Job ID: 616041
Job date: 2017-05-28
End Date:
Company : Icahn School of Medicine at Mount Sinai Country : Role : Postdoc
Job date: 2017-05-28
End Date:
Company : Icahn School of Medicine at Mount Sinai Country : Role : Postdoc
Job Description:
The Functional Neurogenomics Lab studies the genetic mechanisms through which risk genetic variants increase vulnerability for neuropsychiatric diseases, including schizophrenia, bipolar disorder and Alzheimer’s disease. Successful candidates will join the Functional Neurogenomics Laboratory in the Departments of Genetics and Genomic Sciences and Psychiatry. They will be part of an interdisciplinary team that generates functional omics data and develops computational methods to analyze them in order to characterize the functional role of non-coding variants associated with neuropsychiatric disorders, including schizophrenia and Alzheimer’s disease. The successful applicant will develop computational tools and perform data analysis for annotating and interpreting large-scale human genomic (SNP array and whole exome/genome sequencing), transcriptomic (RNA-seq) and epigenomic (ATAC-seq and ChIP-seq) data. Projects will include computational and statistical analysis of functional sequencing studies generated from the Functional Neurogenomics Laboratory, working with collaborators in international consortia (CommonMind, PsychENCODE and Accelerating Medicines Partnership-Alzheimer’s Disease), statistical methods development and data analyses, and the integration of disease-implicated genetic variation, epigenetic, and gene expression data into pathway and network analyses. Additionally, the individual will be responsible for the organization and integration of these various datasets, communicating and publishing results. Responsibilities: • Develop and maintain genetic, genomic, and biological databases to annotate and interpret human genome data • Analyze next generation sequencing data, including whole genome, whole exome, RNA-Seq, Chip-Seq and ATAC-seq data • Develop and implement algorithms, statistical methods and software to analyze large-scale human sequencing data and perform integrative functional analysis • Publish and present novel research findings in academic journals and conferences Job requirements: • PhD in Computational Biology, Bioinformatics, Computer Science, Biology, Biomedical Engineering, Computer Engineering, Genetics or related field • Strong genomics and genetics background • Experience with biological datasets and next generation sequencing data • Demonstrated experience designing computational methods and tools, including prior experience with algorithms relevant to computational biology, and skill and experience with statistical analysis • Outstanding programming skills in at least two of these languages on a Linux environment: Python, R, bash, Perl, Java, and C++ • Excellent communication a skills with a focus on teamwork and creating usable and accessible research software tools
Additional Info:
High Performance Computing (HPC) at ISMMS Our HPC group is dedicated to advancing research at the ISMMS by administering a sustainable state-of-the-art computational infrastructure, and providing technology services. Current compute and storage resources exceed 12,000 cores and 10 petabytes of disk. Our HPC provides 140 teraflops peak speed and over 85 million CPU hours per year. About the Icahn Institute for Genomics and Multiscale Biology at ISMMS The Icahn Institute was founded in 2011 to help advance precision medicine with cutting-edge technologies, novel partnerships between the public and private sector, and world-class computational and analytical resources. About the Department of Psychiatry at ISMMS The Department of Psychiatry at Mount Sinai, a vibrant community of clinicians, researchers, educators, and trainees committed to discovering the causes of and treatments for mental and emotional disorders. We are ranked among the nation’s top psychiatry departments for funding from the National Institutes of Health. About the Friedman Brain Institute at ISMMS The Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai is one of the world’s premier institutions dedicated to advancing our understanding of brain and spinal cord disorders, and driving innovative approaches to new treatments and diagnostic tests through translational research. We are committed to the best in education, research, and clinical care. About the Icahn School of Medicine at Mount Sinai The ISMMS is an international leader in medical and scientific training, biomedical research, and patient care. It is the medical school for the Mount Sinai Health System, which includes seven hospital campuses, and has more than 5,000 faculty and nearly 2,000 students, residents and fellows. Our unwavering pursuit of intellectual exchange, breakthrough research, and multidisciplinary teamwork propels us ever forward in biomedical discoveries and advances. We pursue ideas that often challenge conventional wisdom to revolutionize the practice of medicine and produce dramatically better outcomes for patients.[Click Here to Access the Original Job Post]
