Job ID:
Job date: 2014-09-29
End Date:
Company : Global Blood Therapeutics Country : Role : Research Scientist
Job date: 2014-09-29
End Date:
Company : Global Blood Therapeutics Country : Role : Research Scientist
Job Description:
Additional Info:
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Job description
Utilize expertise in protein structure/function, computational methodologies and structure-based drug design to advise project teams and the scientific leadership of the company; influence project selection and strategy ultimately resulting in the discovery of small molecule clinical candidates
Roles/Deliverables
- Functions as an influential project team member; guides the direction of compound design strategies in projects
- Serves as an expert in the evaluation of protein constructs, crystal structures and other structural biology data
- Investigates the protein dynamics of systems through the integration of computational and experimental techniques
- Evaluates homology of various proteins; may develop homology or pharmacophore models for use by project teams
- Conducts high-level calculations for project teams
- Contributes to the conception, evaluation and initiation of new projects
- May develop ADMET predictive tools for use by scientists from multiple disciplines
- Maintains a current understanding of computational science literature and methodology, as well as the scientific literature related to specific drug discovery projects
- Demonstrates inter-disciplinary knowledge of drug discovery (e.g., chemistry, enzymology, cellular pharmacology, pharmacokinetics) and is able to use this knowledge to influence project strategy
- Develops and contributes to company’s intellectual property domain by way of patents and/or publications
- Prepares and organizes data for presentations; presents written and oral reports; may communicate research efforts to collaborators and corporate partners or at scientific meetings
- May lead a group or project
Desired Skills and Experience
- PhD in a relevant field such as Computational, Physical, or Theoretical Chemistry; Molecular Biophysics; or Computational Biology with at least 5 years of experience in a biotech or pharmaceutical company
- Experience with iterative structure-guided compound optimization
- Experience programming in Perl, Python, C, Fortran, Java or C++
- Experience in the following areas: protein binding site analyses, computation of protein-ligand binding affinities, high-throughput 3D pharmacophore and/or docking algorithms, homology modeling, ab initio calculations, molecular dynamics simulations, development of QM/MM models
- Strong oral and written communications skills
- Strong publication record
- Track record of impact on successful drug discovery program(s)
Requeriments :
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Additional Info:
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