Job date: 2016-02-23
End Date:
Company : Imagine Institute for Genetic Diseases Country : Role : Postdoc
Two postdoctoral positions are available at the new Clinical Bioinformatics lab at Imagine Institute for Genetic diseases, headed by Dr. Antonio Rausell.
Job description
Imagine is an interdisciplinary research center focused on human genetic diseases located at the Necker Hospital campus in the heart of Paris. Imagine is affiliated with the Université Paris Descartes (Sorbonne Paris Cité), the INSERM French National Institute for Medical Research and the Paris Public Hospitals Group (Assistance Publique-Hôpitaux de Paris). Imagine has recently launched a new research Laboratory in Clinical Bioinformatics under the direction of Dr. Antonio Rausell. The laboratory develops statistical methods and bioinformatics pipelines with a clinical focus on the following two main research lines:
1) Computational assessment and prioritization of human rare genetic variants with a potential clinical impact and application to disease-specific sequencing projects. Both coding and non-coding variants will be considered. The work will integrate large-scale genome/exome sequencing, transcriptomes (RNA-seq), high-throughput proteomics (mass spectrometry), immune phenotyping and clinical datasets both from public and in-house sources. Development of predictive tools will include machine-learning techniques such as Bayesian classifiers and SVMs. The goal is implementing software to help decision-making at the clinic.
2) Statistical analyses of high-dimensional single-cell data of human cells (mainly single-cell RNA-seq) with a focus on immune disorders and susceptibility to infectious diseases. Computational methods will be developed to cope with different noise sources and complex experimental designs: e.g. multiple conditions/stimuli and time points, simultaneous analyses of host and intracellular pathogens and several read-outs from the same cells, e.g.: genome and transcriptome, transcriptome and proteome, etc. The goal is the identification of cell markers with clinical value for diagnosis and treatment.
In this context, the Clinical Bioinformatics lab is hiring two postdocs with complementary expertise in order to i) take the lead in one of the two previous research lines, ii) being able to assist the other line with specific skills if needed, and iii) set up the suite of common data and pipelines to build the core’s lab. As someone said before: “we hire smart people so they can tell us what to do”.
Requeriments :
Skills :
Areas :
Additional Info:
[Click Here to Access the Original Job Post]