Job ID: 617383
Job date: 2017-06-16
End Date:
Company : Novo Nordisk Country : Role : Research Scientist
Job date: 2017-06-16
End Date:
Company : Novo Nordisk Country : Role : Research Scientist
Job Description:
We are seeking talented scientists who want to innovate at Novo Nordisk Research Centre Oxford and participate in changing the quality of life for millions of people with diabetes. The Position: Our new Novo Nordisk Research Centre Oxford (NNRCO) Advanced Genomics team is seeking an experienced and creative computational biologist for a challenging opportunity to study the mechanisms behind fatty liver disease, insulin resistance, and type 2 diabetes. Broadly, your responsibility will be modelling single-cell genomic data from ex vivo and 3D in vitro liver models used in large CRISPR and drug target screens. The team is interdisciplinary, being both wet- and dry-lab, and so the role will best suit an individual intellectually stimulated by the science and in shaping the questions being asked. The primary project you will lead will consider how to design and model single-cell CRISPR experiments to understand and predict genetic epistasis and cell microenvironment effects. You will be expected to collaborate with cross-functional NNRCO teams in areas beyond your expertise (such as imaging), be comfortable with managing your own bioinformatic pipelines, advise on complex experimental design, and report results clearly to diabetes researchers within NNRCO, Oxford University and Global Research, Novo Nordisk. The role is permanent, aimed at senior postdocs and computational researchers interested in shaping the culture of a new team, and mentoring junior members as a step towards leading their own team in academia or industry. This is a unique opportunity for ambitious computational biologists who enjoy a fast paced environment where creative intellectual independence and keenness to publish high impact work are actively encouraged. Applicants are asked to clearly indicate, in a two page cover letter, functional genomic (especially RNA-seq. and epigenetic) and experimental design expertise, with examples of large projects in which you have shaped the science. Please also include how you propose to model gene-gene and gene-environment interactions using single-cell pooled CRISPR in human liver spheroids of a few thousand cells each, and how your proposal might improve on published methods. Candidates invited to interview will be expected to present their proposal in detail. A third appendix/references page may be included with the cover letter. Qualifications: You hold a data sciences / quantitative Ph.D. degree or equivalent, (such as statistical genomics, computational biology, or machine learning) and have several years of experience in sequencing functional genomics. We expect you to be flexible, open to new ideas, ambitious, and result oriented. The job requires proficiency in English and excellent communication and collaboration skills. You will be part of a team in a highly dynamic and challenging environment.
Additional Info:
Working at Novo Nordisk: At Novo Nordisk, we use our skills, dedication and ambition to help people with diabetes. We offer the chance to be part of a truly global work place, where passion and engagement are met with opportunities for professional and personal development. About the NNRCO Institute and the Advanced Genomics Department: Novo Nordisk is hiring scientists for our new academic-industrial hybrid research institute focused on discovery biology related to type 2 diabetes. The Novo Nordisk Research Centre Oxford (NNRCO) will interface fully with the world-leading academic type 2 diabetes research community at Oxford University. NNRCO, established in January 2017, is establishing a world-class scientific team and we hope you will join us! The institute will consist of junior and senior level faculty, post-doctoral fellows, technicians and Ph.D. students. In 2017, NNRCO will have 4 Departments: Advanced Genomics; Bioinformatics; Stem Cell Engineering; and High-Throughput Imaging, with 3 more Departments following in 2018; Proteomics, In Vitro Physiology, and In Vivo Physiology. This position is for the Advanced Genomics Department, but a successful applicant will be expected to collaborate throughout the Institution. The NNRCO is part of Novo Nordisk’s Global Research Unit, which specialises in the discovery of biological medicines for the treatment of type 1 and 2 diabetes. We also discover and develop new innovative biopharmaceuticals for haemophilia and growth disorders. Furthermore, we conduct stem cell and beta cell regeneration research and other early-stage investigations aimed at finding a cure for diabetes, as well as exploring novel treatments for obesity and long-term, micro-vascular complications of diabetes….[Click Here to Access the Original Job Post]
