Job ID:
Job date: 2014-11-14
End Date:
Company : Regeneron Pharmaceuticals Country : Role : Research Scientist
Job date: 2014-11-14
End Date:
Company : Regeneron Pharmaceuticals Country : Role : Research Scientist
Job Description:
The Regeneron Genetics Center is a wholly-owned subsidiary of the Company organized to collaborate with health systems and research groups to elucidate, on a large scale, genetic factors that cause or influence a range of human diseases. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the Center will specialize in ultra-high-throughput exome sequencing and computational biology; discovery of genotype-phenotype associations through linkage to well-annotated de-identified patient electronic medical records; and validation of discoveries using Regeneron’s VelociGene® technology. Our interests encompass a breadth of different areas such as Mendelian and family frameworks, large-scale population genetics (both common and rare variants), and gene-gene interactions. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and patients of collaborating health-care systems, and identifying novel targets for drug development.
The Head of Clinical Informatics will be responsible for leading large-scale analyses involving clinical and phenotypic data for genetics studies as well as clinical development and commercial programs. Responsibilities will include managing large-scale phenotypic datasets, including de-identified EMR extracts from external collaborators, targeted clinical datasets in selected cohorts, and internal datasets from clinical trials and other human subject research. The position will involve working with a team of database administrators, biostatisticians, clinical scientists, and programmers to structure and mine clinical and phenotypic data sets and support genomic studies and association analyses. Specifically, the incumbent will lead efforts to establish data models, user interfaces and tools for querying datasets, and develop sophisticated analyses of the data applied towards genetics studies and clinical research. The position will require coordination and collaboration with other functional area heads within the department, research and clinical scientists at Regeneron, and external collaborators.
· Manage a team of programmers, database administrators, statisticians, and clinical scientists, as well as external collaborators to oversee EMR data extraction, transformation and processing from multiple health system partners.
· Oversee the mining and curating of these phenotypic datasets with primary responsibility in supporting the department with identifying refined clinical phenotypes and cohorts of interest for “phenotype first” genomic analysis of associated samples and efficient data mining and association analysis in both phenotype first and genotype first queries.
· Oversee algorithm development, natural language processing (NLP) and textual mining of “scrubbed” and de-identified healthcare provider notes.
· Implement GUIs and GUXs such as i2b2 software to enable a scalable data warehousing and informatics framework and data mining/querying by department team members and broader Regeneron scientists.
· Close collaboration and coordination with external health system IT specialists, physicians, geneticists, and bioinformatics teams mining EMR and phenotypic data sets. Work with these collaborators to examine data and develop algorithms, rules engines, and querying tools to access and curate the phenotypic datasets.
Requirements
Experience and Required Skills:
Qualified candidates should have a PhD in relevant computational biology, computer science, or clinical informatics fields. MD preferred. At least 5-10 years of clinical informatics and EMR data analytics. Minimum of 3-5 years of experience in leading a mid-sized team. Familiarity with data mining, clinical databases, hospital health informatics databases including EPIC and other EMR (electronic medical records) databases. Familiarity with clinical data standards, ICD and SNOMED mapping, database architecture and administration, and SQL programming. Experience with HIPAA compliance standards and experience with IRB protocols around use of use of EMR data. Experience working closely with human genetics and bioinformatics investigators.
This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron Genetics Center's unwavering commitment to combining good science & good business.
To all agencies: Please, no phone calls or emails to any employee of Regeneron or the Regeneron Genetics Center about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron or the Regeneron Genetics Center via-email, the internet or in any form and/or method will be deemed the sole property of the Regeneron Genetics Center, unless such search firms/employment agencies were engaged by Regeneron or the Regeneron Genetics Center for this position and a valid agreement with either Regeneron or the Regeneron Genetics Center is in place. In the event a candidate who was submitted outside of the Regeneron or Regeneron Genetics Center agency engagement process is hired, no fee or payment of any kind will be paid.
