Job ID: 54045
Job date: 2017-03-10
End Date:
Company : Oregon Health & Science University Country : Role : Research Scientist
Job date: 2017-03-10
End Date:
Company : Oregon Health & Science University Country : Role : Research Scientist
Job Description:
A bioinformatics specialist position is available immediately in the laboratory of Dr. Brian J. O’Roak, Department of Molecular and Medical Genetics at Oregon Health & Science University (OHSU) for highly motivated individuals. This position requires a skilled bioinformaticist with experience processing and analyzing “next-generation” sequencing datasets. Projects will include exploring the role of germline mutations and somatic mosaicism in autism and other neurodevelopmental disorders (e.g. neural tube defects), for which funding currently exists. Individual will conduct primary and secondary analyses that will likely require writing custom scripts/programs and running standard best practice computational pipelines in an HT Condor environment. OHSU is a highly collaborative environment. Researchers will have the opportunity to interact/collaborate with researchers from genetics, neurosciences, the new computational biology program, and clinical research programs focused on neurodevelopmental disorders. Moreover, OHSU has recently signed a unique collaborative agreement with Intel focused on developing the next-generation of computational approaches for human genetics; candidates with interest in this area of research are especially encouraged to apply.
Additional Info:
Work Unit Description: The genetic intractability of complex genetic heterogeneous disorders, such as autism spectrum disorder (ASD), intellectual disability (ID), and broadly defined developmental delay, has been challenged in recent years; first by the application of genomewide platforms to detect copy number and more recently sequencing of the entire protein-coding genome (aka exome). Recent exome sequencing studies of families with simplex or “sporadic” ASD and ID has highlighted the importance of de novo mutations and led to the discovery of novel candidate genes. Moreover, genetic risk has been now shown to span what are generally considered distinct clinical disorders. Highlights of Dr. O’Roak’s past research successes include: pioneering trio-based exome sequencing in simplex autism and developing new technologies for rapid and economical targeted resequencing. We are building on this experience by forming a strong and diverse research group focused on developing and implementing cutting-edge methods and technologies for discovery and replication, molecular diagnosis, functional dissection of pathways, and targeted therapeutics for neurodevelopmental and related disorders. This work has the potential to dramatically improve the lives of individuals affected with these currently untreatable disorders through early intervention and biologically based personal therapies. -FTE: 1.0 FTE, Full Time -Schedule: Variable -Salary Range: Commensurate with Experience -Location: Portland, OR (Marquam Hill) -Job Type: Research Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu. Apply online. Please attach CV/Resume, cover letter and list of 3 references.[Click Here to Access the Original Job Post]
A bioinformatics specialist position is available immediately in the laboratory of Dr. Brian J. O’Roak, Department of Molecular and Medical Genetics at Oregon Health & Science University (OHSU) for highly motivated individuals. This position requires a skilled bioinformaticist with experience processing and analyzing “next-generation” sequencing datasets. Projects will include exploring the role of germline mutations and somatic mosaicism in autism and other neurodevelopmental disorders (e.g. neural tube defects), for which funding currently exists. Individual will conduct primary and secondary analyses that will likely require writing custom scripts/programs and running standard best practice computational pipelines in an HT Condor environment. OHSU is a highly collaborative environment. Researchers will have the opportunity to interact/collaborate with researchers from genetics, neurosciences, the new computational biology program, and clinical research programs focused on neurodevelopmental disorders. Moreover, OHSU has recently signed a unique collaborative agreement with Intel focused on developing the next-generation of computational approaches for human genetics; candidates with interest in this area of research are especially encouraged to apply.
Job Requirements
Required Qualifications: -Bachelor's Degree with major courses in field of research and 1 to 3 years of experience in computer science or bioinformatics. -Experience with whole-exome or genome sequencing. -Fluent in one or more programing languages. -Good communication skills. -Able to work in a team and effectively communicate results to other members. Preferred Qualifications: -Master's degree in related field. -Intensive training in the areas of genetics/genomics, computer science, bioinformatics. -Familiarity with statistics, population and gene databases, in silico predictive algorithms, structural variation tools, genetics and genomics. -Experience with RNA-seq and ChIP-seq. -Linux cluster management and architecture.Requeriments :
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Additional Info:
Work Unit Description: The genetic intractability of complex genetic heterogeneous disorders, such as autism spectrum disorder (ASD), intellectual disability (ID), and broadly defined developmental delay, has been challenged in recent years; first by the application of genomewide platforms to detect copy number and more recently sequencing of the entire protein-coding genome (aka exome). Recent exome sequencing studies of families with simplex or “sporadic” ASD and ID has highlighted the importance of de novo mutations and led to the discovery of novel candidate genes. Moreover, genetic risk has been now shown to span what are generally considered distinct clinical disorders. Highlights of Dr. O’Roak’s past research successes include: pioneering trio-based exome sequencing in simplex autism and developing new technologies for rapid and economical targeted resequencing. We are building on this experience by forming a strong and diverse research group focused on developing and implementing cutting-edge methods and technologies for discovery and replication, molecular diagnosis, functional dissection of pathways, and targeted therapeutics for neurodevelopmental and related disorders. This work has the potential to dramatically improve the lives of individuals affected with these currently untreatable disorders through early intervention and biologically based personal therapies. -FTE: 1.0 FTE, Full Time -Schedule: Variable -Salary Range: Commensurate with Experience -Location: Portland, OR (Marquam Hill) -Job Type: Research Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu. Apply online. Please attach CV/Resume, cover letter and list of 3 references.[Click Here to Access the Original Job Post]