Job ID: 82991
Job date: 2018-02-26
End Date:
Company : Wellcome Trust Sanger Institute Country : Role : Research Scientist
Job date: 2018-02-26
End Date:
Company : Wellcome Trust Sanger Institute Country : Role : Research Scientist
Job Description:
Fixed Term for 3 years, Job Family: Informatician/ Data Scientist, Grade 2 or 3 (depending on experience) The Wellcome Sanger Institute are seeking to recruit a Bioinformatician / Senior Bioinformatician who can facilitate the scientific work of the Jones group by leading the computational data analysis support for the team and their collaborators. The group, led by Phil Jones, studies pre-cancer, how mutant cells evolve into cancers in humans and model systems (http://www.sanger.ac.uk/science/groups/jones-group). We are passionate about how mutant clones compete with each other and interact with the cancer promoting environment during epithelial cancer evolution in order to guide new cancer prevention therapy. Our cross disciplinary approach exploits quantitative methods to link mutation with changes in cell dynamics (see links 1-3 below). Recent work includes developing a new deep sequencing technique to reveal a high density of clonal mutations in normal human skin, basis of skin stem cell fate and developing new models of oesophageal cancer. The post holder will be able to exploit extensive bioinformatics expertise within the Institute. Many of our experiments involve the generation of large quantities of DNA sequencing which require strong computational skills to build high quality data and carry out statistical analysis to interpret the results. Collaborating within the team with experimentalists and quantitative biologists to integrate genomic analysis with other types of data to resolve the cellular and tissue effects of mutations within tissues is a significant part of what we do. You will be an excellent communicator and be able to understand the scientific background and technical detail of the team's projects, and be to be proficient at devising and implementing software solutions and statistical analysis. This role would suit a graduate with coding ability who wishes to contribute to understanding how cancer develops. Training in the background biology and computational skills will be provided. You will work in conjunction with other computational biologists in the group and with other teams at Institute.
Additional Info:
Location: Cambridge, Hinxton Salary: £25,125 - £30,402 (Bioinformatician); £35,924 - £43,468 (Senior Bioinformatician) per annum, plus excellent benefits Hours: Full Time Contract Type: Fixed-Term/Contract Placed on: 19th February 2018 Closes: 18th March 2018 Job Ref: 82991 The Sanger Institute is a charitably funded research centre passionate about understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and the Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society. To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus. Wellcome Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status. Please include a covering letter and CV with your application. Closing date for applications: 18th March 2018 If you have any informal queries please contact Phil Jones pj3@sanger.ac.uk[Click Here to Access the Original Job Post]
Fixed Term for 3 years, Job Family: Informatician/ Data Scientist, Grade 2 or 3 (depending on experience) The Wellcome Sanger Institute are seeking to recruit a Bioinformatician / Senior Bioinformatician who can facilitate the scientific work of the Jones group by leading the computational data analysis support for the team and their collaborators. The group, led by Phil Jones, studies pre-cancer, how mutant cells evolve into cancers in humans and model systems (http://www.sanger.ac.uk/science/groups/jones-group). We are passionate about how mutant clones compete with each other and interact with the cancer promoting environment during epithelial cancer evolution in order to guide new cancer prevention therapy. Our cross disciplinary approach exploits quantitative methods to link mutation with changes in cell dynamics (see links 1-3 below). Recent work includes developing a new deep sequencing technique to reveal a high density of clonal mutations in normal human skin, basis of skin stem cell fate and developing new models of oesophageal cancer. The post holder will be able to exploit extensive bioinformatics expertise within the Institute. Many of our experiments involve the generation of large quantities of DNA sequencing which require strong computational skills to build high quality data and carry out statistical analysis to interpret the results. Collaborating within the team with experimentalists and quantitative biologists to integrate genomic analysis with other types of data to resolve the cellular and tissue effects of mutations within tissues is a significant part of what we do. You will be an excellent communicator and be able to understand the scientific background and technical detail of the team's projects, and be to be proficient at devising and implementing software solutions and statistical analysis. This role would suit a graduate with coding ability who wishes to contribute to understanding how cancer develops. Training in the background biology and computational skills will be provided. You will work in conjunction with other computational biologists in the group and with other teams at Institute.
- Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P et al. Science 2015;348; 880-6. Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. PUBMED: 25999502; DOI: 10.1126/science.aaa6806
- Roshan A, Murai K, Fowler J, Simons BD, Nikolaidou-Neokosmidou V and Jones PH. Human keratinocytes have two interconvertible modes of proliferation. Nature cell biology 2016;18;145-56. PUBMED: 26641719; DOI: 10.1038/ncb3282
- Frede J, Greulich P, Nagy T, Simons BD and Jones PH. A single dividing cell population with imbalanced fate drives oesophageal tumour growth. Nature cell biology 2016;18, 967-78. PUBMED: 27548914; DOI: 10.1038/ncb3400
- A degree or related to biology/genetics/computer science/mathematics
- Research experience and/or PhD degree
- Experience of bioinformatics and familiarity with genome data
- Evidence of proficiency a modern computer language
- Experience of researching/using/supporting external software packages
- Ability to rapidly attain new technical skills and understanding of new technical concepts
- A high level of interpersonal skills to be able to elicit complex requirements from, and convey complex information to, group members with different levels of technical knowledge
- Ability to quickly adapt to new problems and ideas
- Ability to work unsupervised
- Excellent analytical skills
- R and/or Python programming experience
- Bioinformatics experience in analysis of Next Generation Sequencing.
- Experience of working with biological analysis pipelines on multi-node compute clusters
- Experience in pathway analysis software
- Proficient in statistical analysis of genome-wide datasets
- R and/or Python programming experience
- Bioinformatics experience in analysis of Next Generation Sequencing.
- Experience of working with biological analysis pipelines on multi-node compute clusters
- Experience in pathway analysis software
- Proficient in statistical analysis of genome-wide datasets
- Research experience and/or PhD degree
Requeriments :
Skills :
- Bioinformatics
- Next Generation Sequencing
- Programing in Python
- Programing Skills
- Programming in R
- Statistics
Areas :
Additional Info:
Location: Cambridge, Hinxton Salary: £25,125 - £30,402 (Bioinformatician); £35,924 - £43,468 (Senior Bioinformatician) per annum, plus excellent benefits Hours: Full Time Contract Type: Fixed-Term/Contract Placed on: 19th February 2018 Closes: 18th March 2018 Job Ref: 82991 The Sanger Institute is a charitably funded research centre passionate about understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and the Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society. To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus. Wellcome Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status. Please include a covering letter and CV with your application. Closing date for applications: 18th March 2018 If you have any informal queries please contact Phil Jones pj3@sanger.ac.uk[Click Here to Access the Original Job Post]