Job ID: QMUL10626
Job date: 2017-02-11
End Date:
Company : Queen Mary University of London Country : Role : Postdoc
Job date: 2017-02-11
End Date:
Company : Queen Mary University of London Country : Role : Postdoc
Job Description:
We seek a Postdoctoral Researcher in Computational Biology to contribute to the delivery of high-quality research under the supervision of Dr. Damian Smedley. As a member of our team, you will contribute to the analysis and presentation of findings from the International Mouse Phenotyping Consortium (IMPC). The IMPC is a successful collaboration of some 20 institutes world-wide that aims to produce the first comprehensive, functional catalogue of a mammalian genome by systematic phenotyping of mouse knock-outs for every protein-coding gene in the mouse. The NIH-KOMP3 grant that funds the majority of this work was recently renewed for ~$100m over the next 5 years, including the informatics component (MPI2) consisting of teams at the European Bioinformatics Institute, MRC Harwell and QMUL. MPI2 is responsible for all data collection, QC, and analysis of the phenotypes as well as the presentation of the results on the IMPC portal. The post holder will be responsible with other members of the QMUL team for the maintenance and improvement of the human disease association pipeline as well as other research projects to investigate how the phenotypes relate to protein function, pathways, disease mechanisms and potential therapeutic interventions for patients containing disruptions of the same genes. There will be strong interactions with other members of the team that are funded through the Monarch Initiative to collaboratively develop the phenotype similarity algorithms that underlie much of our IMPC work as well as the Exomiser and Genomiser software suite of phenotype-aware variant prioritisation software being used in many large scale disease sequencing studies such as the 100,000 Genomes Project. Dr. Smedley holds a joint position as Director of Genomic Interpretation at Genomics England that is delivering the 100,000 Genomes Project and a major focus is on functional validation through IMPC resources of candidate variants from NHS patients enrolled in the project.
Additional Info:
The Centre is part of the world renowned William Harvey Research Institute (WHRI). In UK Research Assessment Exercise in 2008 65% of WHRI faculty were rated as world leading or internationally excellent and our Medical School was ranked amongst the top 5 in the UK (www.smd.qmul.ac.uk). We have recently joined University College London Partners Academic Health Sciences System which extends our reach to 5 million people and have recently joined the Russell Group of top research intensive UK Universities. The Centre offers newly refurbished laboratories, cutting edge facilities and is located in the heart of the City of London in close proximity to the Barbican Arts and Music Centre. The post is on fixed term contract until July 2021. Benefits include 30 days annual leave, defined benefit pension scheme, interest-free season ticket loan and family-friendly working. Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme. Informal enquiries about this post are welcome and can be made to Dr Damian Smedley (d.smedley@qmul.ac.uk). Details about the William Harvey Research Institute can be found on www.whri.qmul.ac.uk. Application enquiries should be directed to recruitment@qmul.ac.uk. Interviews will take place shortly after the closing date above. Valuing Diversity & Committed to Equality.[Click Here to Access the Original Job Post]
We seek a Postdoctoral Researcher in Computational Biology to contribute to the delivery of high-quality research under the supervision of Dr. Damian Smedley. As a member of our team, you will contribute to the analysis and presentation of findings from the International Mouse Phenotyping Consortium (IMPC). The IMPC is a successful collaboration of some 20 institutes world-wide that aims to produce the first comprehensive, functional catalogue of a mammalian genome by systematic phenotyping of mouse knock-outs for every protein-coding gene in the mouse. The NIH-KOMP3 grant that funds the majority of this work was recently renewed for ~$100m over the next 5 years, including the informatics component (MPI2) consisting of teams at the European Bioinformatics Institute, MRC Harwell and QMUL. MPI2 is responsible for all data collection, QC, and analysis of the phenotypes as well as the presentation of the results on the IMPC portal. The post holder will be responsible with other members of the QMUL team for the maintenance and improvement of the human disease association pipeline as well as other research projects to investigate how the phenotypes relate to protein function, pathways, disease mechanisms and potential therapeutic interventions for patients containing disruptions of the same genes. There will be strong interactions with other members of the team that are funded through the Monarch Initiative to collaboratively develop the phenotype similarity algorithms that underlie much of our IMPC work as well as the Exomiser and Genomiser software suite of phenotype-aware variant prioritisation software being used in many large scale disease sequencing studies such as the 100,000 Genomes Project. Dr. Smedley holds a joint position as Director of Genomic Interpretation at Genomics England that is delivering the 100,000 Genomes Project and a major focus is on functional validation through IMPC resources of candidate variants from NHS patients enrolled in the project.
Requeriments :
Areas :
Additional Info:
The Centre is part of the world renowned William Harvey Research Institute (WHRI). In UK Research Assessment Exercise in 2008 65% of WHRI faculty were rated as world leading or internationally excellent and our Medical School was ranked amongst the top 5 in the UK (www.smd.qmul.ac.uk). We have recently joined University College London Partners Academic Health Sciences System which extends our reach to 5 million people and have recently joined the Russell Group of top research intensive UK Universities. The Centre offers newly refurbished laboratories, cutting edge facilities and is located in the heart of the City of London in close proximity to the Barbican Arts and Music Centre. The post is on fixed term contract until July 2021. Benefits include 30 days annual leave, defined benefit pension scheme, interest-free season ticket loan and family-friendly working. Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme. Informal enquiries about this post are welcome and can be made to Dr Damian Smedley (d.smedley@qmul.ac.uk). Details about the William Harvey Research Institute can be found on www.whri.qmul.ac.uk. Application enquiries should be directed to recruitment@qmul.ac.uk. Interviews will take place shortly after the closing date above. Valuing Diversity & Committed to Equality.[Click Here to Access the Original Job Post]