Job Description:
The Merajver Lab is seeking a lead bioinformatician to play a senior role in supporting the lab’s research program. The lab is devoted to understanding the molecular genetics and associated functions of very aggressive breast and other cancers. The primary areas of focus are systems biology, mathematical oncology, biophysics, cell biology, genetics, and precision medicine drug development. The bioinformatician will be responsible for coordinating informatics efforts across the lab, supporting lab faculty, staff scientists, postdocs, and students in their research efforts and developing novel methodologies when necessary. Responsibilities:
Additional Info:
How to Apply: A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position. Background Screening: Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Mission Statement: Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society. Application Deadline Job openings are posted for a minimum of seven calendar days. This job may be removed from posting boards and filled anytime after the minimum posting period has ended. U-M EEO/AA Statement The University of Michigan is an equal opportunity/affirmative action employer.[Click Here to Access the Original Job Post]
The Merajver Lab is seeking a lead bioinformatician to play a senior role in supporting the lab’s research program. The lab is devoted to understanding the molecular genetics and associated functions of very aggressive breast and other cancers. The primary areas of focus are systems biology, mathematical oncology, biophysics, cell biology, genetics, and precision medicine drug development. The bioinformatician will be responsible for coordinating informatics efforts across the lab, supporting lab faculty, staff scientists, postdocs, and students in their research efforts and developing novel methodologies when necessary. Responsibilities:
- Meet with lab and collaborating researchers including faculty, staff scientists, postdocs, and students to understand their scientific questions of interest. Assist in developing and/or revising researchers’ experimental designs and analytical approaches as necessary.
- Lead the development and execution of both standard and custom analyses, coordinating systematic exploration of complex, high-dimensional data to identify key, testable metrics. Identify and resolve data quality issues as necessary.
- Develop bioinformatics pipelines to automate analysis of both internally generated and publically available datasets. Extend existing pipelines with new functionality, create/adopt new pipelines to address emerging technologies in the field, and integrate data across types and sources.
- Document and present bioinformatics methods and analysis results. Co-author scientific presentations and publications based on analyses performed.
- Participate in the development of grant proposals.
- Continue professional development by reviewing literature and evaluating tools to identify and validate emerging methods.
- Supervise bioinformatics postdocs and graduate students who are performing bioinformatic analysis
- Passionate about science and research
- PhD in Bioinformatics, Biostatistics, Computer Science, or Mathematics
- A minimum of 2 years experience in cancer research
- A minimum of 10 years experience in bioinformatics development/analysis, preferably working with a broad range of researchers across a range of phenotypes and data types.
- Advanced understanding of cancer as well as multiple scientific areas characteristic of bioinformatics (e.g. molecular/cell biology, genetics/genomics, proteomics, computer science, data modeling/statistics).
- Strong software development skills in a unix environment (e.g. Python, Java, SQL, GIT).
- Familiarity with Next Generation Sequencing (NGS) data analysis methods and their application to cancer research, including tumor WGS, WES, RNA-Seq, and targeted gene panel sequencing methodologies.
- Knowledge of statistical analysis and machine learning techniques using modern computational tools (e.g. R, BioConductor, pandas, scikit-learn).
- Experience with High Performance Computing (Torque, PBS, Slurm, etc.)
- Familiarity with relevant public data sources and methods (Broad GATK, TCGA/ICGC, ClinVar, COSMIC, ExAC, etc.)
- Familiarity with functional annotation, enrichment, and pathway analysis methods.
- Candidate must have excellent communication and interpersonal skills, with the demonstrated ability to work effectively with diverse groups of people at various of levels of expertise.
- Research experience in tumor heterogeneity and subclonality
- Experience in single-cell sequencing methodologies
- Experience in drug development and biomarker detection
- A strong publication record
- Experience in the mathematical modeling of cancer and metastasis
- Familiarity with Agile software practices
Requeriments :
Skills :
- Bioinformatics
- Cancer biology
- Cell Biology
- Genetics
- genomic
- HPC
- Lunix/Unix
- Machine Learning
- Mathematics
- Modeling
- molecular biology
- Next Generation Sequencing
- Programing in Python
- Programming in Java
- Programming in R
- RNA-seq
- Software Design
- SQL
- Statistics
Areas :
Additional Info:
How to Apply: A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position. Background Screening: Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Mission Statement: Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society. Application Deadline Job openings are posted for a minimum of seven calendar days. This job may be removed from posting boards and filled anytime after the minimum posting period has ended. U-M EEO/AA Statement The University of Michigan is an equal opportunity/affirmative action employer.[Click Here to Access the Original Job Post]