PhD Scholarship in Genomics and Systems Biology

Job ID:
Job date: 2014-11-06
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Company : University of Copenhagen 

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Role : Student 


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Job Description:

The Department of Veterinary Clinical and Animal Sciences, Animal Breeding, Quantitative Genetics and Systems Biology (AQS) Group, is offering a PhD Scholarship to commence as soon as possible or after 1 January 2015. The position is limited to 3 years.

Information about the group can be found at www.qsg.dk, about the department at http://ikvh.ku.dk/english/, and about the faculty at: http://healthsciences.ku.dk/home/.

Project description
Boar taint (BT) in pigs has received greater attention in Europe recently because of the animal welfare issues related to surgical castration of piglets to avoid boar taint. Our group has been and is leading the research on genomics and systems biology of boar taint in Denmark through GBOAT and AGES projects. In the newly funded TRANSMEAT project, we aim to unravel common or different underlying (systems) biological mechanisms that generate boar taint as well as affect sensory meat quality (SMQ) in pigs. This project involves a large cross-breeding experiment resulting in high and low genetic merit BT pigs reared on different diets (known to reduce BT) over a period of time. Molecular relationship between BT and SMQ will be studied at genomic and transcriptomic levels with aims to detect biomarkers for SMQ and BT. Practical objective is to include them in rapid detection methods for BT and SMQ. This project is funded by the Green Development and Demonstration Programme (GUDP) of the Danish Ministry of Food, Agriculture and Fisheries for 4 years from January 1, 2014 until December 31, 2017. This public institution–private company partnership project comprise of teams from the University of Copenhagen, Danish Meat Research Institute, Pig Research Center of The Danish Agriculture & Food Council, Danish Crown and TICAN.

Job description
The candidate will primarily focus on:
•Involved in cross-breeding and genotype-by-nutrition pig experiment for boar taint
•Biological sample collection at the research farm and slaughter house
•Bioinformatics and systems biology analysis of transcriptomic data sets from several pig tissues based on paired-end RNAseq technology to detect differentially expressed and co-expressed genes and networks for boar taint and sensory meat quality traits
• GWAS (Genome-Wide Association Studies)using 60k genomic (porcine SNPchip) data
•Combined RNAseq and 60k SNPchip analyses to map eQTLs (expression quantitative trait loci) and to detect causative loci and predictive biomarkers
•Gene set enrichment, GO and Pathway profiling analyses
•Publications in peer-reviewed international journals

Required qualifications
•A Master of Science (MSc) with a major in animal science or biological or biotechnological sciences with thesis or focus in one or more of the following: animal bioinformatics or animal genomics or animal systems biology
•Prior demonstrated experience in using methods and tools of bioinformatics or quantitative genetics or systems biology
•Prior experience in processing and analysing microarray gene expression or RNAseq data and SNPchip genomic data with a focus to find biomarkers or networks for quantitative traits
•Knowledge in livestock production
•Motivation, dedication and excellent scientific skills are essential
•Ability to publish peer-reviewed journal articles internationally
•Very good command of English, written and oral
•Enterprising and possess good interpersonal skills

It is a perquisite that the PhD candidate is enrolled as PhD student at the Faculty of Health and Medical Sciences, University of Copenhagen, according to the rules stipulated in “Bekendtgørelse nr. 18 af 14. januar 2008 om ph.d.-graden.“

Terms of employment
The positions are available for a 3-year period for applicants holding a relevant master’s degree or for a 4-year period for applicants who are already enrolled or are accepted to be enrolled at one of the Faculty’s master’s programmes.

At the time of commencement, applicants for the 4-year period must have approximately one year of study remaining before graduating from their MSc programme.

Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organisations. The position is covered by the Job Structure for Academic Staff at Universities (2013).

Questions
For further scientific information, contact Professor Haja Kadarmideen, Leader of Animal Breeding, Quantitative Genetics and Systems Biology Group, e-mail: hajak@sund.ku.dk, phone: +45 353 33577.

For further application procedure and formalities, please contact: AQS group project coordinator, Gilda Kischinovsky, email: gk@sund.ku.dk or Department’s Administrative Officer, Marie-Louise Rosenlund, email: mlr@sund.ku.dk, phone: +45 353 32898.

Foreign applicants may find the following links useful: www.ism.ku.dk (International Staff Mobility) and www.workingconditions.ku.dk.

Application
The application must be submitted in English and must include the following:
•Cover Letter detailing your motivation and background for applying for the specific PhD project.
•CV
•Diploma and transcripts of records
•Other information for consideration, e.g. list of publications (if any), peer reviewed and other
•Personal Recommendations (if any)
•A maximum of 3 relevant scientific works which the applicant wishes to be included in the assessment.

The application will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

The University of Copenhagen encourages all interested in this post to apply.

Please submit the application with the required attachments by clicking on “Apply online” Only online applications will be accepted. The closing date for applications is 23.59pm, 5 December 2014. …


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