Job ID: 10100
Job date: 2017-01-13
End Date:
Company : Mount Sinai Health System Country : Role : Research Scientist
Job date: 2017-01-13
End Date:
Company : Mount Sinai Health System Country : Role : Research Scientist
Job Description:
The Icahn Institute for Genomics and Multiscale Biology at Mount Sinai is seeking talented, motivated, passionate individuals to drive leading edge research and development as part of the Cancer Genomics and Clinical Genome Informatics groups. The successful applicant will become part of an interdisciplinary team of bioinformaticians, geneticists, molecular and cell biologists, “big data” scientists, and clinicians engaged in translational research and clinical projects across multiple disease areas. The work will primarily be focused on developing the science, methods, and infrastructure for multiscale profiling and interpretation of cancer genomes and transcriptomes, translating these methods into clinical practice, and assessing their utility in a clinical setting. The successful applicant will carry out this work under the close guidance and supervision of the director of the Cancer Genomics group. Applicants passing the initial phone screen will be asked to take an at-home exam testing their NGS and variant calling knowledge, data analysis proficiency, and programming ability. Responsibilities: • Lead or support bioinformatics analyses for translational cancer genomics studies in collaboration with clinicians and experimental cancer biologists. • Analyze and integrate heterogeneous NGS data (somatic and germline SNVs, indel variants, copy-number alterations, structural variants, gene fusions, RNA abundance) from diverse next-generation sequencing assays (Illumina, Ion Torrent, Pacific Biosciences; targeted panels, whole-exome sequencing, whole-genome sequencing, RNA-Seq; bulk and single-cell) and microarrays. • Integrate above with clinical data (treatment history, response, biomarkers, disease progression) and phenotypic/demographic data to carry out analysis and generate testable hypotheses about driver mechanisms in tumorigenesis or disease progression, as well as factors responsible for disease response to targeted therapeutics. • Contribute to development of infrastructure for integrating data from multiple NGS technologies, as well as variant annotation and interpretation. • Publish and present novel findings in academic journals and conferences. What You'll bring: Experience and Education desired: • Well-versed in the art of effective communication on interdisciplinary teams, especially graphical communication about large or high-complexity datasets. • Strong coding proficiency in Python, SQL, and R programming languages in a Linux environment. • Hands-on experience working with NGS tools and data/file formats. • Using or developing genome browsers or other tools for visualization of genomic datasets. • Understanding of molecular biology and pathways involved in cancer. • Developing code using distributed version control tools (especially Mercurial or Git) and software issue tracking/management systems (especially JIRA). • M.S. or PhD in Bioinformatics, Biomedical Informatics, Computational Biology, or Genomics. Alternately, an M.S. or PhD in a discipline requiring strong computational and analytical skills supplemented with some biology background. • Minimum 2 years post-graduate experience. • Proven track record of successfully handling multiple projects in a dynamic environment with shifting priorities. Do you share our dedication to extraordinary service and have what it takes to wear the badge? Apply now!
Additional Info:
The Mount Sinai Health System's commitment to excellence extends beyond delivering world-class health care. The System's ongoing success is dependent upon our highly motivated, nonclinical professionals working to improve business operations. Our leadership team is driven to provide exceptional service by cultivating a workforce that is dedicated to upholding Mount Sinai's mission of delivering innovative, breakthrough medicine with compassion and integrity. Who We Are: Over 35,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve. Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke's, and New York Eye and Ear Infirmary of Mount Sinai. The Mount Sinai Health System is committed to the tenets of diversity and workforce that are strengthened by the inclusion of and respect for our differences. We offer our employees a highly competitive compensation and benefits package, a 403(b) retirement plan, and much more. The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation. EOE Minorities/Women/Disabled/Veterans[Click Here to Access the Original Job Post]
The Icahn Institute for Genomics and Multiscale Biology at Mount Sinai is seeking talented, motivated, passionate individuals to drive leading edge research and development as part of the Cancer Genomics and Clinical Genome Informatics groups. The successful applicant will become part of an interdisciplinary team of bioinformaticians, geneticists, molecular and cell biologists, “big data” scientists, and clinicians engaged in translational research and clinical projects across multiple disease areas. The work will primarily be focused on developing the science, methods, and infrastructure for multiscale profiling and interpretation of cancer genomes and transcriptomes, translating these methods into clinical practice, and assessing their utility in a clinical setting. The successful applicant will carry out this work under the close guidance and supervision of the director of the Cancer Genomics group. Applicants passing the initial phone screen will be asked to take an at-home exam testing their NGS and variant calling knowledge, data analysis proficiency, and programming ability. Responsibilities: • Lead or support bioinformatics analyses for translational cancer genomics studies in collaboration with clinicians and experimental cancer biologists. • Analyze and integrate heterogeneous NGS data (somatic and germline SNVs, indel variants, copy-number alterations, structural variants, gene fusions, RNA abundance) from diverse next-generation sequencing assays (Illumina, Ion Torrent, Pacific Biosciences; targeted panels, whole-exome sequencing, whole-genome sequencing, RNA-Seq; bulk and single-cell) and microarrays. • Integrate above with clinical data (treatment history, response, biomarkers, disease progression) and phenotypic/demographic data to carry out analysis and generate testable hypotheses about driver mechanisms in tumorigenesis or disease progression, as well as factors responsible for disease response to targeted therapeutics. • Contribute to development of infrastructure for integrating data from multiple NGS technologies, as well as variant annotation and interpretation. • Publish and present novel findings in academic journals and conferences. What You'll bring: Experience and Education desired: • Well-versed in the art of effective communication on interdisciplinary teams, especially graphical communication about large or high-complexity datasets. • Strong coding proficiency in Python, SQL, and R programming languages in a Linux environment. • Hands-on experience working with NGS tools and data/file formats. • Using or developing genome browsers or other tools for visualization of genomic datasets. • Understanding of molecular biology and pathways involved in cancer. • Developing code using distributed version control tools (especially Mercurial or Git) and software issue tracking/management systems (especially JIRA). • M.S. or PhD in Bioinformatics, Biomedical Informatics, Computational Biology, or Genomics. Alternately, an M.S. or PhD in a discipline requiring strong computational and analytical skills supplemented with some biology background. • Minimum 2 years post-graduate experience. • Proven track record of successfully handling multiple projects in a dynamic environment with shifting priorities. Do you share our dedication to extraordinary service and have what it takes to wear the badge? Apply now!
Requeriments :
Skills :
- Cancer biology
- Lunix/Unix
- Microarray
- molecular biology
- Next Generation Sequencing
- Programing in Python
- Programming in R
- RNA-seq
- SQL
Areas :
Additional Info:
The Mount Sinai Health System's commitment to excellence extends beyond delivering world-class health care. The System's ongoing success is dependent upon our highly motivated, nonclinical professionals working to improve business operations. Our leadership team is driven to provide exceptional service by cultivating a workforce that is dedicated to upholding Mount Sinai's mission of delivering innovative, breakthrough medicine with compassion and integrity. Who We Are: Over 35,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve. Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke's, and New York Eye and Ear Infirmary of Mount Sinai. The Mount Sinai Health System is committed to the tenets of diversity and workforce that are strengthened by the inclusion of and respect for our differences. We offer our employees a highly competitive compensation and benefits package, a 403(b) retirement plan, and much more. The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation. EOE Minorities/Women/Disabled/Veterans[Click Here to Access the Original Job Post]