Job ID: 246390142
Job date: 2016-12-08
End Date:
Company : Partners Healthcare Country : Role : Research Scientist
Job date: 2016-12-08
End Date:
Company : Partners Healthcare Country : Role : Research Scientist
Job Description:
Unique opportunity to join an interdisciplinary team bridging the Harvard Medical School, the Massachusetts General Hospital, and the Broad Institute of Harvard and MIT. The Lawrence Lab at the Massachusetts General Hospital Cancer Center seeks well-‐qualified candidates to join a team of computational biologists working at the forefront of cancer research and treatment. We use computation as a powerful microscope to study both the fundamental biology of cancer initiation and progression, as well the diagnosis and treatment of cancer patients in the hospital setting. Current Research Interests Of The Lawrence Lab: ‐ Cancer driver genes: tumors grow because of specific driver mutations that deactivate tumor suppressors or activate oncogenes. We are working to complete our understanding of the full catalog of cancer's "box of tricks". ‐ Resistance to targeted therapies: single drugs targeting specific driver mutations can be effective for a while, but the cancer invariably discovers a work-‐around. We are actively investigating mechanisms of drug resistance and how to combat it. ‐ Single-‐cell sequencing: New approaches allow us to dissect a tumor down to single cells and investigate the RNA expression or DNA mutations in each cell. Understanding intratumoral heterogeneity is shedding new light on cancer progression and patient outcomes. ‐ Liquid biopsies: novel state-‐of-‐the-‐art technologies are starting to allow us to monitor the progression of cancer(both before, during, and after treatment) through a simple blood draw. We are actively working to overcome analytical challenges inherent in the study of circulating tumor cells (CTCs) and cell-‐free circulating tumor DNA (ctDNA). ‐ Mutational processes: our genomes accumulate mutations from environmental agents such as ultraviolet radiation and tobacco smoke, as well as from intrinsic processes like errors during DNA replication. Studying these mutational background patterns can tell us what repair pathways are broken in a specific tumor, perhaps pointing the way to an effective genotoxic therapy. We are working to develop novel DNA sequencing technologies for studying mutagenesis in model systems. Primary Location: MA-Charlestown-13th Street - MGH Work Locations: 13th Street - MGH ‐Ph.D. in one of Computational Biology, Bioinformatics, Biology,Computer Science, Mathematics, Physics, or a related field. ‐ Independent, self-‐motivated drive to pushresearchforward. ‐ Strong publication record: first-‐author publication(s) in well-‐respected peer-‐ reviewed journals. ‐ Excellent programming skills (usingany of Matlab, R, Java,Python, Perl, C, etc.) ‐ Nimble approach to programming and data analysis, with an emphasis on simple, intuitive, reasoning: quickly open unfamiliar datasets, generate simple visualizations to project the data onto our brains as usefully as possible, to stimulate hypothesis generation and the next steps of the analysis. ‐ Comfort using Word, Excel, Powerpoint to communicate resultsbetween team members. ‐ Ability to work together with multi-‐disciplinary teams comprising physicians, biologists, statisticians, and software engineers. ‐ Fluency in spoken and written English ‐ Experience in "machine learning" welcomed Email: lawrence@broadinstitute.org
Additional Info:
Partners HealthCare is an integrated health care system, founded by Brigham and Women’s Hospital and Massachusetts General Hospital, that offers patients a continuum of coordinated and high-quality care. In addition to its two academic medical centers, the Partners system includes community and specialty hospitals, a managed care organization, a physician network, community health centers, home health and long-term care services, and other health care entities. Partners HealthCare is committed to patient care, research, teaching, and service to the community. Partners is one of the nation’s leading biomedical research organizations and several Partners hospitals are principal teaching affiliates of Harvard Medical School. Partners HealthCare is a non-profit organization.[Click Here to Access the Original Job Post]
Unique opportunity to join an interdisciplinary team bridging the Harvard Medical School, the Massachusetts General Hospital, and the Broad Institute of Harvard and MIT. The Lawrence Lab at the Massachusetts General Hospital Cancer Center seeks well-‐qualified candidates to join a team of computational biologists working at the forefront of cancer research and treatment. We use computation as a powerful microscope to study both the fundamental biology of cancer initiation and progression, as well the diagnosis and treatment of cancer patients in the hospital setting. Current Research Interests Of The Lawrence Lab: ‐ Cancer driver genes: tumors grow because of specific driver mutations that deactivate tumor suppressors or activate oncogenes. We are working to complete our understanding of the full catalog of cancer's "box of tricks". ‐ Resistance to targeted therapies: single drugs targeting specific driver mutations can be effective for a while, but the cancer invariably discovers a work-‐around. We are actively investigating mechanisms of drug resistance and how to combat it. ‐ Single-‐cell sequencing: New approaches allow us to dissect a tumor down to single cells and investigate the RNA expression or DNA mutations in each cell. Understanding intratumoral heterogeneity is shedding new light on cancer progression and patient outcomes. ‐ Liquid biopsies: novel state-‐of-‐the-‐art technologies are starting to allow us to monitor the progression of cancer(both before, during, and after treatment) through a simple blood draw. We are actively working to overcome analytical challenges inherent in the study of circulating tumor cells (CTCs) and cell-‐free circulating tumor DNA (ctDNA). ‐ Mutational processes: our genomes accumulate mutations from environmental agents such as ultraviolet radiation and tobacco smoke, as well as from intrinsic processes like errors during DNA replication. Studying these mutational background patterns can tell us what repair pathways are broken in a specific tumor, perhaps pointing the way to an effective genotoxic therapy. We are working to develop novel DNA sequencing technologies for studying mutagenesis in model systems. Primary Location: MA-Charlestown-13th Street - MGH Work Locations: 13th Street - MGH ‐Ph.D. in one of Computational Biology, Bioinformatics, Biology,Computer Science, Mathematics, Physics, or a related field. ‐ Independent, self-‐motivated drive to pushresearchforward. ‐ Strong publication record: first-‐author publication(s) in well-‐respected peer-‐ reviewed journals. ‐ Excellent programming skills (usingany of Matlab, R, Java,Python, Perl, C, etc.) ‐ Nimble approach to programming and data analysis, with an emphasis on simple, intuitive, reasoning: quickly open unfamiliar datasets, generate simple visualizations to project the data onto our brains as usefully as possible, to stimulate hypothesis generation and the next steps of the analysis. ‐ Comfort using Word, Excel, Powerpoint to communicate resultsbetween team members. ‐ Ability to work together with multi-‐disciplinary teams comprising physicians, biologists, statisticians, and software engineers. ‐ Fluency in spoken and written English ‐ Experience in "machine learning" welcomed Email: lawrence@broadinstitute.org
Requeriments :
Skills :
- Cancer biology
- Computational Biology
- Database design
- Machine Learning
- Programing in C
- Programing in Python
- Programing Skills
- Programming in Java
- Programming in Matlab
- Programming in PERL
- Programming in R
Areas :
Additional Info:
Partners HealthCare is an integrated health care system, founded by Brigham and Women’s Hospital and Massachusetts General Hospital, that offers patients a continuum of coordinated and high-quality care. In addition to its two academic medical centers, the Partners system includes community and specialty hospitals, a managed care organization, a physician network, community health centers, home health and long-term care services, and other health care entities. Partners HealthCare is committed to patient care, research, teaching, and service to the community. Partners is one of the nation’s leading biomedical research organizations and several Partners hospitals are principal teaching affiliates of Harvard Medical School. Partners HealthCare is a non-profit organization.[Click Here to Access the Original Job Post]