Job date: 2016-11-30
End Date:
Company : Cancer Research UK Beatson Institute Country : Role : Postdoc
Initial 3 year fixed term contract (with possibility of up to 2 year extension)
The role of the transfer RNA repertoire in generating secretory phenotypes during epithelial homeostasis and cancer
We are seeking an ambitious postdoctoral fellow to work on a project to investigate how genetic alterations to the tRNA repertoire influence ribosome function to generate secretory phenotypes during intestinal differentiation and fibroblast activation, and how this can generate microenvironments that promote cancer progression. This programme will be conducted in close collaboration with Prof. Martin Bushell at the MRC Toxicology Unit in Leicester. The successful candidate will have an interest in elucidating molecular and cellular mechanisms through which the cell’s mRNA translation machinery can influence secretory processes and how this affects cell differentiation and cancer progression in vivo.
This project will be of interest for those seeking to work on novel aspects of cell biology in the context of cancer, and who wish to undertake cross-disciplinary approaches to medical science and cancer research. In particular we are seeking applicants who have completed their PhD. training and whose ambition is to obtain an independent group leader/PI position in 5-6 years’ time.
You will have successfully completed a PhD in a field relevant to mRNA biology, translational control, cell signalling and/or cell adhesion/migration. You will have published primary research papers (or have these papers in revision/in press) on relevant topics and preferably have skills in microscopy, cell and molecular biology as well as some knowledge of cancer models.
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Profs Jim Norman & Owen Sansom, In collaboration with Prof Martin Bushell (MRC, Leicester). Cancer Research UK Beatson Institute in Glasgow is one of Europe's leading cancer research centres. It supports cutting edge research into the molecular mechanisms of cancer development. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies with special emphasis on imaging, metabolomics and in vivo models of cancer. [Click Here to Access the Original Job Post]