Job Description:
Mission Statement
AstraZeneca is a global, innovation-driven, integrated biopharmaceutical company. Our mission is to make a meaningful difference to patient health through great medicines that bring benefit for patients and add value for society. We discover, develop, manufacture and market prescription medicines for important areas of healthcare, which include some of the world's most serious illnesses: cancer, cardiovascular disease, infection, neuroscience, and respiratory, inflammation, and autoimmune diseases.
Job Description
We are currently recruiting a highly qualified computational chemist with significant pharmaceutical industry experience who will be joining our multidisciplinary oncology team. The successful candidate will support project teams from target identification through lead optimization and ultimately drug candidate selection. The candidate is expected to have a high degree of independence and proven track record of applying computational chemistry techniques to advance small-molecule drug discovery programs. The qualified candidate will be creative and detail-oriented with a passion for drug discovery.
The candidate will work collaboratively with medicinal chemists and project teams to design compounds with improved potency, selectivity, functional activity and/or ADME properties. In addition, the work will include coaching more junior scientists to analyze, interpret, and visualize biological data, and communicate these results. Being an active and challenging member of drug design teams by both representing high standards of the computational chemistry discipline and using broad insight into other disciplines will be a core part of this role. The role holder may function as the lead chemist of drug discovery projects, dependent on experience. Additionally, the role holder will be accountable for devising, championing or developing state of the art computational chemistry techniques that solve key problems for project and chemistry teams. The candidate will be expected to regularly publish high quality scientific papers with original results.
~bsp
Preferred requirements
A PhD in computational chemistry, biophysics, or a related field, with >6 years of relevant experience in a pharmaceutical drug discovery setting
Experience in structure-based drug design (e.g., docking and scoring, virtual screening, library design, homology modeling)
Experience with chemoinformatics and bioinformatics tools for database similarity searching, pharmacophore modeling, QSAR modeling, and identification and analysis of protein binding sites
Expert understanding of medicinal chemistry concepts and demonstrated success in addressing medicinal chemistry design challenges
A strong record of delivering portfolio success and driving projects through to the identification of high quality small-molecule drug candidates
Experience with in silico predictive methods for the improvement of physico-chemical and ADMET characteristics
Excellent awareness of current developments in computational chemistry and ability to identify opportunities to advance the science in this field
Experience with coaching and supporting junior computational and/or medicinal chemists
Strong programming/scripting capabilities (e.g., python, perl, OEChem toolkit, C++) desirable
Strong written and oral communication skills
Ability to work well in multi-disciplinary teams
Location
The position will be placed at AstraZeneca R&D Boston, USA
Visa Requirements
A valid visa for working in the US is required.
AstraZeneca offers a flexible environment and the kinds of benefits and rewards that boost morale, ease your mind, and allow you to concentrate on the things that matter most. It's no surprise to us that Astrazeneca wins awards for being a great place to work.
Working Mother Magazine's 100 Best Companies for Working Mothers, 2015 for the 14th consecutive year. Based on data gathered on the availability, usage and tracking of advancement programs, the representation of women, leave policies, benefits, child care, and more, AstraZeneca has been ranked as one of the top 100 best companies for working mothers again this year.
Top 50 Companies for Executive Women, NAFE, 2016 for the 8th consecutive year. The National Association for Female Executives (NAFE) recently named AstraZeneca as one of the top 50 companies for female executives for the sixth consecutive year.
Best Adoption-Friendly Workplaces in America, Dave Thomas Foundation for Adoption
Best Place to Work for LGBT Equality, Human Rights Campaign Foundation, 2015
Top 50 Companies for Diverse Managers, DiversityMBA Magazine
Visit astrazeneca.com for more information on the company's commitment to diversity and inclusion.
Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled/Sexual Orientation/Gender Identity
Additional Info:
[Click Here to Access the Original Job Post]
Mission Statement
AstraZeneca is a global, innovation-driven, integrated biopharmaceutical company. Our mission is to make a meaningful difference to patient health through great medicines that bring benefit for patients and add value for society. We discover, develop, manufacture and market prescription medicines for important areas of healthcare, which include some of the world's most serious illnesses: cancer, cardiovascular disease, infection, neuroscience, and respiratory, inflammation, and autoimmune diseases.
Job Description
We are currently recruiting a highly qualified computational chemist with significant pharmaceutical industry experience who will be joining our multidisciplinary oncology team. The successful candidate will support project teams from target identification through lead optimization and ultimately drug candidate selection. The candidate is expected to have a high degree of independence and proven track record of applying computational chemistry techniques to advance small-molecule drug discovery programs. The qualified candidate will be creative and detail-oriented with a passion for drug discovery.
The candidate will work collaboratively with medicinal chemists and project teams to design compounds with improved potency, selectivity, functional activity and/or ADME properties. In addition, the work will include coaching more junior scientists to analyze, interpret, and visualize biological data, and communicate these results. Being an active and challenging member of drug design teams by both representing high standards of the computational chemistry discipline and using broad insight into other disciplines will be a core part of this role. The role holder may function as the lead chemist of drug discovery projects, dependent on experience. Additionally, the role holder will be accountable for devising, championing or developing state of the art computational chemistry techniques that solve key problems for project and chemistry teams. The candidate will be expected to regularly publish high quality scientific papers with original results.
~bsp
Preferred requirements
A PhD in computational chemistry, biophysics, or a related field, with >6 years of relevant experience in a pharmaceutical drug discovery setting
Experience in structure-based drug design (e.g., docking and scoring, virtual screening, library design, homology modeling)
Experience with chemoinformatics and bioinformatics tools for database similarity searching, pharmacophore modeling, QSAR modeling, and identification and analysis of protein binding sites
Expert understanding of medicinal chemistry concepts and demonstrated success in addressing medicinal chemistry design challenges
A strong record of delivering portfolio success and driving projects through to the identification of high quality small-molecule drug candidates
Experience with in silico predictive methods for the improvement of physico-chemical and ADMET characteristics
Excellent awareness of current developments in computational chemistry and ability to identify opportunities to advance the science in this field
Experience with coaching and supporting junior computational and/or medicinal chemists
Strong programming/scripting capabilities (e.g., python, perl, OEChem toolkit, C++) desirable
Strong written and oral communication skills
Ability to work well in multi-disciplinary teams
Location
The position will be placed at AstraZeneca R&D Boston, USA
Visa Requirements
A valid visa for working in the US is required.
AstraZeneca offers a flexible environment and the kinds of benefits and rewards that boost morale, ease your mind, and allow you to concentrate on the things that matter most. It's no surprise to us that Astrazeneca wins awards for being a great place to work.
Working Mother Magazine's 100 Best Companies for Working Mothers, 2015 for the 14th consecutive year. Based on data gathered on the availability, usage and tracking of advancement programs, the representation of women, leave policies, benefits, child care, and more, AstraZeneca has been ranked as one of the top 100 best companies for working mothers again this year.
Top 50 Companies for Executive Women, NAFE, 2016 for the 8th consecutive year. The National Association for Female Executives (NAFE) recently named AstraZeneca as one of the top 50 companies for female executives for the sixth consecutive year.
Best Adoption-Friendly Workplaces in America, Dave Thomas Foundation for Adoption
Best Place to Work for LGBT Equality, Human Rights Campaign Foundation, 2015
Top 50 Companies for Diverse Managers, DiversityMBA Magazine
Visit astrazeneca.com for more information on the company's commitment to diversity and inclusion.
Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled/Sexual Orientation/Gender Identity
Requeriments :
Skills :
Areas :
Additional Info:
[Click Here to Access the Original Job Post]