Job Description:
Post-doctoral Position in Computational Biology
Deciphering the mechanisms of transcription and DNA repair using ChIP-Seq
A two-year postdoctoral position in computational biology is open at the Institute for Integrative Biology of the Cell (I2BC), Integrative Biology and Molecular Genetics Unit (SBIGeM) on the Saclay campus of the CEA. The position is open immediately and will be closed when a suitable candidate is found.
The position is funded by the Fondation ARC, to work in the group “Transcriptional Regulation of Genomes” headed by Dr Julie Soutourina on the central role of the Mediator complex in the mechanisms of transcription regulation and DNA repair. The project uses the yeast Saccharomyces cerevisiae and human cells as model systems.
The post-doctoral fellow will be in charge of an integrative analysis of a range of ChIP-Seq and other functional genomics data that offer an excellent opportunity to make an important contribution to our understanding of the basic mechanisms of transcription initiation. He/she should also have a true interest in the use, and possibly the development, of computational/statistical approaches for the analysis of these types of data.
Key steps of the work will for instance consists in:
classifying promoters based on of ChIP-Seq profiles across an array of experiments (~70) targeting several proteins in several mutant strains. estimating molecular turnover of protein binding along the genome from time course ChIP-Seq data.
He/she will work closely with the yeast molecular biologists of the lab and with computational biologists (Drs Pierre Nicolas and Vincent Fromion) of the “Mathematique Informatique et Génome” laboratory located in the nearby INRA campus of Jouy-en-Josas. Both teams have strong and complementary expertise in the analysis of high throughput data for functional genomics.
The laboratory is located southwest of Paris (France). Information can be found on the web sites of the team http://www-dsv.cea.fr/ibitecs/sbigem/lrege/transcription.
To submit your application for this position, please click on the "APPLY" button.
Desired skills and experience
The successful candidate will have a PhD in computational biology, applied mathematics, or molecular biology with background knowledge in computational biology and statistics. A prior experience in the analysis of high-throughput DNA sequencing data is strongly recommended.
About the employer
The CEA is the French Alternative Energies and Atomic Energy Commission (Commissariat à l'énergie atomique et aux énergies alternatives). It is a public body established in October 1945 by General de Gaulle. A leader in research, development and innovation, the CEA mission statement has two main objectives: To become the leading technological research organization in Europe and to ensure that the nuclear deterrent remains effective in the future.
The CEA is active in four main areas: low-carbon energies, defense and security, information technologies and health technologies. In each of these fields, the CEA maintains a cross-disciplinary culture of engineers and researchers, building on the synergies between fundamental and technological research.
Additional Info:
[Click Here to Access the Original Job Post]
Post-doctoral Position in Computational Biology
Deciphering the mechanisms of transcription and DNA repair using ChIP-Seq
A two-year postdoctoral position in computational biology is open at the Institute for Integrative Biology of the Cell (I2BC), Integrative Biology and Molecular Genetics Unit (SBIGeM) on the Saclay campus of the CEA. The position is open immediately and will be closed when a suitable candidate is found.
The position is funded by the Fondation ARC, to work in the group “Transcriptional Regulation of Genomes” headed by Dr Julie Soutourina on the central role of the Mediator complex in the mechanisms of transcription regulation and DNA repair. The project uses the yeast Saccharomyces cerevisiae and human cells as model systems.
The post-doctoral fellow will be in charge of an integrative analysis of a range of ChIP-Seq and other functional genomics data that offer an excellent opportunity to make an important contribution to our understanding of the basic mechanisms of transcription initiation. He/she should also have a true interest in the use, and possibly the development, of computational/statistical approaches for the analysis of these types of data.
Key steps of the work will for instance consists in:
classifying promoters based on of ChIP-Seq profiles across an array of experiments (~70) targeting several proteins in several mutant strains. estimating molecular turnover of protein binding along the genome from time course ChIP-Seq data.
He/she will work closely with the yeast molecular biologists of the lab and with computational biologists (Drs Pierre Nicolas and Vincent Fromion) of the “Mathematique Informatique et Génome” laboratory located in the nearby INRA campus of Jouy-en-Josas. Both teams have strong and complementary expertise in the analysis of high throughput data for functional genomics.
The laboratory is located southwest of Paris (France). Information can be found on the web sites of the team http://www-dsv.cea.fr/ibitecs/sbigem/lrege/transcription.
To submit your application for this position, please click on the "APPLY" button.
Desired skills and experience
The successful candidate will have a PhD in computational biology, applied mathematics, or molecular biology with background knowledge in computational biology and statistics. A prior experience in the analysis of high-throughput DNA sequencing data is strongly recommended.
About the employer
The CEA is the French Alternative Energies and Atomic Energy Commission (Commissariat à l'énergie atomique et aux énergies alternatives). It is a public body established in October 1945 by General de Gaulle. A leader in research, development and innovation, the CEA mission statement has two main objectives: To become the leading technological research organization in Europe and to ensure that the nuclear deterrent remains effective in the future.
The CEA is active in four main areas: low-carbon energies, defense and security, information technologies and health technologies. In each of these fields, the CEA maintains a cross-disciplinary culture of engineers and researchers, building on the synergies between fundamental and technological research.
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Additional Info:
[Click Here to Access the Original Job Post]