Job ID: 606987
Job date: 2017-03-07
End Date:
Company : Wellcome Trust Sanger Institute Country : Role : Postdoc
Job date: 2017-03-07
End Date:
Company : Wellcome Trust Sanger Institute Country : Role : Postdoc
Job Description:
Postdoctoral Fellow – neurobiology and bioinformatics Salary £31,115 to £39,004 plus excellent benefits. Fixed term for 2 years. The Wellcome Trust Sanger Institute conducts cutting edge genomic research and the focus of our group is to develop new methods and models that will further our understanding of gene expression and gene regulation. We are looking for a dynamic and motivated Postdoctoral Fellow to join the Hemberg Faculty Team and undertake research into neurobiology and bioinformatics. The successful candidate will be expected to contribute to the formulation and submission of research publications and research proposals as well as help manage and direct this complex and challenging project, as opportunities allow. The primary goal of this position is to be involved in the Open Targets funded study of human neuronal cultures derived from patients with familial Alzheimer’s disease (AD) mutations using single-cell RNA-seq (scRNA-seq). The main goal is to characterize and compare different cell-types for mutants and controls to identify the pathways that result in early onset AD. This will require using established pipelines and software for analysing scRNA-seq data, as well as developing novel methods for identifying differentially expressed genes and inferring gene regulatory networks. The project is a collaboration with the Livesey and Teichmann labs, and an important aspect of this role will be to interact with members of those groups for the analysis and interpretation of the data. Essential Skills
Additional Info:
The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. [Click Here to Access the Original Job Post]
Postdoctoral Fellow – neurobiology and bioinformatics Salary £31,115 to £39,004 plus excellent benefits. Fixed term for 2 years. The Wellcome Trust Sanger Institute conducts cutting edge genomic research and the focus of our group is to develop new methods and models that will further our understanding of gene expression and gene regulation. We are looking for a dynamic and motivated Postdoctoral Fellow to join the Hemberg Faculty Team and undertake research into neurobiology and bioinformatics. The successful candidate will be expected to contribute to the formulation and submission of research publications and research proposals as well as help manage and direct this complex and challenging project, as opportunities allow. The primary goal of this position is to be involved in the Open Targets funded study of human neuronal cultures derived from patients with familial Alzheimer’s disease (AD) mutations using single-cell RNA-seq (scRNA-seq). The main goal is to characterize and compare different cell-types for mutants and controls to identify the pathways that result in early onset AD. This will require using established pipelines and software for analysing scRNA-seq data, as well as developing novel methods for identifying differentially expressed genes and inferring gene regulatory networks. The project is a collaboration with the Livesey and Teichmann labs, and an important aspect of this role will be to interact with members of those groups for the analysis and interpretation of the data. Essential Skills
- PhD (or equivalent) in Mathematics, Physics or Computer Science
- Ability to independently solve complex scientific/technical problems and manage scientific projects
- Excellent communication skills
- Self-motivation and diligence
- Ability to work with an international group of scientists
- Good publication track record
- Advanced bioinformatics skills in NGS data analysis
- Good understanding of genomics and molecular biology
- Strong programming skills
- Experience with single-cell genomics
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Additional Info:
The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. [Click Here to Access the Original Job Post]