Job ID: 5680
Job date: 2016-06-30
End Date:
Company : Bristol-Myers Squibb Country : Role : Postdoc | Research Scientist
Job date: 2016-06-30
End Date:
Company : Bristol-Myers Squibb Country : Role : Postdoc | Research Scientist
Job Description:
The BMS Clinical Genetics and Genomics Group is seeking a NGS Research Scientist to lead the development, validation, implementation, and growth of Next Generation Sequencing (NGS) technology to support the company’s pipeline across all active therapeutic areas with an emphasis on Oncology and Immunoscience. The group is responsible for the application of relevant technologies to measure specific genetic or genomic endpoints in clinical studies which support 1) mechanism of action hypotheses, 2) pharmacokinetic/pharmacodynamic evaluations, and 3) patient stratification or 4) novel biomarkers related to clinical response. He/She will liaise closely with the NGS core laboratories in the Discovery organization to ensure implementation of the appropriate genetic and genomic assays in early clinical studies (single genes, panels, etc) based on results of biomarker discovery efforts in those functions.Job duties: Drives the implementation and growth of NGS technology, supports ongoing development, validation and troubleshooting of NGS assays, including targeted DNA-seq and RNA-seq, WES, and WGS.Oversees operations of different NGS workflows; from sample preparation, library construction, data generation, data processing to interpretation of results, ensuring a high level of quality and reliability of generated results.Implements data processing and analysis workflows, bioinformatics pipelines, and data storage procedures in collaboration with internal and external multidisciplinary teams.Effectively manages available resources, distributes assignments and delegates workload as needed to achieve timely execution of projects, works with cross functional teams (internal and external teams) to execute plans and set deliverables.Serves as a subject matter expert for NGS technology, provides guidance on experimental design, method or platform selection, and data management to address a specific need.Educates laboratory staff and/or contractors, conducts hands-on training, and delivers internal and external presentations.Learns various NGS platforms, stays on the top of the scientific and technical innovations, and follows new trends and developments in genomic technologies to uphold BMS’s competitive advantage.Drafts experimental plans, validation reports, work instructions, technology transfer documents, study summaries and SOPs.Actively participates in internal/external collaborations, portfolio management groups and clinical study and biomarker execution teams. Qualifications The candidate must have a PhD (with a minimum of 2+ years of postdoctoral experience), or MS (with a minimum of 6+ years of experience) in a relevant scientific field, such as molecular biology, genetics and genomics, biochemistry, or other related disciplines, ideally in a pharmaceutical, biotech or clinical diagnostics industry.
Must have at least 2 years of documented hands-on (wet lab) experience with NGS assay development, validation, troubleshooting, and reviewing of run QC data.
Must have an in-depth knowledge of different NGS platforms and technologies (experience with long reads sequencing is a plus).
Must be familiar with different NGS software platforms, bioinformatics pipelines and NGS data processing and interpretation solutions.
Bioinformatics skills, programing in different languages, experience with command line, and familiarity with statistical software packages are highly desired.
Technical expertise with other molecular technologies, including but not limited to: PCR, quantitative real-time PCR, digital PCR, NanoString, etc. is also highly desired.
Must have strong organizational and interpersonal skills, must display excellent leadership and people skills, and demonstrate ability to work collaboratively with others in a highly matrixed environment.
Must be self-motivated, with a demonstrated ability to work independently and learn quickly.
Must be goal oriented and focused on completing work on time.
Must be able to quickly adapt to changing priorities and work well in fast pace environment and under pressure.
Must possess good communication and presentation skills. Bristol-Myers Squibb is an equal opportunity employer - Vet/Disability - 1506760
Additional Info:
[Click Here to Access the Original Job Post]
The BMS Clinical Genetics and Genomics Group is seeking a NGS Research Scientist to lead the development, validation, implementation, and growth of Next Generation Sequencing (NGS) technology to support the company’s pipeline across all active therapeutic areas with an emphasis on Oncology and Immunoscience. The group is responsible for the application of relevant technologies to measure specific genetic or genomic endpoints in clinical studies which support 1) mechanism of action hypotheses, 2) pharmacokinetic/pharmacodynamic evaluations, and 3) patient stratification or 4) novel biomarkers related to clinical response. He/She will liaise closely with the NGS core laboratories in the Discovery organization to ensure implementation of the appropriate genetic and genomic assays in early clinical studies (single genes, panels, etc) based on results of biomarker discovery efforts in those functions.Job duties: Drives the implementation and growth of NGS technology, supports ongoing development, validation and troubleshooting of NGS assays, including targeted DNA-seq and RNA-seq, WES, and WGS.Oversees operations of different NGS workflows; from sample preparation, library construction, data generation, data processing to interpretation of results, ensuring a high level of quality and reliability of generated results.Implements data processing and analysis workflows, bioinformatics pipelines, and data storage procedures in collaboration with internal and external multidisciplinary teams.Effectively manages available resources, distributes assignments and delegates workload as needed to achieve timely execution of projects, works with cross functional teams (internal and external teams) to execute plans and set deliverables.Serves as a subject matter expert for NGS technology, provides guidance on experimental design, method or platform selection, and data management to address a specific need.Educates laboratory staff and/or contractors, conducts hands-on training, and delivers internal and external presentations.Learns various NGS platforms, stays on the top of the scientific and technical innovations, and follows new trends and developments in genomic technologies to uphold BMS’s competitive advantage.Drafts experimental plans, validation reports, work instructions, technology transfer documents, study summaries and SOPs.Actively participates in internal/external collaborations, portfolio management groups and clinical study and biomarker execution teams. Qualifications The candidate must have a PhD (with a minimum of 2+ years of postdoctoral experience), or MS (with a minimum of 6+ years of experience) in a relevant scientific field, such as molecular biology, genetics and genomics, biochemistry, or other related disciplines, ideally in a pharmaceutical, biotech or clinical diagnostics industry.
Must have at least 2 years of documented hands-on (wet lab) experience with NGS assay development, validation, troubleshooting, and reviewing of run QC data.
Must have an in-depth knowledge of different NGS platforms and technologies (experience with long reads sequencing is a plus).
Must be familiar with different NGS software platforms, bioinformatics pipelines and NGS data processing and interpretation solutions.
Bioinformatics skills, programing in different languages, experience with command line, and familiarity with statistical software packages are highly desired.
Technical expertise with other molecular technologies, including but not limited to: PCR, quantitative real-time PCR, digital PCR, NanoString, etc. is also highly desired.
Must have strong organizational and interpersonal skills, must display excellent leadership and people skills, and demonstrate ability to work collaboratively with others in a highly matrixed environment.
Must be self-motivated, with a demonstrated ability to work independently and learn quickly.
Must be goal oriented and focused on completing work on time.
Must be able to quickly adapt to changing priorities and work well in fast pace environment and under pressure.
Must possess good communication and presentation skills. Bristol-Myers Squibb is an equal opportunity employer - Vet/Disability - 1506760
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Additional Info:
[Click Here to Access the Original Job Post]