Job ID: HM2017064
Job date: 2017-04-28
End Date:
Company : Imperial College London Country : Role : Postdoc
Job date: 2017-04-28
End Date:
Company : Imperial College London Country : Role : Postdoc
Job Description:
We are looking for a talented, ambitious and highly skilled postdoctoral researcher with a background in gene regulation, promoter analysis, computational epigenomics or a related field. The candidate should have a strong publication record, indicating potential for independent high-impact research, as well as in-depth knowledge of molecular biology. Since this is a computational biology position, the candidate is expected to have proficiency in programming and analysis of genomics data. Applications from candidates with a molecular biology background who want to move to computational biology will be considered if accompanied by a strong letter of motivation and a desire to acquire the required knowledge. The post is funded by a Wellcome Trust Investigator award for the project entitled “Core promoter: an unexplored regulatory level of transcription during vertebrate development”. Its aim is to investigate the role of core promoters and their diverse architectures in vertebrate development and differentiation, and to devise approaches to study them in zebrafish as a model organism. It is based on a series of recent discoveries and methodological advances by the group, published in top journals including Nature, Genome Research, NAR, Bioinformatics and others. The computational tools to study these phenomena include software for the analysis of promoter and enhancer element, web-based resources for the integration and visualization of sequence and epigenetic experiments, and databases of expression patterns of regulatory elements tested in zebrafish. The work includes the analysis and participation in planning of collaborative experiments based on methods such as cap analysis of gene expression (CAGE), including novel single-locus CAGE, CRISPR/Cas9 and other planned derivatives, as well as the supporting ChIP-seq and reporter assays in developing embryos. Within the project there is ample opportunity for taking initiative and choosing one’s own direction, which will be strongly encouraged. The post is a unique opportunity to work on developing cutting-edge approaches in a rapidly growing field of research, in one of the leading research environments in Europe and the world. The post holder will have the opportunity to work with a worldwide network of collaborators, attend scientific conferences, and publish the results of their work in top journals. You should have a PhD in Computational Biology, Molecular Biology or a related discipline, and a publication record of high-quality papers, preferably as first author. Knowledge of molecular biology and genomics is expected, as well as general quantitative intuition and knowledge of statistics. Experience with programming and analysis of next generation sequencing data and applications of machine learning in genomics are a strong plus; alternatively, a strong desire to learn it in a short time, as well as evidence for the ability to do so, will be considered.
Additional Info:
Informal enquiries may be directed to Boris Lenhard at b.lenhard@imperial.ac.uk. Our preferred method of application is online via our website at http://www3.imperial.ac.uk/employment (please select “Job Search” then enter the job title or vacancy reference number into “Keywords”). Please complete and upload an application form as directed quoting reference number. Alternatively, if you are unable to apply online, please email Fern Whyte at f.whyte@imperial.ac.uk to request an application form. Committed to equality and valuing diversity. We are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.[Click Here to Access the Original Job Post]
We are looking for a talented, ambitious and highly skilled postdoctoral researcher with a background in gene regulation, promoter analysis, computational epigenomics or a related field. The candidate should have a strong publication record, indicating potential for independent high-impact research, as well as in-depth knowledge of molecular biology. Since this is a computational biology position, the candidate is expected to have proficiency in programming and analysis of genomics data. Applications from candidates with a molecular biology background who want to move to computational biology will be considered if accompanied by a strong letter of motivation and a desire to acquire the required knowledge. The post is funded by a Wellcome Trust Investigator award for the project entitled “Core promoter: an unexplored regulatory level of transcription during vertebrate development”. Its aim is to investigate the role of core promoters and their diverse architectures in vertebrate development and differentiation, and to devise approaches to study them in zebrafish as a model organism. It is based on a series of recent discoveries and methodological advances by the group, published in top journals including Nature, Genome Research, NAR, Bioinformatics and others. The computational tools to study these phenomena include software for the analysis of promoter and enhancer element, web-based resources for the integration and visualization of sequence and epigenetic experiments, and databases of expression patterns of regulatory elements tested in zebrafish. The work includes the analysis and participation in planning of collaborative experiments based on methods such as cap analysis of gene expression (CAGE), including novel single-locus CAGE, CRISPR/Cas9 and other planned derivatives, as well as the supporting ChIP-seq and reporter assays in developing embryos. Within the project there is ample opportunity for taking initiative and choosing one’s own direction, which will be strongly encouraged. The post is a unique opportunity to work on developing cutting-edge approaches in a rapidly growing field of research, in one of the leading research environments in Europe and the world. The post holder will have the opportunity to work with a worldwide network of collaborators, attend scientific conferences, and publish the results of their work in top journals. You should have a PhD in Computational Biology, Molecular Biology or a related discipline, and a publication record of high-quality papers, preferably as first author. Knowledge of molecular biology and genomics is expected, as well as general quantitative intuition and knowledge of statistics. Experience with programming and analysis of next generation sequencing data and applications of machine learning in genomics are a strong plus; alternatively, a strong desire to learn it in a short time, as well as evidence for the ability to do so, will be considered.
Requeriments :
Skills :
- Genetics
- genomic
- Machine Learning
- molecular biology
- Next Generation Sequencing
- Programing Skills
- Statistics
Areas :
Additional Info:
Informal enquiries may be directed to Boris Lenhard at b.lenhard@imperial.ac.uk. Our preferred method of application is online via our website at http://www3.imperial.ac.uk/employment (please select “Job Search” then enter the job title or vacancy reference number into “Keywords”). Please complete and upload an application form as directed quoting reference number. Alternatively, if you are unable to apply online, please email Fern Whyte at f.whyte@imperial.ac.uk to request an application form. Committed to equality and valuing diversity. We are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.[Click Here to Access the Original Job Post]