The Functional Neurogenomics Lab studies the genetic mechanisms through which risk genetic variants increase vulnerability for neuropsychiatric diseases, including schizophrenia, bipolar disorder and Alzheimer’s disease. Successful candidates will join the Functional Neurogenomics Laboratory in the Departments of Genetics and Genomic Sciences and Psychiatry. They will be part of an interdisciplinary team that generates functional omics data and develops computational methods to analyze them in order to characterize the functional role of non-coding variants associated with neuropsychiatric disorders, including schizophrenia and Alzheimer’s disease. The successful applicant will develop computational tools and perform data analysis for annotating and interpreting large-scale human genomic (SNP array and whole exome/genome sequencing), transcriptomic (RNA-seq) and epigenomic (ATAC-seq and ChIP-seq) data. Projects will include computational and statistical analysis of functional sequencing studies generated from the Functional Neurogenomics Laboratory, working with collaborators in international consortia (CommonMind, PsychENCODE and Accelerating Medicines Partnership-Alzheimer’s Disease), statistical methods development and data analyses, and the integration of disease-implicated genetic variation, epigenetic, and gene expression data into pathway and network analyses. Additionally, the individual will be responsible for the organization and integration of these various datasets, communicating and publishing results. Responsibilities: • Develop and maintain genetic, genomic, and biological databases to annotate and interpret human genome data • Analyze next generation sequencing data, including whole genome, whole exome, RNA-Seq, Chip-Seq and ATAC-seq data • Develop and implement algorithms, statistical methods and software to analyze large-scale human sequencing data and perform integrative functional analysis • Publish and present novel research findings in academic journals and conferences Job requirements: • PhD in Computational Biology, Bioinformatics, Computer Science, Biology, Biomedical Engineering, Computer Engineering, Genetics or related field • Strong genomics and genetics background • Experience with biological datasets and next generation sequencing data • Demonstrated experience designing computational methods and tools, including prior experience with algorithms relevant to computational biology, and skill and experience with statistical analysis • Outstanding programming skills in at least two of these languages on a Linux environment: Python, R, bash, Perl, Java, and C++ • Excellent communication a skills with a focus on teamwork and creating usable and accessible research software tools
Requeriments :
Skills :
- Genetics
- genomic
- Lunix/Unix
- Next Generation Sequencing
- Programing in C++
- Programing in Python
- Programing Skills
- Programming in Java
- Programming in PERL
- Programming in R
- RNA-seq
- Statistics
Areas :
Additional Info:
High Performance Computing (HPC) at ISMMS Our HPC group is dedicated to advancing research at the ISMMS by administering a sustainable state-of-the-art computational infrastructure, and providing technology services. Current compute and storage resources exceed 12,000 cores and 10 petabytes of disk. Our HPC provides 140 teraflops peak speed and over 85 million CPU hours per year. About the Icahn Institute for Genomics and Multiscale Biology at ISMMS The Icahn Institute was founded in 2011 to help advance precision medicine with cutting-edge technologies, novel partnerships between the public and private sector, and world-class computational and analytical resources. About the Department of Psychiatry at ISMMS The Department of Psychiatry at Mount Sinai, a vibrant community of clinicians, researchers, educators, and trainees committed to discovering the causes of and treatments for mental and emotional disorders. We are ranked among the nation’s top psychiatry departments for funding from the National Institutes of Health. About the Friedman Brain Institute at ISMMS The Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai is one of the world’s premier institutions dedicated to advancing our understanding of brain and spinal cord disorders, and driving innovative approaches to new treatments and diagnostic tests through translational research. We are committed to the best in education, research, and clinical care. About the Icahn School of Medicine at Mount Sinai The ISMMS is an international leader in medical and scientific training, biomedical research, and patient care. It is the medical school for the Mount Sinai Health System, which includes seven hospital campuses, and has more than 5,000 faculty and nearly 2,000 students, residents and fellows. Our unwavering pursuit of intellectual exchange, breakthrough research, and multidisciplinary teamwork propels us ever forward in biomedical discoveries and advances. We pursue ideas that often challenge conventional wisdom to revolutionize the practice of medicine and produce dramatically better outcomes for patients.[Click Here to Access the Original Job Post]