Bioinformatician/Population Geneticist

Job Description:

Bioinformatician / Population Geneticist

Job Summary

 A bioinformatician/ population geneticist is required to undertake genomics research on perennial fruit species and their pathogens and pests. Much of the research undertaken will work towards investigating the molecular mechanisms involved in host resistance to pathogens. The successful applicant will work across multiple BBSRC funded projects to elucidate the genetic basis of disease resistance in the first instance to the oomycete pathogens Phytophthora cactorum and Phytophthora fragariae in the octopoloid strawberry Fragaria x ananassa. An interest in the evolutionary dynamics of host-pathogen interactions would be highly desirable.

 Key areas of the job

Population-level analysis of candidate resistance gene and pathogen effector genes: Familiarity with   basic population genetics approaches to detect selection from nucleotide sequences  either using between species data (e.g. PAML) and/or within species (e.g. McDonald- Kreitman  tests, Tajima’s D, haplotype tests etc)  Analysis of RNA-seq transcriptome time-course data in order to identify candidate host and effector genes which are implicated in host-pathogen interactions. Analysis of gene regulatory networks is an important component of this work, linking expression to genes with QTL and analysing subgenome-specific patterns of expression variation Quantitative genetics analysis of disease resistance using mixed modelling approaches- a working knowledge of mixed-model approaches to the analysis of quantitative trait data and genotypic data to identify genetic variants contributing to variation in complex traits Developing national and international collaborations with other organisations involved in genomics and bioinformatics research on horticultural crops  Publishing results in high impact refereed journals and giving presentations at national and international conferences  Working in accordance with EMR’s Health and Safety Objectives, comply with EMQA (East Malling Quality Assurance) requirements and contribute to EMR’s corporate responsibilities

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Requeriments :

• Doctorate Degree

Skills :

• Bioinformatics
• Genetics
• Population Genetics
• Programing in Python
• Programing Skills
• Programming in PERL
• RNA-seq

Areas :

• Bioinformatics

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Additional Info:

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