RGC is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.
Additional Info:
[Click Here to Access the Original Job Post]
The Regeneron Genetics Center is a wholly-owned subsidiary of the Company organized to collaborate with health systems and research groups to elucidate, on a large scale, genetic factors that cause or influence a range of human diseases. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the Center will specialize in ultra-high-throughput exome sequencing and computational biology; discovery of genotype-phenotype associations through linkage to well-annotated de-identified patient electronic medical records; and validation of discoveries using Regeneron’s VelociGene® technology. Our interests encompass a breadth of different areas such as Mendelian and family frameworks, large-scale population genetics (both common and rare variants), and gene-gene interactions. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and patients of collaborating health-care systems, and identifying novel targets for drug development.
The Head of Clinical Informatics will be responsible for leading large-scale analyses involving clinical and phenotypic data for genetics studies as well as clinical development and commercial programs. Responsibilities will include managing large-scale phenotypic datasets, including de-identified EMR extracts from external collaborators, targeted clinical datasets in selected cohorts, and internal datasets from clinical trials and other human subject research. The position will involve working with a team of database administrators, biostatisticians, clinical scientists, and programmers to structure and mine clinical and phenotypic data sets and support genomic studies and association analyses. Specifically, the incumbent will lead efforts to establish data models, user interfaces and tools for querying datasets, and develop sophisticated analyses of the data applied towards genetics studies and clinical research. The position will require coordination and collaboration with other functional area heads within the department, research and clinical scientists at Regeneron, and external collaborators.
· Manage a team of programmers, database administrators, statisticians, and clinical scientists, as well as external collaborators to oversee EMR data extraction, transformation and processing from multiple health system partners.
· Oversee the mining and curating of these phenotypic datasets with primary responsibility in supporting the department with identifying refined clinical phenotypes and cohorts of interest for “phenotype first” genomic analysis of associated samples and efficient data mining and association analysis in both phenotype first and genotype first queries.
· Oversee algorithm development, natural language processing (NLP) and textual mining of “scrubbed” and de-identified healthcare provider notes.
· Implement GUIs and GUXs such as i2b2 software to enable a scalable data warehousing and informatics framework and data mining/querying by department team members and broader Regeneron scientists.
· Close collaboration and coordination with external health system IT specialists, physicians, geneticists, and bioinformatics teams mining EMR and phenotypic data sets. Work with these collaborators to examine data and develop algorithms, rules engines, and querying tools to access and curate the phenotypic datasets.
Requirements
Experience and Required Skills:
Qualified candidates should have a PhD in relevant computational biology, computer science, or clinical informatics fields. MD preferred. At least 5-10 years of clinical informatics and EMR data analytics. Minimum of 3-5 years of experience in leading a mid-sized team. Familiarity with data mining, clinical databases, hospital health informatics databases including EPIC and other EMR (electronic medical records) databases. Familiarity with clinical data standards, ICD and SNOMED mapping, database architecture and administration, and SQL programming. Experience with HIPAA compliance standards and experience with IRB protocols around use of use of EMR data. Experience working closely with human genetics and bioinformatics investigators.
This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron Genetics Center's unwavering commitment to combining good science & good business.
To all agencies: Please, no phone calls or emails to any employee of Regeneron or the Regeneron Genetics Center about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron or the Regeneron Genetics Center via-email, the internet or in any form and/or method will be deemed the sole property of the Regeneron Genetics Center, unless such search firms/employment agencies were engaged by Regeneron or the Regeneron Genetics Center for this position and a valid agreement with either Regeneron or the Regeneron Genetics Center is in place. In the event a candidate who was submitted outside of the Regeneron or Regeneron Genetics Center agency engagement process is hired, no fee or payment of any kind will be paid.
RGC is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.
Requeriments :
Skills :
Areas :
Additional Info:
[Click Here to Access the Original Job Post]