Bioinformatics Specialist I

Job ID: 246988364
Job date: 2016-12-09
End Date:

Company : Partners Healthcare 

Country :

Role : Research Scientist 


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Job Description:
Generation and computational analyses of mouse and human molecular (e.g. RNA-seq, chip-seq, DNA-seq) datasets, induced pluripotent stem cell-based datasets (e.g. high-throughput small molecule screens, high content imaging), computational data management and optimization of new analysis pipelines as required by evolving Huntington’s disease genetic projects spearheaded by the MacDonald laboratory.

Principal Duties And Responsibilities:

In an independent manner, perform computational analyses of next-generation sequencing data from genetic cohorts to identify and classify sequence variants (e.g. sequence variant calls Ingenuity package). Generate high-content molecular biology (e.g. PCR-based whole genome sequencing) and cell-culture phenotyping based (e.g. immunocytochemical and perturbagen-small molecule screens) datasets, especially focusing on patient induced pluripotent stem culture. Optimize computational tools and pipelines for analyses of these datasets to discover molecular and cellular signatures of effects of the Huntington’s disease mutation. Provide data annotation (e.g. KEGG, Drugbank, OMIM, etc.). Provide graphical and text outputs of analyses, summary statistics and tracking of contributing datasets. Provide assistance to collaborators seeking advice on study design, data generation and computational approaches to high-content data projects.

Skills/Abilities/Competencies Required:

Understanding of genetics and molecular biology as applied to computational biology and disease research

Understanding of basic computational packages related to analysis of sequence data.

Understanding of basic computational packages related to analysis of cell-based high-throughput screening data.

Ability to learn new computational skills.

Good interpersonal and communication skills.

Experience in working with cell culture patient derived induced pluripotent stem cell systems and datasets is preferred.

Education: BS/BA is required in Bioinformatics, Computer Science, or related field

Experience: Directly related experience in Bioinformatics/Computer Science and cell culture is strongly preferred


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Additional Info:
Working Conditions: Research Building with Office and Laboratory Environment.

Primary Location: MA-Boston-185 Cambridge - MGH

Work Locations: 185 Cambridge - MGH

Job: IT/Health IT/Informatics - Other

Organization: Massachusetts General Hospital(MGH) Schedule: Full-time

Standard Hours: 40

Shift: Day Job

Employee Status: Regular

Recruiting Department: MGH CHGR - Central Admin

Job Posting: Dec 9, 2016

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