Postdoctoral Fellow – Viral evolution and broadly neutralizing antibody responses in HIV infection

Job Description:

Job Title:        Postdoctoral Fellow to study viral evolution and broadly neutralizing antibody responses in HIV infection 

Salary Plan:   NIH and institutional funding

Lab:    Allen              

Direct Supervisor: Todd Allen

Employing Hospital and Department:       

Ragon Institute of MGH, MIT, and Harvard

Minimum degree and field of knowledge: PhD, MD

Years experience required:  0 – 2 years experience

Summary:

The Ragon Institute of MGH, MIT and Harvard located in Kendall Square in Cambridge, MA has an opening in the Allen laboratory (http://www.ragoninstitute.org/portfolio-item/allen-lab/) for a highly motivated postdoctoral fellow to study the role of HIV sequence evolution in the development of broadly neutralizing antibodies.

This position requires a Ph.D. or an M.D. with a background in humoral immunity, evolutionary biology, and/or bioinformatics. Research will focus on elucidating the role that viral evolution and escape from humoral immune responses plays in the development and maturation of broadly neutralizing antibodies to HIV. Efforts will include application of next generation sequencing (NGS) technologies to address these questions and development of advanced comparative genomic tools for the analysis of large viral genomic NGS datasets.

Goals are to understand the role of HIV sequence evolution in the development of broadly neutralizing antibodies and apply this knowledge to design the effective components of an HIV vaccine.

State-of-the-art facilities are available within an exceptionally energetic research setting.

Job Duties:

Under the direction of the principal investigator the applicant independently carries out daily activities of the laboratory.

Performs molecular biology and cell-based assays utilizing standard techniques (DNA/RNA extraction and analysis, standard and quantitative PCR, site-directed mutagenesis, neutralization assays, ELISAs) Next-generation Illumina library construction and sequencing Bioinformatic analysis of conventional bulk and next-generation sequence data Develop advanced comparative genomic tools for the analysis of large viral genomic NGS datasets Detailed documentation of the experimental work

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Requeriments :

• Doctorate Degree
• M.Sc. or higher Degree in Bioinformatics

Skills :

• Bioinformatics
• Biology
• Next Generation Sequencing

Areas :

• Bioinformatics

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Additional Info:

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