Job ID:
Job date: 2018-05-08
End Date: 2018-07-07
Company : Agios Pharmaceuticals Country : United States Role : Research Scientist
Job date: 2018-05-08
End Date: 2018-07-07
Company : Agios Pharmaceuticals Country : United States Role : Research Scientist
Job Description:
We are looking for a talented Computational Biologist/Bioinformatics Scientist to join the Cell Metabolism team. Key Responsibilities:
Additional Info:
Agios Pharmaceuticals is focused on discovering and developing novel drugs to treat cancer and rare genetic metabolic diseases, through scientific leadership in the field of cellular metabolism. In addition to an active research and discovery pipeline across both therapeutics areas, Agios has multiple first-in-class lead product candidates in cancer metabolism and rare genetic, metabolic diseases in clinical and/or preclinical development. All Agios programs focus on genetically identified patient populations, leveraging our knowledge of metabolism, biology and genomics. The Cell Metabolism department focuses on quantitatively understanding cellular metabolism, relying on state-of-the-art mass spectrometry methods for proteomics, metabolomics, and isotopic labeling studies. Our work includes characterization of the metabolism of tumors with specific genetic features, including the metabolism of both cancer cells and immune cells, as well as metabolic effects of genetic disorders.[Click Here to Access the Original Job Post]
We are looking for a talented Computational Biologist/Bioinformatics Scientist to join the Cell Metabolism team. Key Responsibilities:
- Analyze both small and large-scale biological data, including metabolomics, proteomics, and transcriptomics. In collaboration with biologists, drive understanding of how cellular metabolism is perturbed by environmental or genetic fluctuation.
- Work to improve this process – in collaboration with biologists, informaticians, and analytical chemists, develop and improve methods to extract maximal biological insight from both internal and external data.
- One key focus will be design and implementation of methods for high-throughput analysis of mass spectrometry metabolomics data. Refine methodologies for data storage, processing and visualization, and optimize performance and usability.
- BS/MS in Biology, Bioinformatics or related field with 4+ years of experience.
- Must have experience working with biological or chemical data in a scientific research environment.
- Expertise in numerical data analysis and scientific programming. Expert-level understanding of at least one scientific computing environment is expected.
- Self-motivated and able to work independently or in a small team with minimal supervision.
- Excellent communication and organizational skills.
- PhD preferred, with 0+ years of postdoc experience.
- Experience with mass spectrometry, particularly with metabolomics
- Advanced understanding of cellular metabolism at the cellular/molecular/biochemical level.
- Experience in a drug discovery environment.
- Experience with modern machine learning techniques, advanced statistics and linear algebra Python (numpy/scipy/pandas) experience is preferred. Experience with R, MATLAB, C, and C++ is also a plus.
- Experience with designing or working with large relational databases, understanding of cloud storage methodologies and best practices.
- Experience with commercial data visualization platforms, such as Spotfire/Tableau, or experience with web-based data visualization frameworks such as D3.
Requeriments :
Skills :
- Database design
- Machine Learning
- Programing in C
- Programing in C++
- Programing in Python
- Programing Skills
- Programming in Matlab
- Programming in R
- Statistics
Areas :
Additional Info:
Agios Pharmaceuticals is focused on discovering and developing novel drugs to treat cancer and rare genetic metabolic diseases, through scientific leadership in the field of cellular metabolism. In addition to an active research and discovery pipeline across both therapeutics areas, Agios has multiple first-in-class lead product candidates in cancer metabolism and rare genetic, metabolic diseases in clinical and/or preclinical development. All Agios programs focus on genetically identified patient populations, leveraging our knowledge of metabolism, biology and genomics. The Cell Metabolism department focuses on quantitatively understanding cellular metabolism, relying on state-of-the-art mass spectrometry methods for proteomics, metabolomics, and isotopic labeling studies. Our work includes characterization of the metabolism of tumors with specific genetic features, including the metabolism of both cancer cells and immune cells, as well as metabolic effects of genetic disorders.[Click Here to Access the Original Job Post]