Job date: 2016-05-19
End Date:
Company : Medical Research Council Country : Role : Postdoc
Postdoctoral Scientist – Bioinformatics
MRC Toxicology Unit, Leicester
Fixed Term for 5 years
Salary £28,935 - £32,648
The Medical Research Council Toxicology Unit, (currently located at the University of Leicester but relocating to the University of Cambridge in 2018), is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. We are equipped with state-of-the-art facilities and provide a supportive and learning environment helping postdoctoral scientists to establish themselves as successful research scientists in their chosen field.
Applications are invited for a postdoctoral scientist/bioinformatician to carry out detailed bioinformatics analysis on large data sets generated from proteomic and transcriptomic studies on localised RNA binding proteins. You will join the post transcriptional control group, led by Professor Anne Willis to work on a project funded by a joint Wellcome Trust Investigator award to Professor Anne Willis and Professor Kathryn Lilley University of Cambridge. The project is entitled “Transcription, Trafficking, Translation: dissecting the spatiotemporal mechanisms underlying localised protein synthesis”.
It is now widely acknowledged that mRNA is spatially organised such that its translation frequently occurs in the vicinity where the corresponding protein product adopts its function. This phenomenon has been studied extensively in specialised cells, however, recent research has suggested that spatial restriction of mRNA storage and translation is much more widespread.
The aims of this project are to define where translation of mRNA takes place in the cell, how this is regulated by protein binding partners and sequence motifs and how this changes upon cellular perturbation.
For more information please visit: http://tox.mrc.ac.uk/research/willis-group/
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