Job Description:
We are seeking a highly qualified individual with relevant experience for a position in our toxicology group who shares the passion of our core principles and culture. As a computational biologist/ discovery toxicologist working on the toxicology team, you will develop and apply bioinformatics tools to analyze complex animal and human datasets across several antisense platforms. These analyses will inform broad platform behavior across chemical classes and interspecies relationships. The effort will also develop hypotheses on the mechanism of toxicities through the analysis and interrogation of platform/compound-centric, toxicology data. The ideal candidate will work collaboratively on discovery and computational projects across multiple disciplinary areas to develop strategies to improve the activity and tolerability of antisense oligonucleotides. So, join us and experience our unique culture while developing and expanding your career. RESPONSIBILITIES:
Additional Info:
Ionis Pharmaceuticals, Inc., located in the North San Diego County city of Carlsbad, is the industry leader in the discovery and development of antisense drugs. Ionis was founded in 1989 in order to create innovative therapies to improve and transform the lives of patients with serious, rare diseases. We currently have an active pipeline of 30 drugs in development covering a wide array of therapeutic areas. The Company establishes partnerships with large pharmaceutical and smaller biotechnology companies that provide dedicated and focused drug development and technology in order to maximize the potential of the technology we pioneered. This strategy provides Ionis with significant financial strength through a continuing stream of revenue from upfront license fees and milestone payments. In this way, we remain a powerhouse in antisense technology, discovering innovative ways to treat disease while remaining small with a core, dedicated group of employees. Join Ionis to work in a fast-paced, innovating, exciting, motivating and rewarding environment designed to foster innovation and scientific excellence. Our founding goals have changed little in 25 years and our success is a direct result of our outstanding employees. We are interested in bringing together individuals with different skill sets into this creative environment to be part of a productive team. Excellent salary and benefits package offered. For more information about Ionis and to apply for this position, please visit our website, www.ionispharma.com. Reference Requisition # 17-0117 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. [Click Here to Access the Original Job Post]
We are seeking a highly qualified individual with relevant experience for a position in our toxicology group who shares the passion of our core principles and culture. As a computational biologist/ discovery toxicologist working on the toxicology team, you will develop and apply bioinformatics tools to analyze complex animal and human datasets across several antisense platforms. These analyses will inform broad platform behavior across chemical classes and interspecies relationships. The effort will also develop hypotheses on the mechanism of toxicities through the analysis and interrogation of platform/compound-centric, toxicology data. The ideal candidate will work collaboratively on discovery and computational projects across multiple disciplinary areas to develop strategies to improve the activity and tolerability of antisense oligonucleotides. So, join us and experience our unique culture while developing and expanding your career. RESPONSIBILITIES:
- Work collaboratively with the bioinformatics and genomics team to design, develop and apply computational biology methods to assist in the integration, analysis and visualization of large, complex toxicological datasets
- Leverage multi ‘omic’ datasets including genomic variation, transcriptomic, proteomic, and metabolomic to further our understanding of the general mechanism of oligonucleotide toxicity and drive the improvement of early risk assessment strategies through the identification of toxicological pathways that are applicable across various therapeutic areas
- Provide leadership to leverage the new SEND Warehouse Animal Pharmacology and Tolerability Database to streamline companywide analysis of in-life data
- Performs data collection and curation
- Develop and automate DB Preclinical and Clinical queries
- Work as part of a team of safety assessment scientists and more broadly pathology, and early drug discovery teams to assist in the implementation discovery toxicology strategy
- Identification of on- and off-target pharmacology risks and identify de-risking strategies to enable the selection and progression of optimized drug candidates
- M.S. or Ph.D. in bioinformatics, toxicology, pharmacology, cellular biology, or neuroscience
- 4 years of experience in research with a proven track record of accomplishments, including publications in top tier scientific journals
- A deep foundational understanding in both biology and computational methods
- A solid foundation in statistical methods and experience using machine learning algorithms and data mining methods
- Strong experience with python and the associated scientific programing libraries (e.g. pandas, numpy, scipy, scikit-learn, Jupyter, seaborn, matplotlib).
- Comfortable working in a linux/unix environment
- Experience with JMP and JSL a plus
- Familiarity with database curation/maintenance, SQL
- Expert at analyzing genome, transcriptome, and proteomic datasets
- Knowledge of publicly available databases (i.e. ENCODE, GEO)
- Experience with open source NGS analysis software, analysis pipelines
- Familiarity with pathway analysis
- Can manage multiple assignments effectively in an intense and quickly evolving work environment
- Evidence of maturity, resourcefulness, and leadership potential
- Team oriented, highly collaborative
- Excellent oral and written communication skills, fluency in English
- Self-starter who is highly motivated and not afraid to take risks
Requeriments :
Skills :
- Bioinformatics
- Biology
- Computational Biology
- Data Mining
- genomic
- Lunix/Unix
- Machine Learning
- Next Generation Sequencing
- Programing in Python
- SQL
- Statistics
- Transcriptomics
Areas :
Additional Info:
Ionis Pharmaceuticals, Inc., located in the North San Diego County city of Carlsbad, is the industry leader in the discovery and development of antisense drugs. Ionis was founded in 1989 in order to create innovative therapies to improve and transform the lives of patients with serious, rare diseases. We currently have an active pipeline of 30 drugs in development covering a wide array of therapeutic areas. The Company establishes partnerships with large pharmaceutical and smaller biotechnology companies that provide dedicated and focused drug development and technology in order to maximize the potential of the technology we pioneered. This strategy provides Ionis with significant financial strength through a continuing stream of revenue from upfront license fees and milestone payments. In this way, we remain a powerhouse in antisense technology, discovering innovative ways to treat disease while remaining small with a core, dedicated group of employees. Join Ionis to work in a fast-paced, innovating, exciting, motivating and rewarding environment designed to foster innovation and scientific excellence. Our founding goals have changed little in 25 years and our success is a direct result of our outstanding employees. We are interested in bringing together individuals with different skill sets into this creative environment to be part of a productive team. Excellent salary and benefits package offered. For more information about Ionis and to apply for this position, please visit our website, www.ionispharma.com. Reference Requisition # 17-0117 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. [Click Here to Access the Original Job Post]