Job ID: 5866
Job date: 2016-08-17
End Date:
Company : GlaxoSmithKline Country : Role : Research Scientist
Job date: 2016-08-17
End Date:
Company : GlaxoSmithKline Country : Role : Research Scientist
Job Description:
Basic qualifications:
A Ph.D. in molecular biology, chemistry, biochemistry or related discipline, plus 5+ years of post-graduate experience in an academic, clinical or industry research environment, with a record of leading innovative research as evidenced by an excellent publication record in peer reviewed journals (required)
Broad experience in advanced molecular biology techniques (required)
Knowledge and experience with NGS and other genomic and transcriptomic assay technologies (essential)
Extensive people and project/matrix team leadership experience, with demonstrated ability to work effectively across disciplines and within multidisciplinary teams (essential)
Bioinformatics knowledge and experience (essential)
Experience in the identification and validation of biomarkers of disease progression and drug response to support drug discovery and development (preferred)
Experience with various genome editing technologies in mammalian cells (preferred)
Knowledge/Skills/Abilities:
Preferred qualifications:
High-performance individual with a proven ability to generate results
Ability to successfully work in a team environment and to adapt to rapidly evolving needs
Ability to lead projects and interdisciplinary teams
Demonstrated ability to design experiments, solve problems independently, troubleshoot protocols, implement studies, analyze and interpret data, present results and maintain experimental records
Strong written and oral communication skills
Details:
GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.
An exciting opportunity is available at our main US-based R&D site (Upper Providence, PA) to lead a small team of scientists with a strong focus on genetics, genomics, transcriptomics, molecular and cellular biology, to help drive drug discovery research programs from conception to the clinic. Target Sciences is leveraging human genetic data and state-of-the-art molecular biology techniques in order to discover and validate novel therapeutic targets and pathways. The aim is to build strong evidence linking targets to disease during early stage drug discovery, in order to improve the probability of success of late stage clinical trials. We are looking for someone with broad experience in functional genomics, with specific expertise in cDNA cloning, expression construct engineering, gene knockdown (siRNA/shRNA), over-expression and genome editing (CRISPR/Cas9) in mammalian cells. Additional experience in related genomic technologies (next generation sequencing/NGS, transcriptomics) would be an advantage.
We are seeking an innovative and dynamic scientist to work in the Department of Target and Pathway Validation (TPV) within Target Sciences, in a multidisciplinary, collaborative environment interacting with other molecular and cellular biologists, computational biologists, geneticists, statisticians, and therapeutic area experts (e.g. Oncology, Metabolic Disease, Infectious Disease, Respiratory Disease) across R&D, as well as with external collaborators and key strategic alliance partners. The successful candidate will report directly to the current head of TPV-Experimental Genomics. Excellent communication, organization and presentation skills are required, as well as a demonstrated ability to work effectively in multidisciplinary teams.
Lead a small team of scientists exploring the functions of human genes and gene variants (SNPs) in multiple disease areas, by designing, engineering and utilizing custom recombinant reagents for target and pathway validation studies (gene knockdown, over-expression, genome editing) in relevant cellular models
Drive innovation to expand genomic research capabilities; investigate the complex relationship between genotype and phenotype in collaboration with internal experts in NGS and transcriptomics technology, utilizing a range of advanced techniques (RNA-seq, ATAC-seq, 3C-seq) to study gene transcription, translation, epigenetic regulation and the effect of chromatin structure/genomic interactions on gene expression
Work with other GSK scientists including disease experts to design experiments, analyze and interpret data, with the aim of identifying and validating new drug targets, and where appropriate, supporting subsequent target and molecule progression (e.g. compound mechanism of action, biomarker discovery and validation)
Collaborate with the external scientific community and with GSK strategic alliance partners (e.g. The Altius Institute for Biomedical Sciences, Seattle, WA; Open Targets, Cambridge, UK)
Help identify and champion new drug targets, lead research projects, manage resources, and deliver high quality scientific data with decision-making impact on program objectives and milestones
Contact information:
You may apply for this position online by selecting the Apply now button.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK HR Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).
