioinformatics, or related fieldDesired Skills and Experience:
Proficiency working in UNIX/Linux platformsFamiliarity with commonly used Bioinformatics tools and APIs: SAMtools, GATK, Picard, Bedtools, IGVFamiliarity working in Amazon AWS environment a strong plusScripting experience in Python, R or similar technology on a UNIX platformExperience coding in Java and familiarity with team-based software development, agile development, and test-driven development are desirableFamiliarity with commonly used reference databases, tools, and browsers: Cosmic, ClinVar, Entrez, Ensembl Genes, ClinGen, Encode, HGMD, 1000 Genomes, ESP, HapMap, UCSC Genome Browser, Annovar, Alamut, PolyPhen, SIFTCan work independently with minimal supervision; proven and solid problem-solving skillsExcellent written and verbal communication skills; must be able to achieve success in a multidisciplinary team environmentExperience in a clinical molecular diagnostic laboratory or regulated product development environment is preferredAbility to succeed in a fast-paced and dynamic work environmentJob Type: Full-time
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