Job ID: 470611361
Job date: 2017-11-28
End Date:
Company : Paramount Recruitment Country : Role : Other
Job date: 2017-11-28
End Date:
Company : Paramount Recruitment Country : Role : Other
Job Description:
A great opportunity is available for a Bioinformatician to join a global Bio-Pharma based in the UK. The client focuses on central nervous system and immunology disorders and aim to tackle unmet medical needs around the world. The client aims to understand the different molecular origins of disease in different patient sub-populations to cater personalised medicine. You will work closely with the translational bioinformatics team to stratify Alzheimer’s and Parkinson’s Disease patients and build predictive models of disease progression. You will develop and implement novel methods for extracting biologically intuitive genomic features from patient molecular datasets, specifically gene-level and pathway-level measures of mutational burden. These feature sets will be used to stratify patients using unsupervised clustering and develop predictive models of risk and disease progression for Alzheimer’s Disease Neuroimaging Initiative (ADNI) and Parkinson’s Progression Marker Initiative (PPMI) data sets. Requirements:
Additional Info:
Please do not hesitate to contact Harvey Uppal at huppal@pararecruit.com or call (+44) 121 616 3407 to discuss this opportunity further. Keywords: Bioinformatics, Pharma, Translational, Parkinson’s, Alzheimer’s Epigenomics, Genetics, Genomics, NGS, Python, Statistics, HPC, Linux, SAMtools, Bash, WGS, Machine Learning, Cloud. Paramount Recruitment Limited provides services as an agency and an employment business. We regularly have similar roles in this area. Please see our website for details or send your CV in to us to find out the latest opportunities. Job Reference: HUCBBS_1511779667 Broadcast As: 18372 Salary To: Negotiable Job Type: Full Time Job Term: Permanent Job Country: Slough , Berkshire , S. E. England , England Job Industry: Biotech , IT Job Specialism: Engineering , Science R and D Recruitment Consultant: Harvey Uppal[Click Here to Access the Original Job Post]
A great opportunity is available for a Bioinformatician to join a global Bio-Pharma based in the UK. The client focuses on central nervous system and immunology disorders and aim to tackle unmet medical needs around the world. The client aims to understand the different molecular origins of disease in different patient sub-populations to cater personalised medicine. You will work closely with the translational bioinformatics team to stratify Alzheimer’s and Parkinson’s Disease patients and build predictive models of disease progression. You will develop and implement novel methods for extracting biologically intuitive genomic features from patient molecular datasets, specifically gene-level and pathway-level measures of mutational burden. These feature sets will be used to stratify patients using unsupervised clustering and develop predictive models of risk and disease progression for Alzheimer’s Disease Neuroimaging Initiative (ADNI) and Parkinson’s Progression Marker Initiative (PPMI) data sets. Requirements:
- Flexibility, genuine intellectual curiosity, ideation and eagerness to contribute are key elements of the position.
- The individual should have a passion for statistical concepts, data mining, and visualization of biological data types.
- Extensive experience of implementing and executing NGS pre-processing and analysis pipelines e.g. whole genome sequencing, epigenetics and proteomics.
- Familiarity with methods for genetic variant annotation (e.g. SnpEff, VEP) and functional genomics resources (ENCODE and Roadmap Epigenomics).
- Understanding of network biology concepts (community detection) and practical familiarity with common resources (PPI and pathway databases)
- Deep knowledge of scripting in R or Python. Experience of method development in complied languages would be an advantage.
- Confidence programming in a Linux / HPC environment, including shell scripting (bash, tcsh), text processing utilities (sed, awk), and tools for NGS data manipulation (bcftools and samtools)
- Experience of cloud-based NGS pipelining environments such as DNA Nexus and Seven bridges would be an advantage.
Skills :
- Data Mining
- HPC
- Lunix/Unix
- Next Generation Sequencing
- Programing in Python
- Programing Skills
- Programming in R
- Shell scripting
- Statistics
Areas :
Additional Info:
Please do not hesitate to contact Harvey Uppal at huppal@pararecruit.com or call (+44) 121 616 3407 to discuss this opportunity further. Keywords: Bioinformatics, Pharma, Translational, Parkinson’s, Alzheimer’s Epigenomics, Genetics, Genomics, NGS, Python, Statistics, HPC, Linux, SAMtools, Bash, WGS, Machine Learning, Cloud. Paramount Recruitment Limited provides services as an agency and an employment business. We regularly have similar roles in this area. Please see our website for details or send your CV in to us to find out the latest opportunities. Job Reference: HUCBBS_1511779667 Broadcast As: 18372 Salary To: Negotiable Job Type: Full Time Job Term: Permanent Job Country: Slough , Berkshire , S. E. England , England Job Industry: Biotech , IT Job Specialism: Engineering , Science R and D Recruitment Consultant: Harvey Uppal[Click Here to Access the Original Job Post]