The Position
We are seeking an exceptionally talented Principal Scientist/ Associate Director to lead the R&D Computational Biology effort. This individual will report to the VP of Bioinformatics. This is a hands-on role that will expand and maintain expertise in cutting-edge computing tools and leverage internal and external data sets to deepen our understanding in NGS technology, genetics, genomics, computational and systems biology. This effort will enhance our power in machine learning and data mining towards the diagnosis of important medical conditions. Together with colleagues, this individual will experience the implementation of their efforts towards a product that will impact patients in the clinic very quickly. This role will also be responsible for the continued development of novel analysis tools to efficiently utilize genomic and clinical data from a vast repository of patient samples as well as from publicly available sources.
Initial goals include:
Apply deep knowledge in genomics and sequencing technologies to help optimize the existing sequencing analysis pipeline to improve signal to noise and ensure that the most biologically relevant features have been captured and enhanced to best enable classificationDevelop methodologies and tools to extract, process, and combine the most relevant features from expression signals, DNA alterations (variants, SNPs, indels, fusions, LOH, copy number variation, etc), imaging (radiology, cytology, pathology), clinical information and demographic characteristics to reach high-performance classification of the desired clinical outcomeMaintain keen awareness of industry trends and evaluate applicability of new machine learning and deep learning methods and continuously expand our tool box to most efficiently utilize the data in hand necessary to develop the optimal diagnostic tools.Implement, evaluate and improve upon existing semi-supervised learning algorithms to maximally utilize internal sample usage and improve classification performanceWork closely with the R&D infrastructure lead to expand and streamline data extraction, processing and the downstream analysis process to support all disease indicationsProvide mentoring and guidance to team members on computational and systems biology, genomics, sequencing technology, computation and machine learning toolsWho You Are
The successful candidate should be motivated by the opportunity to contribute to the discovery and development of clinically vital diagnostic tests that dramatically improve patient outcome and quality of life. You should be a creative problem solver who loves working in a multidisciplinary team of statisticians, bioinformatics scientists, BioIT staff and wet lab biologists. This individual will focus specifically on computational biology with an emphasis on deep genomic sequencing analysis and machine learning within Research and Development with an emphasis on cross-disciplinary integrative data analytics and modeling. The incumbent will be familiar with emerging approaches for analyzing and modeling clinical, molecular and other complex data types. This includes traditional bioinformatics and systems biology methods as well as data mining and machine learning approaches. We are looking for a leader who can collaborate effectively across multiple domains internally and externally to drive our computational biology strategy forward.
Other key experiences and knowledge includes:
A Ph.D. degree in computer science, electrical engineering, computational biology, bioinformatics or equivalent with a minimum of 10 years applicable professional experience is necessary, with five of those years in an industry settingTechnical proficiency and experience in languages such as R, Matlab, Python, Java, JavaScript, and C++Deep knowledge in molecular biology and hands-on advanced proficiency in handling and analyzing large data sets such as next-generation sequencing data. Experience working with imaging data is a plus.Highly experienced with the information technology aspects of data collection, organization, and integration, as well as the systems and tools required for data processing, machine learning and analysisExpertise in dimensionality reduction techniquesHighly experienced in writing peer-reviewed scientific manuscripts, abstracts, technical reports, SOPs, design history files, protocols, analysis plans and best practice guidelines. Ability to translate complex statistical/informatics terminology in such a way that scientifically trained individuals can readily understand their significanceRelevant track record of molecular diagnostic product development processWhat We Can Offer You
Veracyte is a growing company that offers significant career opportunities if you are curious, driven, patient-oriented and aspire to help us build a great company. We work collaboratively across disciplines, offering you the opportunity to constantly learn from your colleagues and, together, to publish frequently. We offer conveniences including an on-site gym and free shuttle service from nearby BART and CalTrain stations. We are a company with heart and believe in positively impacting the world beyond our doors by providing our product to those who cannot afford it through a financial assistance program. Veracyte seeks the best employees and works to create an environment in which they can thrive, expanding their knowledge and skill set all while contributing at the highest level
Employment Type: Full-Time
Benefits Offered:
Medical InsuranceDental InsuranceVision Insurance401KLife InsuranceAbout Veracyte
Veracyte is pioneering molecular cytology; we are dedicated to helping people avoid unnecessary invasive procedures just to get a diagnosis and to reducing healthcare costs at the same time. We use rigorous science to unlock genomic answers from tiny numbers of cells obtained through minimally invasive methods before surgery is needed. We launched our first product the Afirma® Thyroid FNA Analysis, with a genomic test at its core in record time and have already helped save thousands of patients from unnecessary surgery due to ambiguous thyroid nodule biopsy results. Our genomic test is offered by hundreds of physicians around the country, is covered by Medicare and private payers, and is clinically validated, including in a multicenter study published in the New England Journal of Medicine. Earlier this year, we entered the pulmonology space with the launch of Percepta. The Percepta test uses advanced genomic technology to help patients avoid unnecessary invasive, risky procedures on suspicious lung nodules or lesions that were initially found on computed tomography (CT) scans. Percepta is clinically validated, with its key studies recently published in the New England Journal of Medicine. Looking to our pulmonology pipeline, we are also developing a product to target idiopathic pulmonary fibrosis.
The Wall Street Journal named us to its list of top-50 venture capital-funded companies in 2011, BayBio honored us with its Fast Start award in 2012, and In Vivo: The Business and Medicine Report featured us recently as a model for how to build a molecular cytology company. In 2014 and 2015 our employees voted us a Bay Area News Group Top Workplace.
Veracyte affords equal employment opportunities to all qualified persons, regardless of race, color, religion, national origin, age, sex, disability, sexual orientation, gender expression, veteran or marital status. Veracyte participates in E-Verify in the United States
Job Type: Full-time
Local candidates only:
South San Francisco, CA 94080Required experience:
Applicable professional experience is necessary, with five of those years in an industry setting: 10 yearsRequired education:
DoctorateSkills :
- Bioinformatics
- Biology
- Computational Biology
- Genetics
- Machine Learning
- Modeling
- Next Generation Sequencing
- Programing in C++
- Programing in Python
- Programming in Java
- Programming in Matlab
- Programming in R
- Systems Biology
Areas :
Additional Info:
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