Bioinformatics Scientist, Cancer Immunology

Job Description:
Who We Are At Roche, 88,500 people across 150 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity. A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 35 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. The headquarters for Roche pharmaceutical operations in the United States, Genentech has multiple therapies on the market for cancer and other serious illnesses. Please take this opportunity to learn about Genentech, where we believe that our employees are our most important asset and are dedicated to remaining a great place to work. The Position Recently, exciting developments at Genentech and elsewhere have raised the possibility of leveraging the human immune system for effective and durable control of cancer. Genentech seeks a talented and highly motivated bioinformatic scientist to pursue research projects in collaboration with our Cancer Immunology Department, and to contribute to the identification and development of the next generation of immune-based cancer therapies. The primary focus will be on generation and interpretation of high-throughput genomic and other molecular data that increase our understanding of, for example:

• The degree and nature of immune infiltration in the tumor microenvironment;
• Mechanisms by which tumors avoid immune surveillance;
• The impact of mutation or gene expression dysregulation on tumor neo-antigen presentation; and
• Local or circulating biomarkers which predict response to immunomodulatory drugs or therapies.

Emphasis is on basic research, but with a direct connection to the clinic and to Genentech’s drug and biomarker development initiatives. A successful candidate will work with interdisciplinary teams, carry out data analysis and integration across various domains, and apply best-in-class algorithms — or develop new algorithms — that directly address the motivating biological and clinical questions. Regular publication of both scientific and methodological results is strongly encouraged. Finally, the successful candidate will be able to effectively present complex results in a clear and concise manner that is accessible to a diverse audience of quantitative, experimental, and clinical scientists. There is potential for a management/supervisory role for candidates who are more advanced in their careers. Who You Are

• PhD in bioinformatics, biostatistics, computational biology or similar, with a strong publication record. Alternately, a PhD in molecular biology, immunology, etc. combined with a very strong record of high-throughput data analysis, supported by publication in this area.
• A solid understanding of the relevant concepts in cancer biology and genetics, or in immunology. Enthusiasm for learning more.
• Broad experience with data generated by one or more high-throughput molecular assays: microarrays, next-generation sequencing, multiplexed qPCR, flow cytometry, mass spectrometry proteomics, etc.
• An understanding of the statistical principles behind current best practices in high-throughput molecular data analysis.
• Strong experience in the use of a high-level programming language such as R, MATLAB, Python or Perl for complex data analysis.
• Exceptionally strong communication, data presentation and visualization skills.
• Ability to work both independently and collaboratively, and to handle several concurrent, fast-paced projects.

The next step is yours. To apply today, click on the "Apply online" button below. Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity protections, view theEEO is the Law poster. If you have a disability and need an accommodation in connection with the on-line application process, please email us at US.Accommodation@roche.com .

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Requeriments :

• M.Sc. or higher Degree in Bioinformatics

Skills :

• Bioinformatics
• Biology
• Cancer biology
• Programing in Python
• Programming in Matlab
• Programming in PERL
• Programming in R

Areas :

• Bioinformatics
• Computational Biology

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Additional Info:

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