Job date: 2016-05-20
End Date:
Company : Icahn School of Medicine at Mount Sinai Country : Role : Postdoc
PostDoc/Scientist: Epigenomics and Transcriptomics of Human Diseases
Themes: Epigenomics (special focus on underexplored and new types of epigenetic variations), Transcriptomics, Integrate Single Molecule Sequencing (PacBio, Oxford Nanopore) + Illumina, Systems Biology of Human Diseases
Job description and Our Unique Expertise: Postdoc fellow and Senior Scientist positions at the Mount Sinai School of Medicine (Top-20 medical school in the US) in New York City. Our lab is in the Department of Genetics and Genomic Sciences and the Institute for Genomics and Multi-scale Biology. Our lab (80% computation + 20% experimental) pioneered the fast growing field of bacterial epigenomics with different forms of DNA methylations (e.g. 6mA, 4mC) beyond 5mC (the one extensively studied in human). Recent work by us and others discovered that not only does 6mA exists in eukaryotes including human, but it also has significant functional roles. A major focus of our lab is to explore this young and promising field of 6mA epigenomes, discover other novel types of DNA modifications, their relationship to well-studied DNA/histone modifications, and make fundamentally new discoveries about human diseases: infectious diseases, cancers and mental disorders. We have unique expertise in the use of third generation sequencing (single molecule real-time, ~20kbp read length, and the emerging nanopore technique) with advantages of detecting different types of DNA modifications, single molecule-level epigenetic phasing, full-length transcript isoforms, complex structural variations. Successful candidates will have unique opportunities to i) build on our unique expertise, large scale collection of clinically relevant samples and a strong network of collaborators, ii) take the lead role in multiple projects on the innovative use of third-generation sequencing and systems biology to pioneer the mapping and characterization of novel forms of DNA methylations in eukaryotic genomes for both basic biology and clinical applications. Compensations for successful candidates are highly competitive. Subsidized housing (in New York City) is also available.
Recent publications: * Cell Reports, 2016 * Nature, 2016 * Nature Communications, 2015 * PLoS Genetics, 2015 * Biological Psychiatry, 2015 * Nature Communications, 2014 * Molecular Psychiatry, 2014 * PLoS Genetics, 2013 * PLoS Computational Biology, 2013 * Nature Biotechnology, 2012 * Genome Research, 2012
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