Job ID: 4700
Job date: 2015-11-06
End Date:
Company : University of Texas Country : Role : Research Scientist
Job date: 2015-11-06
End Date:
Company : University of Texas Country : Role : Research Scientist
Job Description:
MD Anderson is known for providing cancer patients with exceptional care, which includes early access to innovative new treatments through clinical trials. The Institute for Applied Cancer Science (IACS) is a new hybrid model that uniquely combines the drug discovery capabilities of the biopharmaceutical industry and the extensive knowledge of biology found in academia with the expertise of MD Anderson's top clinicians. IACS has the singular goal of rapidly developing novel, effective and safe therapeutics that improve patient health. IACS executes programs with the highest probability of clinical success in a rigorous, goal-oriented, data-driven manner.
SUMMARY
The Institute Research Scientist participates in cross-functional research to identify and validate novel targets for neurodegenerative diseases, and translate these finding into novel therapeutic agents to benefit patients. An ideal candidate will be able to work in an interdisciplinary team to lead internal drug discovery efforts as well as to develop and implement biomarker strategies for drug discovery projects.
KEY FUNCTIONS
· Lead neuroscience drug discovery biology efforts to selection of lead candidate molecules and transition into clinical development, particularly in the area of neuroimmunology.
· Apply and develop cutting edge basic science tools and methodologies to develop complex strategies and enable advancement of neuroscience projects through leadership and experimental activities.
· Independently design, execute and interpret in vitro , ex-vivo and in vivo experiments to validate targets, optimize compound selection and explore therapeutic potential of novel neuroscience drug targets. Analyze data generated by various studies and leverage results for the design of future studies.
· Work with internal and external research and bioinformatics teams to utilize biological and genomic data sets to generate and test hypothesis for drug targets.
· Work with chemistry and pharmacology teams as part of drug discovery efforts to validate targets and optimize novel small molecule therapeutics.
· Design and develop appropriate animal models, cell and molecular assays to define mechanism of action for compounds, identify pharmacodynamic assays to be used in pre-clinical and clinical setting and test patient selection strategies.
· Adapt to new technologies and find solutions to related program studies.
· Develop extensive knowledge and experience in key areas of neuroimmunology including, but not limited to microglial physiology, neuropathies and Alzheimer’s disease.
· Interpret, present and report research findings at internal meeting and external scientific conferences.
WORKING CONDITIONS
Laboratory environment
Job Description - Requirements
Required: Bachelor's degree in Biology, Biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.
Preferred: Masters in one of the natural sciences or related field or PhD/Medical degree. PhD in Neuroscience, Neurobiology, Cell Biology or related degree or Medical degree.
Required: Ten years of relevant research laboratory experience. With Master's degree, eight years of required experience and with PhD, two years of required experience.
Preferred: At least two years of relevant experience in neuroimmunology and drug discovery research in biotech or pharmaceutical.
This position requires a highly self-motivated individual with outstanding organizational skills, the ability to effectively present results and conclusions to co-workers, collaborators and manager. Ability to work well under pressure and drive personal and team objectives that impact critical timelines is expected. A collaborative attitude is essential for this position.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Pivotal Position
Yes
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Additional Info:
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MD Anderson is known for providing cancer patients with exceptional care, which includes early access to innovative new treatments through clinical trials. The Institute for Applied Cancer Science (IACS) is a new hybrid model that uniquely combines the drug discovery capabilities of the biopharmaceutical industry and the extensive knowledge of biology found in academia with the expertise of MD Anderson's top clinicians. IACS has the singular goal of rapidly developing novel, effective and safe therapeutics that improve patient health. IACS executes programs with the highest probability of clinical success in a rigorous, goal-oriented, data-driven manner.
SUMMARY
The Institute Research Scientist participates in cross-functional research to identify and validate novel targets for neurodegenerative diseases, and translate these finding into novel therapeutic agents to benefit patients. An ideal candidate will be able to work in an interdisciplinary team to lead internal drug discovery efforts as well as to develop and implement biomarker strategies for drug discovery projects.
KEY FUNCTIONS
· Lead neuroscience drug discovery biology efforts to selection of lead candidate molecules and transition into clinical development, particularly in the area of neuroimmunology.
· Apply and develop cutting edge basic science tools and methodologies to develop complex strategies and enable advancement of neuroscience projects through leadership and experimental activities.
· Independently design, execute and interpret in vitro , ex-vivo and in vivo experiments to validate targets, optimize compound selection and explore therapeutic potential of novel neuroscience drug targets. Analyze data generated by various studies and leverage results for the design of future studies.
· Work with internal and external research and bioinformatics teams to utilize biological and genomic data sets to generate and test hypothesis for drug targets.
· Work with chemistry and pharmacology teams as part of drug discovery efforts to validate targets and optimize novel small molecule therapeutics.
· Design and develop appropriate animal models, cell and molecular assays to define mechanism of action for compounds, identify pharmacodynamic assays to be used in pre-clinical and clinical setting and test patient selection strategies.
· Adapt to new technologies and find solutions to related program studies.
· Develop extensive knowledge and experience in key areas of neuroimmunology including, but not limited to microglial physiology, neuropathies and Alzheimer’s disease.
· Interpret, present and report research findings at internal meeting and external scientific conferences.
WORKING CONDITIONS
Laboratory environment
Job Description - Requirements
Required: Bachelor's degree in Biology, Biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.
Preferred: Masters in one of the natural sciences or related field or PhD/Medical degree. PhD in Neuroscience, Neurobiology, Cell Biology or related degree or Medical degree.
Required: Ten years of relevant research laboratory experience. With Master's degree, eight years of required experience and with PhD, two years of required experience.
Preferred: At least two years of relevant experience in neuroimmunology and drug discovery research in biotech or pharmaceutical.
This position requires a highly self-motivated individual with outstanding organizational skills, the ability to effectively present results and conclusions to co-workers, collaborators and manager. Ability to work well under pressure and drive personal and team objectives that impact critical timelines is expected. A collaborative attitude is essential for this position.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Pivotal Position
Yes
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Additional Info:
[Click Here to Access the Original Job Post]