Job ID:
Job date: 2018-05-01
End Date: 2018-06-30
Company : Celgene Corporation Country : United States Role : Research Scientist
Job date: 2018-05-01
End Date: 2018-06-30
Company : Celgene Corporation Country : United States Role : Research Scientist
Job Description:
We seek an experienced and innovative bioinformatics scientist to join our Research Analytics team in San Diego. Research Analytics is a globally-distributed team within Celgene’s Research Informatics and Knowledge Utilization (RIKU) department, involved in collaborative bioinformatics, computational biology and patient selection research alongside colleagues in the Celgene Research & Early Development (R/ED) organization. Research Analytics members work across R/ED centers of excellence in Protein Homeostasis, Immuno-Oncology, Immuno-Inflammation & Epigenetics, functional areas including biotherapeutics development and pharmacology, and across early discovery and translational research programs. This role focuses on leading-edge bioinformatics approaches to enable our newly-formed Next Generation Sequencing (NGS) research capability in San Diego. The successful candidate will be responsible for development and application of NGS data processing, analysis and visualization approaches across a broad range of NGS profiling protocols, including single-cell platforms, and application scenarios. This individual will play a key scientific role enabling innovative computational analysis strategies across a wide range of data sources to empower data-driven decisions and improve therapeutic outcomes in complex diseases of unmet medical need. Expertise in the analysis of large genomic datasets, and contemporary methods for processing, analysis and integration of NGS data are prerequisite. Individuals with exceptional NGS bioinformatics, communication and collaboration skills are preferred. The role suits applicants with strong leadership potential, with prior experience of research supervision. Working alongside computational, biology and clinical researchers across the Celgene Research and Early Development organization, responsibilities include but are not limited to:
Additional Info:
Other Locations:US- CA- San Diego Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture. #LI-POST BIO-US Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.[Click Here to Access the Original Job Post]
We seek an experienced and innovative bioinformatics scientist to join our Research Analytics team in San Diego. Research Analytics is a globally-distributed team within Celgene’s Research Informatics and Knowledge Utilization (RIKU) department, involved in collaborative bioinformatics, computational biology and patient selection research alongside colleagues in the Celgene Research & Early Development (R/ED) organization. Research Analytics members work across R/ED centers of excellence in Protein Homeostasis, Immuno-Oncology, Immuno-Inflammation & Epigenetics, functional areas including biotherapeutics development and pharmacology, and across early discovery and translational research programs. This role focuses on leading-edge bioinformatics approaches to enable our newly-formed Next Generation Sequencing (NGS) research capability in San Diego. The successful candidate will be responsible for development and application of NGS data processing, analysis and visualization approaches across a broad range of NGS profiling protocols, including single-cell platforms, and application scenarios. This individual will play a key scientific role enabling innovative computational analysis strategies across a wide range of data sources to empower data-driven decisions and improve therapeutic outcomes in complex diseases of unmet medical need. Expertise in the analysis of large genomic datasets, and contemporary methods for processing, analysis and integration of NGS data are prerequisite. Individuals with exceptional NGS bioinformatics, communication and collaboration skills are preferred. The role suits applicants with strong leadership potential, with prior experience of research supervision. Working alongside computational, biology and clinical researchers across the Celgene Research and Early Development organization, responsibilities include but are not limited to:
- Pursue leading applied computational genomics approaches aligned with key Celgene scientific objectives and the activities of our internal NGS research capability.
- Line-manage and provide onsite supervision of junior bioinformatics researchers working in related areas.
- Apply contemporary methods for genomic data processing, analysis and mining. Develop and maintain NGS data processing and visualization pipelines, with focus on application of novel methodologies drawn from the literature and/or in-house research efforts.
- Partner with colleagues in the design and pursuit of NGS experiments that maximize the depth and robustness of insight drawn from the resulting datasets.
- Provide written documentation and specifications for methods and workflows. Guide data specifications for external vendor interactions.
- Perform comparative algorithmic, platform and vendor assessments and contribute to research into novel sequencing protocols.
- Present and report methods, results and conclusions to a publishable standard.
- Ph.D. in bioinformatics, computational biology, genetics, computer science or related discipline at a recognized higher-education establishment.
- 8+ years relevant post-doctoral experience of inter-disciplinary bioinformatics research, in academic or industry research scenarios.
- Publication record in analysis and development of methods for next-generation sequencing data (e.g. RNA-seq, WES, WGS, ChIP-Seq, Single-cell profiling, etc.).
- Expert knowledge of current bioinformatics trends, public genomic tools, databases and utilities, with a focus on Next Generation Sequencing and genome annotation.
- Familiarity with public NGS processing and analysis pipelines for bulk and single cell datasets, SNV and SV calling algorithm, common NGS manipulation tools and standardized NGS data formats (e.g. SAM/BAM, VCF)
- Good knowledge of molecular biology, genetics, and genomics with expert understanding of molecular profiling technologies.
- Experience in the analysis and interpretation of epigenetic and single-cell profiling datasets.
- Expert in Linux, with working knowledge of Windows/MacOS. Excellent programming skills using scripting languages (e.g. Perl, Python, R/Bioconductor, Shiny, PHP, Matlab).
- Good knowledge of contemporary database structures. Experience with SQL and noSQL databases would be advantageous. Experience of working with contemporary LIMS systems desirable.
- Experience with high performance computing, including cloud computing (AWS), cloud HPC, Docker and team collaboration software.
- Experience developing and integrating data analysis tools to manipulate large datasets.
- Motivated, innovative and strong team player able to function with a high degree of independence. Demonstrable ability for deep and creative thinking.
- Excellent time management and organizational skills.
- Excellent verbal and written communication skills. Fluent verbal and written English language skills prerequisite.
Requeriments :
Skills :
- Bioinformatics
- Bioinformatics Databases
- Genetics
- genomic
- HPC
- LIMS
- Lunix/Unix
- molecular biology
- Next Generation Sequencing
- NoSQL
- PHP
- Programing in Python
- Programing Skills
- Programming in Matlab
- Programming in PERL
- Programming in R
- RNA-seq
- SQL
Areas :
Additional Info:
Other Locations:US- CA- San Diego Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture. #LI-POST BIO-US Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.[Click Here to Access the Original Job Post]