Job ID: 16246
Job date: 2018-03-17
End Date:
Company : Children s Hospital of Philadelphia Country : Role : Research Scientist
Job date: 2018-03-17
End Date:
Company : Children s Hospital of Philadelphia Country : Role : Research Scientist
Job Description:
The Bioinformatics Scientist II applies knowledge of biology, bioinformatics algorithms and analysis platforms to consult and collaborate with investigators on their projects and to generate academic output as part of our research teams. Activities include experimental design and writing, analysis of data, and creation of scientifically rigorous visualizations, communications, and presentations of results. The Scientist will be working with a diverse and highly skilled bioinformatics team at the Children’s Hospital of Philadelphia (CHOP). Candidates must be able to show proficiency in development of data analysis systems, such as sequencing analysis pipelines and automation for analysis of high-throughput data. Candidates should have an excellent understanding of the strengths and limitations of commonly used data generating platforms as they apply to experimental endpoints and will readily be able to set expectations and defend results through frequent and direct communication with collaborators. Job Responsibilities :Required Experience:
Additional Info:
Shift: Days Employment Status: AF - Active - Regular - Full Time All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption. Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer). Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status. VEVRAA Federal Contractor/Seeking priority referrals for protected veterans. Please contact our hiring official with any referrals or questions. CHOP Careers Contact Talent Acquisition 2716 South Street, 6th Floor Philadelphia, PA 19146 Phone: 866-820-9288 Email: TalentAcquisition@email.chop.edu [Click Here to Access the Original Job Post]
The Bioinformatics Scientist II applies knowledge of biology, bioinformatics algorithms and analysis platforms to consult and collaborate with investigators on their projects and to generate academic output as part of our research teams. Activities include experimental design and writing, analysis of data, and creation of scientifically rigorous visualizations, communications, and presentations of results. The Scientist will be working with a diverse and highly skilled bioinformatics team at the Children’s Hospital of Philadelphia (CHOP). Candidates must be able to show proficiency in development of data analysis systems, such as sequencing analysis pipelines and automation for analysis of high-throughput data. Candidates should have an excellent understanding of the strengths and limitations of commonly used data generating platforms as they apply to experimental endpoints and will readily be able to set expectations and defend results through frequent and direct communication with collaborators. Job Responsibilities :
- Using standard pipelines for data processing and manipulation in advance of performing analysis in a manner that best enables the analysis plan
- Contributing to the development of additional pipeline functionality and changes by providing knowledge of both collaboration-specific requirements and bioinformatics discipline advances
- Advocating for specific collaboration requirements for continual advancement of shared pipeline and code resources
- Providing collaboration-specific transparency for data processing and pre-analysis, including sample- and cohort-level status
- Develop best practices for project-based code development, QC, and execution consist with the expectations of specific collaborations
- Regularly seek peer-to-peer code reviews by participating in informal and formal critical code reviews
- Analyze data of high complexity by applying sound statistical and commonly accepted bioinformatics methods to -omics data primarily under the direction of the collaborative project team
- Develop robust analysis plans independently with regular peer-to-peer review in both informal and formal settings
- Incorporate more advanced applications and methods into analysis
- Develop at least one “specialty” analytical or biomedical area that serves the collaborative team
- Establish role within a collaborative project team as primary bioinformatics resource
- Contribute to and influence project-level management by serving as bioinformatics point
- Define and promote boundaries of support by assessing all stakeholders, including bioinformatics management, collaborator expectations, and funding levels and mechanisms
- Regularly discuss satisfaction and expectations with collaborators; continually advocate for clear understanding of role
- Develop new collaborations with supervision
- Develop presentations, grant sections, and manuscript sections with subsequent review by peers and mentors.
- Regularly contribute to bioinformatics-focused manuscripts and publications
- Regularly contribute to podium presentations and posters
- Contribute to bioinformatics sections of grant and award proposals
Required Education and Experience
Required Education: Bachelor’s Degree in biological or computational discipline.- At least three (3) years of experience in applied bioinformatics, genomics, and computational work.
- Experience with management and analysis of complex data types.
- Experience with genomic/proteomic data analysis methods.
- MS or Ph.D. in a biological, computational or related discipline.
- At least three (3) years of experience in applied bioinformatics, genomics and computation.
- Working experience with next generation sequencing data using common tools against major databases and data standards in the field, including any of BWA/Novoalign, STAR, GATK, freebayes, samtools, Picard, SnpEff, MACS, realigner, or other tools and resources, e.g. sequence retrieval, alignment and clustering techniques, expression profiling and protein related analysis.
- Working knowledge and understanding of algorithms, data structures, and scientific programming
- Proficiency with any scripting programming languages such as Python, Perl, or R.
- Pipeline development, analysis, and troubleshooting experience with multi-omics data including whole genome and exome, RNA-Seq, targeted sequencing, ChIP-Seq, ATAC-Seq, SNP and methylation arrays
- Proficiency in Unix/Linux operating systems.
- Ability to work efficiently on multiple projects with guidance.
- Strong working knowledge of statistics including but not limited to hypothesis testing tools, power analysis, and the ability to aid researchers in experimental design
- Ability to communicate scientific and informatics concepts to a wide range of audiences.
- Excellent interpersonal skills to interact with both research and technical staff.
- Familiarity with repositories of genomic data sets and analysis tools, such as UCSC Genome Browser, Bioconductor, ENCODE, TCGA, and NCBI databases.
- Cluster experience, cloud computing, software version control (github), and software work flow management system (snakemake) are highly desirable but not necessary.
- Working knowledge or training in advanced biomedical research is a plus.
- Knowledge of technologies commonly used in biological labs, such as PCR, cloning, electrophoresis gels, and cell culture will help.
Requeriments :
Skills :
- Bioinformatics
- Biology
- genomic
- Lunix/Unix
- Next Generation Sequencing
- Programing in Python
- Programing Skills
- Programming in PERL
- Programming in R
- RNA-seq
- Statistics
- Version Control
Areas :
Additional Info:
Shift: Days Employment Status: AF - Active - Regular - Full Time All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption. Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer). Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status. VEVRAA Federal Contractor/Seeking priority referrals for protected veterans. Please contact our hiring official with any referrals or questions. CHOP Careers Contact Talent Acquisition 2716 South Street, 6th Floor Philadelphia, PA 19146 Phone: 866-820-9288 Email: TalentAcquisition@email.chop.edu [Click Here to Access the Original Job Post]