Job Description:
Position: Diagnostic Bioinformatician Site: MaRS Centre, Toronto Department: Diagnostic Development Reports To: Director, Diagnostic Development Salary: Commensurate with level of experience Hours: 35 hours/week Status: Full-time, Temporary (one year) Responsibilities: • Preprocessing, processing and interpreting large next generation sequencing data sets to quantify gene expression, copy number aberrations and simple somatic mutations; • Mining data sets for biomarkers that stratify patients according to their risk of disease progression and/or predict patient response to specific therapies; • Exploring external biological databases, suggesting integration approaches and building prototypes to evaluate and fine-tune integration plan;Developing tools for data quality control, data validation and reporting; • Interacting with the Director to design and develop bioinformatics and statistical algorithm approaches for clinical diagnostics. The incumbent will be co-mentored by a Bioinformatics PI; • Liaising with other OICR experts in next generation sequencing, bioinformatics, and biostatistics to validate approaches; • Preparing documentation for data specifications and analysis workflows; • Participating in publications, grant writing and program funding review.
Additional Info:
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Position: Diagnostic Bioinformatician Site: MaRS Centre, Toronto Department: Diagnostic Development Reports To: Director, Diagnostic Development Salary: Commensurate with level of experience Hours: 35 hours/week Status: Full-time, Temporary (one year) Responsibilities: • Preprocessing, processing and interpreting large next generation sequencing data sets to quantify gene expression, copy number aberrations and simple somatic mutations; • Mining data sets for biomarkers that stratify patients according to their risk of disease progression and/or predict patient response to specific therapies; • Exploring external biological databases, suggesting integration approaches and building prototypes to evaluate and fine-tune integration plan;Developing tools for data quality control, data validation and reporting; • Interacting with the Director to design and develop bioinformatics and statistical algorithm approaches for clinical diagnostics. The incumbent will be co-mentored by a Bioinformatics PI; • Liaising with other OICR experts in next generation sequencing, bioinformatics, and biostatistics to validate approaches; • Preparing documentation for data specifications and analysis workflows; • Participating in publications, grant writing and program funding review.
Qualifications:
Required: • PhD or post-doctorate in computational biology/bioinformatics or related field with 3-5 years professional experience; • Knowledge of genomics, molecular and/or cancer biology; • Experience with the analysis of next generation sequencing data; • Experience with bioinformatics resources, databases, tools and common standard formats used in NGS; • Strong scripting skills (R/python/perl), expertise in a statistical environment (matlab or R), and comfort working in Linux environment; • Experience in biostatistics, particularly survival or Bayesian techniques; • Excellent writing and communication skills; • Experience with meeting publication, grant and experimental deadlines; • Ability to work independently and mentored by our Informatics team. Preferred: • Experience with and in-depth knowledge of data modeling; • Experience in machine-learning methods; • Experience with clinical trials an asset; • Previous experience in developing algorithms that have been implemented in a clinical diagnostic test highly preferred; • Post-graduate research work in network modelling of cancer cell signaling networks, cancer heterogeneity and transcriptional regulatory networks; • Previous experience working with Nanostring data is a plus; • Data-visualization capabilities for large datasets. Location: Toronto, QC, Canada Job Type: Programmer/Developer Degree Level Required: PhDRequeriments :
Skills :
- Bioinformatics
- Bioinformatics Databases
- Biostatistics
- Cancer biology
- Data Mining
- genomic
- Lunix/Unix
- Machine Learning
- Modeling
- molecular biology
- Next Generation Sequencing
- Programing in Python
- Programming in Matlab
- Programming in PERL
- Programming in R
- Statistics
Areas :
Additional Info:
[Click Here to Access the Original Job Post]