Job Description:
Investigate signaling pathways of importance to human disease. Project 1: The caspase-11 non-canonical inflammasome plays a significant role in host defense against Gram-negative bacteria including Escherichia coli, Citrobacter rodentium, Salmonella typhimurium, and Shigella flexneri. Intracellular lipopolysaccharide (LPS) activates caspase-11 causing pyroptotic cell death, IL-1b secretion, and lethal septic shock. We recently identified Gasdermin D (Gsdmd) as an essential executor of pyroptotic cell death. The intern’s project will focus on the mechanism of Gsdmd activation through biochemical and genetic approaches. Project 2: Interested in gene regulation, embryonic development and keen to apply machine learning methods? Our group is studying a pathway that is essential to embryonic development and yet not well understood. We have genome-scale RNA-seq for wild-type and cells with a key component of the pathway knocked out already in hand and a large RNA-seq time-course experiment is underway. The goal of this internship will be to use these data to improve our understanding of the pathway and how it relates to embryonic development. These problems are open ended with opportunities to use machine learning to delve deeper and consider additional related datasets. Target Start Date: Summer 2017 Who You Are: To be successful in this role, you will be or you will have: Project 1:Immunology experience Project 2: -Bioinformatics/Computational Biology/Biostatistics PhD student -Experienced programming for bioinformatics analysis, ideally in R -Experience analyzing time-course data (preferred) -Experience using machine learning methods (preferred)
Additional Info:
Who We Are: A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work. Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. [Click Here to Access the Original Job Post]
Investigate signaling pathways of importance to human disease. Project 1: The caspase-11 non-canonical inflammasome plays a significant role in host defense against Gram-negative bacteria including Escherichia coli, Citrobacter rodentium, Salmonella typhimurium, and Shigella flexneri. Intracellular lipopolysaccharide (LPS) activates caspase-11 causing pyroptotic cell death, IL-1b secretion, and lethal septic shock. We recently identified Gasdermin D (Gsdmd) as an essential executor of pyroptotic cell death. The intern’s project will focus on the mechanism of Gsdmd activation through biochemical and genetic approaches. Project 2: Interested in gene regulation, embryonic development and keen to apply machine learning methods? Our group is studying a pathway that is essential to embryonic development and yet not well understood. We have genome-scale RNA-seq for wild-type and cells with a key component of the pathway knocked out already in hand and a large RNA-seq time-course experiment is underway. The goal of this internship will be to use these data to improve our understanding of the pathway and how it relates to embryonic development. These problems are open ended with opportunities to use machine learning to delve deeper and consider additional related datasets. Target Start Date: Summer 2017 Who You Are: To be successful in this role, you will be or you will have: Project 1:Immunology experience Project 2: -Bioinformatics/Computational Biology/Biostatistics PhD student -Experienced programming for bioinformatics analysis, ideally in R -Experience analyzing time-course data (preferred) -Experience using machine learning methods (preferred)
Requeriments :
Skills :
Areas :
Additional Info:
Who We Are: A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work. Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. [Click Here to Access the Original Job Post]