Job ID:
Job date: 2014-10-01
End Date:
Company : Seattle Genetics Country : Role : Research Scientist
Job date: 2014-10-01
End Date:
Company : Seattle Genetics Country : Role : Research Scientist
Job Description:
Head of Bioinformatics; Sr. Manager / Assoc. Dir. Primary Function
Additional Info:
[Click Here to Access the Original Job Post]
Head of Bioinformatics; Sr. Manager / Assoc. Dir. Primary Function
- Responsible for bioinformatics across all preclinical and clinical therapeutic areas at Seattle Genetics. Leads initiatives to understand disease pathogenesis and progression, drug mechanism of action, and response to therapies from a Bioinformatics perspective. Provides hands-on support as needed.
- Reports to: Head of Translational Medicine, or Head of Diagnostics/Biomarkers
- Plans, organizes, and directs the activities of Bioinformatics, including resource planning and budgeting
- Provides bioinformatics support to study and project teams
- Participates in establishing and maintaining policies, standards, and guidance for the operation of Bioinformatics
- Hires, mentors and manages employees. Selects, hires and monitors qualified and cost-effective contractors, consultants, and/or CROs.
- Oversees, plans for, and identifies prognostic, diagnostic, response, and safety markers using preclinical and clinical data, including Phase 0-4 clinical and biomarkers.
- Develops and implements analysis strategies for patient stratification, drug positioning and predictive modeling using clinical and biomarker data and state of the art bioinformatics tools and techniques.
- Integrates multi-modal multi-analyte clinical and biomarker data from preclinical studies, clinical trials and the literature to understand disease pathogenesis and progression, drug MOA, and response to therapies.
- Works closely with clinicians, preclinical and biomarker scientists and clinical statisticians to generate testable hypotheses, design experiments, and incorporate pharmacodynamics and biomarkers in study protocols.
- Communicates analyses results and interpretations to complex matrix teams of biomarker leads, clinicians, clinical statisticians, informaticians and preclinical scientists.
- Works closely with biomarker leads, clinical pharmacology and translational research teams to identify and address near-term and long-term bioinformatics needs for pre-clinical and clinical programs.
- Enhances and enables the clinicians, preclinical scientists, and biomarker leads to interact with biomarker data and analyses results.
- Ph.D. in Bioinformatics, Computational Biology, Biostatistics/Statistics or related field with at least 10 years relevant experience in biotech, pharma or academia, and 5 years of management experience
- Drug development experience in oncology and inflammation. Strong understanding of the disease biology in oncology and immunology.
- Working experience in the pharmaceutical industry preferably in clinical research.
- Strong background in Omic (RNA, proteomic, epigenetic) data analysis and biological interpretation.
- Proficiency using R /SAS and Bioconductor packages, commercial bioinformatics tools (ArrayStudio, Partek), data visualization tools (Spotfire, Cytoscape), molecular pathway analysis tools (Metacore, IPA), related languages (Java, C#, XML, Perl, C, C++, SQL) and commercial and publicly available biological databases (ArrayExpress/GEO, Oncomine, TCGA, 1000 Genomes etc.).
- Proficiency with biostatistics and data mining methodologies in conducting supervised and unsupervised analysis of Omic data.
- Proficiency with integration of multi-modal multi-analyte biomarker data with clinical data and knowledge management platforms.
- Proficiency with modeling and simulation of disease pathogenesis and drug mechanism of action.
- Familiarity with regulatory submissions, including NDA/BLA or PMA, in a relevant therapeutic area. Understanding of ICH guidelines and regulatory requirements.
- Ability to communicate efficiently with clinicians, preclinical scientists, biomarker scientists, biostatisticians and computational scientists. Ability to explain bioinformatics technical issues to technical and non-technical staff
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Additional Info:
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