Job Description:
This is a full-time position based in our in Cambridge, MA. Responsibilities: -Working with our team of scientists and informatics staff on continued development and implementation of the tumor vs germline analysis based on our informatics pipeline applied to whole exome and whole genome datasets. -This is a client-facing role and requires exceptional leadership skills, innovative/strategic thinking complimented by a strong, broad experience of Bioinformatics, preferably from within a large genomics, pharmaceutical or biotech environment. -The Associate Director is responsible for a team, each member an expert specializing in their own therapeutic discipline. -The AD provides supports and represents the department, establishing relationships with external partners and collaborating with specialist in the industry. The Associate Director should have superb experience in the following areas: -5-10 years' experience post PhD in Computational Biology, including at least 3-5 years' leading teams and projects. -Expertise designing projects and experiments to solve biomedical questions. -Strong experience of managing collaborative projects with multiple partners. -Good international network in the computational biology community would be a huge advantage. -Successful candidates will collaborate with our genetics and informatics groups to analyze our informatics systems for accuracy and content, and to further improve the analysis and interpretation of tumor-specific mutations. -Our mature informatics pipeline was developed and validated using whole genome sequence data on hundreds of thousands of patients. It begins with the raw sequence data and results in comprehensive variant calls, tumor-specific calls, and variant annotations along with raw BAM file data stored in our novel sequence database infrastructure. -These data and results are efficiently accessible through our validated web-based sequence analysis tools that integrate public domain disease variant and annotation datasets. The raw sequence data underlying potential pathogenic variants in germline or tumor sequences are immediately visualized for confirmation using our genome browser. This user-friendly system significantly reduces hands on time for the analysis and interpretation of sequence-based tests. The successful candidate will be located at our Cambridge site and will work with both our genetics group and our informatics group. Qualifications / Experience: Training of outside users and the testing and validation of new versions of the sequence analysis tools. Requirements: -PhD and a thorough understanding and experience in working with algorithms and software applications for high-throughput sequence data (NGS) -Significant programming experience is required (Unix shell programming and Python/Perl/Java/C++) -Familiarity with some of the mainstream software packages for secondary analysis, such as BWA, GATK, MuTect, VarScan2, etc.
Additional Info:
By unlocking the unique talents of a varied pool of individuals, we foster the kind of collaboration and innovation that yield truly great work. -We have clear, professional and respectful communication with everyone -We are all responsible for cutting-edge innovation -We are a TEAM -We balance critical thinking with execution -We care about employee’s professional and personal fulfillment We provide the world's only system with the demonstrated ability to enable analysis and management of massively-large datasets composed of hundreds of thousands of human genomes. Unlike relational databases, which cannot efficiently handle the trillions of data points associated with even several dozen patient genomes, our platform has been used to successfully manage data from more than 350,000 whole genomes representing more than 40 million identified variants. Our informatics systems have been finely tuned on this massive knowledge base to provide users with unmatched confidence in their results. We are delivering the resources developed at deCODE to the clinical domain so that physicians and geneticists can diagnose diseases of unknown origin faster and more accurately by quickly identifying and confirming the causative genes and mutations. We are a growing global genome informatics and diagnostics company offering the world’s most proven technology for next generation sequence-based genetic testing and analysis, and seek to hire bioinformaticians with expertise in cancer genetics including both germline and tumor genetics. We are a entrepreneurial EEO employer committed to a diverse and dynamic workplace.[Click Here to Access the Original Job Post]
This is a full-time position based in our in Cambridge, MA. Responsibilities: -Working with our team of scientists and informatics staff on continued development and implementation of the tumor vs germline analysis based on our informatics pipeline applied to whole exome and whole genome datasets. -This is a client-facing role and requires exceptional leadership skills, innovative/strategic thinking complimented by a strong, broad experience of Bioinformatics, preferably from within a large genomics, pharmaceutical or biotech environment. -The Associate Director is responsible for a team, each member an expert specializing in their own therapeutic discipline. -The AD provides supports and represents the department, establishing relationships with external partners and collaborating with specialist in the industry. The Associate Director should have superb experience in the following areas: -5-10 years' experience post PhD in Computational Biology, including at least 3-5 years' leading teams and projects. -Expertise designing projects and experiments to solve biomedical questions. -Strong experience of managing collaborative projects with multiple partners. -Good international network in the computational biology community would be a huge advantage. -Successful candidates will collaborate with our genetics and informatics groups to analyze our informatics systems for accuracy and content, and to further improve the analysis and interpretation of tumor-specific mutations. -Our mature informatics pipeline was developed and validated using whole genome sequence data on hundreds of thousands of patients. It begins with the raw sequence data and results in comprehensive variant calls, tumor-specific calls, and variant annotations along with raw BAM file data stored in our novel sequence database infrastructure. -These data and results are efficiently accessible through our validated web-based sequence analysis tools that integrate public domain disease variant and annotation datasets. The raw sequence data underlying potential pathogenic variants in germline or tumor sequences are immediately visualized for confirmation using our genome browser. This user-friendly system significantly reduces hands on time for the analysis and interpretation of sequence-based tests. The successful candidate will be located at our Cambridge site and will work with both our genetics group and our informatics group. Qualifications / Experience: Training of outside users and the testing and validation of new versions of the sequence analysis tools. Requirements: -PhD and a thorough understanding and experience in working with algorithms and software applications for high-throughput sequence data (NGS) -Significant programming experience is required (Unix shell programming and Python/Perl/Java/C++) -Familiarity with some of the mainstream software packages for secondary analysis, such as BWA, GATK, MuTect, VarScan2, etc.
Requeriments :
Skills :
- Lunix/Unix
- Next Generation Sequencing
- Programing in C++
- Programing in Python
- Programing Skills
- Programming in Java
- Programming in PERL
- Shell scripting
Areas :
Additional Info:
By unlocking the unique talents of a varied pool of individuals, we foster the kind of collaboration and innovation that yield truly great work. -We have clear, professional and respectful communication with everyone -We are all responsible for cutting-edge innovation -We are a TEAM -We balance critical thinking with execution -We care about employee’s professional and personal fulfillment We provide the world's only system with the demonstrated ability to enable analysis and management of massively-large datasets composed of hundreds of thousands of human genomes. Unlike relational databases, which cannot efficiently handle the trillions of data points associated with even several dozen patient genomes, our platform has been used to successfully manage data from more than 350,000 whole genomes representing more than 40 million identified variants. Our informatics systems have been finely tuned on this massive knowledge base to provide users with unmatched confidence in their results. We are delivering the resources developed at deCODE to the clinical domain so that physicians and geneticists can diagnose diseases of unknown origin faster and more accurately by quickly identifying and confirming the causative genes and mutations. We are a growing global genome informatics and diagnostics company offering the world’s most proven technology for next generation sequence-based genetic testing and analysis, and seek to hire bioinformaticians with expertise in cancer genetics including both germline and tumor genetics. We are a entrepreneurial EEO employer committed to a diverse and dynamic workplace.[Click Here to Access the Original Job Post]