Job Description:
The Department of Systems Biology at Columbia University Medical Center is seeking a highly motivated Bioinformatics Analyst for Dr. Andrea Califano's laboratory with strong expertise in bioinformatics to lead data analysis in large-scale, omics-based studies of human disease. The ideal candidate would have additional experience in network/systems biology, including analysis of regulatory networks, integrative analysis to combine evidence from multiple data modalities, and expertise with Bioconductor packages. Characteristic Duties and Responsibilities: The incumbent will be required to carry out the following duties and responsibilities: - Apply state-of-the-art computational methods to analyze large-scale RNA, whole genome, and whole exome sequencing data to support integrative data analysis in a variety of human disease and normal physiology settings. - Become familiar, debug, and maintain robust, fully automated computational pipelines implemented by lab members to elucidate molecular mechanisms and associated small molecule compound dependencies in human disease and human physiology based on the integrative, network-based analysis of multiple 'omics data types. - Collect and curate publicly available 'omics data sets to support integrative analysis in systems biology based studies. - Design novel integrative and automation frameworks to create novel pipelines for the analysis of 'omics data. Minimum Qualifications for Grade: Applicant MUST meet these minimum qualifications to be considered an applicant: -Bachelor degree in Computational Biology, Bioinformatics, Genetics, or equivalent in education and experience, plus three years of related experience. -Demonstrated experience in high-throughput sequencing data analysis or method development. -Programming: Fluency with at least one general-purpose programming language (such as C/C++, Ruby, Perl, or Python), and one language for scientific computing (such as R or MATLAB). Experience with source code version control systems. --Excellent communication skills and teamwork. Strong creative thinking and problem solving skills. Preferred Qualifications: -The ideal candidate will have a MS or PhD degree in Computational Biology, Bioinformatics, Genetics, or equivalent. -Prior experience in software engineering and in the design of software for the bioinformatics/systems-biology analysis of biological systems is desirable. -The ideal candidate will have significant experience in R and in the use of R packages for bioinformatics analyses, including the Bioconductor framework.
Additional Info:
Department 7574- JSB C2B2 Location Medical Center Job Type Officer Full-Time Regular Hours Per Week: 35 Job Family: Research (Laboratory and Non-Laboratory) Salary Grade: Officer 104 The Califano lab studies the molecular determinants of human pathophysiology, with specific focus on cancer and stem cell biology. A key focus of the lab is in the area of systems pharmacology, with the objective of characterizing drug mechanism of action de novo and to match it to the specific cellular mechanisms of human disease. Major ongoing projects include: reverse engineering and analysis of transcriptional, signal transduction, and protein-protein interaction networks; the identification of master regulators of human disease and of other pathophysiologic phenotypes from molecular profiles of individual tissues and single cells; the prioritization of small molecule compound that are optimally suited to target these mechanisms; and the design of clinical trial to evaluate these findings; and the design of clinical trials to evaluate the effectiveness of prioritized compounds on an individual patient basis. Requisition Open Date: 01-17-2018 Requisition Close Date: Open Until Filled EEO Statement: Columbia University is an Equal Opportunity/Affirmative Action employer --Race/Gender/Disability/Veteran. Local Hiring: Columbia University is committed to the hiring of qualified local residents. [Click Here to Access the Original Job Post]
The Department of Systems Biology at Columbia University Medical Center is seeking a highly motivated Bioinformatics Analyst for Dr. Andrea Califano's laboratory with strong expertise in bioinformatics to lead data analysis in large-scale, omics-based studies of human disease. The ideal candidate would have additional experience in network/systems biology, including analysis of regulatory networks, integrative analysis to combine evidence from multiple data modalities, and expertise with Bioconductor packages. Characteristic Duties and Responsibilities: The incumbent will be required to carry out the following duties and responsibilities: - Apply state-of-the-art computational methods to analyze large-scale RNA, whole genome, and whole exome sequencing data to support integrative data analysis in a variety of human disease and normal physiology settings. - Become familiar, debug, and maintain robust, fully automated computational pipelines implemented by lab members to elucidate molecular mechanisms and associated small molecule compound dependencies in human disease and human physiology based on the integrative, network-based analysis of multiple 'omics data types. - Collect and curate publicly available 'omics data sets to support integrative analysis in systems biology based studies. - Design novel integrative and automation frameworks to create novel pipelines for the analysis of 'omics data. Minimum Qualifications for Grade: Applicant MUST meet these minimum qualifications to be considered an applicant: -Bachelor degree in Computational Biology, Bioinformatics, Genetics, or equivalent in education and experience, plus three years of related experience. -Demonstrated experience in high-throughput sequencing data analysis or method development. -Programming: Fluency with at least one general-purpose programming language (such as C/C++, Ruby, Perl, or Python), and one language for scientific computing (such as R or MATLAB). Experience with source code version control systems. --Excellent communication skills and teamwork. Strong creative thinking and problem solving skills. Preferred Qualifications: -The ideal candidate will have a MS or PhD degree in Computational Biology, Bioinformatics, Genetics, or equivalent. -Prior experience in software engineering and in the design of software for the bioinformatics/systems-biology analysis of biological systems is desirable. -The ideal candidate will have significant experience in R and in the use of R packages for bioinformatics analyses, including the Bioconductor framework.
Requeriments :
Skills :
- Bioinformatics
- Programing in C
- Programing in C++
- Programing in Python
- Programing Skills
- Programming in Matlab
- Programming in PERL
- Programming in R
- Software Design
- Systems Biology
- Version Control
Areas :
Additional Info:
Department 7574- JSB C2B2 Location Medical Center Job Type Officer Full-Time Regular Hours Per Week: 35 Job Family: Research (Laboratory and Non-Laboratory) Salary Grade: Officer 104 The Califano lab studies the molecular determinants of human pathophysiology, with specific focus on cancer and stem cell biology. A key focus of the lab is in the area of systems pharmacology, with the objective of characterizing drug mechanism of action de novo and to match it to the specific cellular mechanisms of human disease. Major ongoing projects include: reverse engineering and analysis of transcriptional, signal transduction, and protein-protein interaction networks; the identification of master regulators of human disease and of other pathophysiologic phenotypes from molecular profiles of individual tissues and single cells; the prioritization of small molecule compound that are optimally suited to target these mechanisms; and the design of clinical trial to evaluate these findings; and the design of clinical trials to evaluate the effectiveness of prioritized compounds on an individual patient basis. Requisition Open Date: 01-17-2018 Requisition Close Date: Open Until Filled EEO Statement: Columbia University is an Equal Opportunity/Affirmative Action employer --Race/Gender/Disability/Veteran. Local Hiring: Columbia University is committed to the hiring of qualified local residents. [Click Here to Access the Original Job Post]