We are seeking talented scientists who want to innovate at Novo Nordisk Research Centre Oxford and participate in changing the quality of life for millions of people with diabetes. The Position: Our new Novo Nordisk Research Centre Oxford (NNRCO) Advanced Genomics team is seeking an experienced and creative computational biologist for a challenging opportunity to study the mechanisms behind fatty liver disease, insulin resistance, and type 2 diabetes. Broadly, your responsibility will be modelling single-cell genomic data from ex vivo and 3D in vitro liver models used in large CRISPR and drug target screens. The team is interdisciplinary, being both wet- and dry-lab, and so the role will best suit an individual intellectually stimulated by the science and in shaping the questions being asked. The primary project you will lead will consider how to design and model single-cell CRISPR experiments to understand and predict genetic epistasis and cell microenvironment effects. You will be expected to collaborate with cross-functional NNRCO teams in areas beyond your expertise (such as imaging), be comfortable with managing your own bioinformatic pipelines, advise on complex experimental design, and report results clearly to diabetes researchers within NNRCO, Oxford University and Global Research, Novo Nordisk. The role is permanent, aimed at senior postdocs and computational researchers interested in shaping the culture of a new team, and mentoring junior members as a step towards leading their own team in academia or industry. This is a unique opportunity for ambitious computational biologists who enjoy a fast paced environment where creative intellectual independence and keenness to publish high impact work are actively encouraged. Applicants are asked to clearly indicate, in a two page cover letter, functional genomic (especially RNA-seq. and epigenetic) and experimental design expertise, with examples of large projects in which you have shaped the science. Please also include how you propose to model gene-gene and gene-environment interactions using single-cell pooled CRISPR in human liver spheroids of a few thousand cells each, and how your proposal might improve on published methods. Candidates invited to interview will be expected to present their proposal in detail. A third appendix/references page may be included with the cover letter. Qualifications: You hold a data sciences / quantitative Ph.D. degree or equivalent, (such as statistical genomics, computational biology, or machine learning) and have several years of experience in sequencing functional genomics. We expect you to be flexible, open to new ideas, ambitious, and result oriented. The job requires proficiency in English and excellent communication and collaboration skills. You will be part of a team in a highly dynamic and challenging environment.
Requeriments :
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Additional Info:
Working at Novo Nordisk: At Novo Nordisk, we use our skills, dedication and ambition to help people with diabetes. We offer the chance to be part of a truly global work place, where passion and engagement are met with opportunities for professional and personal development. About the NNRCO Institute and the Advanced Genomics Department: Novo Nordisk is hiring scientists for our new academic-industrial hybrid research institute focused on discovery biology related to type 2 diabetes. The Novo Nordisk Research Centre Oxford (NNRCO) will interface fully with the world-leading academic type 2 diabetes research community at Oxford University. NNRCO, established in January 2017, is establishing a world-class scientific team and we hope you will join us! The institute will consist of junior and senior level faculty, post-doctoral fellows, technicians and Ph.D. students. In 2017, NNRCO will have 4 Departments: Advanced Genomics; Bioinformatics; Stem Cell Engineering; and High-Throughput Imaging, with 3 more Departments following in 2018; Proteomics, In Vitro Physiology, and In Vivo Physiology. This position is for the Advanced Genomics Department, but a successful applicant will be expected to collaborate throughout the Institution. The NNRCO is part of Novo Nordisk’s Global Research Unit, which specialises in the discovery of biological medicines for the treatment of type 1 and 2 diabetes. We also discover and develop new innovative biopharmaceuticals for haemophilia and growth disorders. Furthermore, we conduct stem cell and beta cell regeneration research and other early-stage investigations aimed at finding a cure for diabetes, as well as exploring novel treatments for obesity and long-term, micro-vascular complications of diabetes….[Click Here to Access the Original Job Post]