GSK is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting For the Record site.
Additional Info:
[Click Here to Access the Original Job Post]
Basic qualifications:
A Ph.D. in molecular biology, chemistry, biochemistry or related discipline, plus 5+ years of post-graduate experience in an academic, clinical or industry research environment, with a record of leading innovative research as evidenced by an excellent publication record in peer reviewed journals (required)
Broad experience in advanced molecular biology techniques (required)
Knowledge and experience with NGS and other genomic and transcriptomic assay technologies (essential)
Extensive people and project/matrix team leadership experience, with demonstrated ability to work effectively across disciplines and within multidisciplinary teams (essential)
Bioinformatics knowledge and experience (essential)
Experience in the identification and validation of biomarkers of disease progression and drug response to support drug discovery and development (preferred)
Experience with various genome editing technologies in mammalian cells (preferred)
Knowledge/Skills/Abilities:
Preferred qualifications:
High-performance individual with a proven ability to generate results
Ability to successfully work in a team environment and to adapt to rapidly evolving needs
Ability to lead projects and interdisciplinary teams
Demonstrated ability to design experiments, solve problems independently, troubleshoot protocols, implement studies, analyze and interpret data, present results and maintain experimental records
Strong written and oral communication skills
Details:
GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.
An exciting opportunity is available at our main US-based R&D site (Upper Providence, PA) to lead a small team of scientists with a strong focus on genetics, genomics, transcriptomics, molecular and cellular biology, to help drive drug discovery research programs from conception to the clinic. Target Sciences is leveraging human genetic data and state-of-the-art molecular biology techniques in order to discover and validate novel therapeutic targets and pathways. The aim is to build strong evidence linking targets to disease during early stage drug discovery, in order to improve the probability of success of late stage clinical trials. We are looking for someone with broad experience in functional genomics, with specific expertise in cDNA cloning, expression construct engineering, gene knockdown (siRNA/shRNA), over-expression and genome editing (CRISPR/Cas9) in mammalian cells. Additional experience in related genomic technologies (next generation sequencing/NGS, transcriptomics) would be an advantage.
We are seeking an innovative and dynamic scientist to work in the Department of Target and Pathway Validation (TPV) within Target Sciences, in a multidisciplinary, collaborative environment interacting with other molecular and cellular biologists, computational biologists, geneticists, statisticians, and therapeutic area experts (e.g. Oncology, Metabolic Disease, Infectious Disease, Respiratory Disease) across R&D, as well as with external collaborators and key strategic alliance partners. The successful candidate will report directly to the current head of TPV-Experimental Genomics. Excellent communication, organization and presentation skills are required, as well as a demonstrated ability to work effectively in multidisciplinary teams.
Lead a small team of scientists exploring the functions of human genes and gene variants (SNPs) in multiple disease areas, by designing, engineering and utilizing custom recombinant reagents for target and pathway validation studies (gene knockdown, over-expression, genome editing) in relevant cellular models
Drive innovation to expand genomic research capabilities; investigate the complex relationship between genotype and phenotype in collaboration with internal experts in NGS and transcriptomics technology, utilizing a range of advanced techniques (RNA-seq, ATAC-seq, 3C-seq) to study gene transcription, translation, epigenetic regulation and the effect of chromatin structure/genomic interactions on gene expression
Work with other GSK scientists including disease experts to design experiments, analyze and interpret data, with the aim of identifying and validating new drug targets, and where appropriate, supporting subsequent target and molecule progression (e.g. compound mechanism of action, biomarker discovery and validation)
Collaborate with the external scientific community and with GSK strategic alliance partners (e.g. The Altius Institute for Biomedical Sciences, Seattle, WA; Open Targets, Cambridge, UK)
Help identify and champion new drug targets, lead research projects, manage resources, and deliver high quality scientific data with decision-making impact on program objectives and milestones
Contact information:
You may apply for this position online by selecting the Apply now button.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK HR Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).
GSK is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting For the Record site.
Requeriments :
Skills :
Areas :
Additional Info:
[Click Here to Access the Original Job Post]